| Altered hub configurations during propofol-induced loss of consciousness | |
Li, Huandong1 ; Liu, Xiaoyuan2; Jie, Nanfeng1; Jiang, Tianzi1
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| 2016 | |
| 会议名称 | IET International Conference on Biomedical Image and Signal Processing (ICBISP) |
| 会议录名称 | ICBISP conference proceedings |
| 会议日期 | 2015-11-19 |
| 会议地点 | 北京 |
| 会议主办者 | The Institution of Engineering and Technology (IET) |
| 摘要 | Graph-theoretical analysis of human brain functional networks based on functional magnetic resonance imaging (fMRI) have supported the existence of highly connected hub regions that may play a key role in brain function and cognition. Here, we investigated the hub distributions of 16 healthy volunteers during wakefulness and propofol-induced loss of consciousness (both light sedation and deep sedation). Functional connectivity between 160 cortical and subcortical regions was measured by correlation analysis and then thresholded to construct undirected graphs. We found that during wakefulness state highly connected hubs included bilateral angular, precuneus, posterior cingulate (PCC), superior frontal gyrus (SFG), ventrolateral frontal cortex (vFC), supplementary motor area (SMA) and pre-SMA, most of the which were in the default-mode network (DMN). However, during light sedation, we observed that hubs were mainly in posterior part of the brain (inferior parietal lobule, inferior temporal, occipital). And the major hubs during deep sedation were in the occipital lobe and cerebellum. Compared with wakefulness, the hub structures were significantly changed from heteromodal association cortex to unimodal association and primary cortices. Our findings support a reduction in integrated information and a topological reconfiguration during decreasing levels of consciousness. |
| 其他摘要 | 无 |
| 关键词 | Propofol Functional Mri Hub Graph Theory Consciousness |
| URL | 查看原文 |
| 收录类别 | EI |
| 语种 | 英语 |
| 文献类型 | 会议论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/10556 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 通讯作者 | Li, Huandong |
| 作者单位 | 1.Brainnetome Center, Institute of Automation, Chinese Academy of Sciences 2.Capital University of Medical Sciences Affiliated Tiantan Hospital |
| 第一作者单位 | 中国科学院自动化研究所 |
| 通讯作者单位 | 中国科学院自动化研究所 |
| 推荐引用方式 GB/T 7714 | Li, Huandong,Liu, Xiaoyuan,Jie, Nanfeng,et al. Altered hub configurations during propofol-induced loss of consciousness[C],2016. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| ICBISP15_0074_final.（213KB） | 会议论文 | 开放获取 | CC BY-NC-SA | 浏览 下载 | ||
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