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Altered hub configurations during propofol-induced loss of consciousness
Li, Huandong1; Liu, Xiaoyuan2; Jie, Nanfeng1; Jiang, Tianzi1
2016
会议名称IET International Conference on Biomedical Image and Signal Processing (ICBISP)
会议录名称ICBISP conference proceedings
会议日期2015-11-19
会议地点北京
会议主办者The Institution of Engineering and Technology (IET)
摘要Graph-theoretical analysis of human brain functional networks based on functional magnetic resonance imaging (fMRI) have supported the existence of highly connected hub regions that may play a key role in brain function and cognition. Here, we investigated the hub distributions of 16 healthy volunteers during wakefulness and propofol-induced loss of consciousness (both light sedation and deep sedation). Functional connectivity between 160 cortical and subcortical regions was measured by correlation analysis and then thresholded to construct undirected graphs. We found that during wakefulness state  highly connected hubs included bilateral angular, precuneus, posterior cingulate (PCC), superior frontal gyrus (SFG), ventrolateral frontal cortex (vFC), supplementary motor area (SMA) and pre-SMA,  most of the which were  in the default-mode network (DMN). However, during light sedation, we observed that hubs were mainly in posterior part of the brain (inferior parietal lobule, inferior temporal, occipital). And the major hubs during deep sedation were in the occipital lobe and cerebellum. Compared with wakefulness, the hub structures were significantly changed from heteromodal association cortex to unimodal association and primary cortices. Our findings support a reduction in integrated information and a topological reconfiguration during decreasing levels of consciousness.
其他摘要
关键词Propofol Functional Mri Hub Graph Theory Consciousness
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收录类别EI
语种英语
文献类型会议论文
条目标识符http://ir.ia.ac.cn/handle/173211/10556
专题脑网络组研究中心
通讯作者Li, Huandong
作者单位1.Brainnetome Center, Institute of Automation, Chinese Academy of Sciences
2.Capital University of Medical Sciences Affiliated Tiantan Hospital
推荐引用方式
GB/T 7714
Li, Huandong,Liu, Xiaoyuan,Jie, Nanfeng,et al. Altered hub configurations during propofol-induced loss of consciousness[C],2016.
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