CASIA OpenIR  > 中国科学院分子影像重点实验室
Aberrant Topological Patterns of Structural Cortical Networks in Psychogenic Erectile Dysfunction
Zhao, Lu1; Guan, Min2; Zhu, Xiaobo3; Karama, Sherif1,4; Khundrakpam, Budhachandra1; Wang, Meiyun2; Dong, Minghao5; Qin, Wei5; Tian, Jie5,6; Evans, Alan C.1; Shi, Dapeng2
Source PublicationFRONTIERS IN HUMAN NEUROSCIENCE
2015-12-18
Volume9Issue:157Pages:180-180
SubtypeArticle
AbstractMale sexual arousal (SA) has been known as a multidimensional experience involving closely interrelated and coordinated neurobehavioral components that rely on widespread brain regions. Recent functional neuroimaging studies have shown relation between abnormal/altered dynamics in these circuits and male sexual dysfunction. However, alterations in the topological(1) organization of structural brain networks in male sexual dysfunction are still unclear. Here, we used graph theory(2) to investigate the topological properties of large-scale structural brain networks, which were constructed using inter-regional correlations of cortical thickness between 78 cortical regions in 40 patients with psychogenic erectile dysfunction (pED) and 39 normal controls. Compared with normal controls, pED patients exhibited a less optimal global topological organization with reduced global and increased local efficiencies. Our results suggest disrupted neural integration among distant brain regions in pED patients, consistent with previous reports of impaired white matter structure and abnormal functional integrity in pED. Additionally, disrupted global network topology in pED was observed to be primarily relevant to altered subnetwork and nodal properties within the networks mediating the cognitive, motivational and inhibitory processes of male SA, possibly indicating disrupted integration of these networks in the whole brain networks and might account for pED patients' abnormal cognitive, motivational and inhibitory processes for male SA. In total, our findings provide evidence for disrupted integrity in large-scale brain networks underlying the neurobehavioral processes of male SA in pED and provide new insights into the understanding of the pathophysiological mechanisms of pED.
KeywordMale Sexual Arousal Magnetic Resonance Imaging Network Topology Graph Theory Psychogenic Erectile Dysfunction
WOS HeadingsScience & Technology ; Social Sciences ; Life Sciences & Biomedicine
DOI10.3389/fnhum.2015.00675
WOS KeywordVISUAL SEXUAL STIMULI ; ANTERIOR CINGULATE CORTEX ; HUMAN CEREBRAL-CORTEX ; SMALL-WORLD NETWORKS ; BRAIN ACTIVATION ; QUANTITATIVE METAANALYSIS ; INTERNATIONAL INDEX ; FUNCTION IIEF ; HEALTHY-MEN ; HUMAN MALES
Indexed BySCI
Language英语
Funding OrganizationCanadian Institutes of Health Research(CIHR-MOP 37754) ; Chinese Nature Science Foundation(81271534)
WOS Research AreaNeurosciences & Neurology ; Psychology
WOS SubjectNeurosciences ; Psychology
WOS IDWOS:000367050400001
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10647
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada
2.Henan Prov Peoples Hosp, Dept Radiol, Zhengzhou, Peoples R China
3.Henan Prov Peoples Hosp, Dept Urol, Zhengzhou, Peoples R China
4.McGill Univ, Douglas Mental Hlth Univ, Montreal, PQ, Canada
5.Xidian Univ, Sch Life Sci & Technol, Xian, Peoples R China
6.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Lu,Guan, Min,Zhu, Xiaobo,et al. Aberrant Topological Patterns of Structural Cortical Networks in Psychogenic Erectile Dysfunction[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2015,9(157):180-180.
APA Zhao, Lu.,Guan, Min.,Zhu, Xiaobo.,Karama, Sherif.,Khundrakpam, Budhachandra.,...&Shi, Dapeng.(2015).Aberrant Topological Patterns of Structural Cortical Networks in Psychogenic Erectile Dysfunction.FRONTIERS IN HUMAN NEUROSCIENCE,9(157),180-180.
MLA Zhao, Lu,et al."Aberrant Topological Patterns of Structural Cortical Networks in Psychogenic Erectile Dysfunction".FRONTIERS IN HUMAN NEUROSCIENCE 9.157(2015):180-180.
Files in This Item: Download All
File Name/Size DocType Version Access License
fnhum-09-00675.pdf(4489KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhao, Lu]'s Articles
[Guan, Min]'s Articles
[Zhu, Xiaobo]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhao, Lu]'s Articles
[Guan, Min]'s Articles
[Zhu, Xiaobo]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhao, Lu]'s Articles
[Guan, Min]'s Articles
[Zhu, Xiaobo]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: fnhum-09-00675.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.