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Remarkable NIR Enhancement of Multifunctional Nanoprobes for In Vivo Trimodal Bioimaging and Upconversion Optical/T-2-Weighted MRI-Guided Small Tumor Diagnosis
Yi, Zhigao1,2,3; Li, Xiaolong1,2; Xue, Zhenluan1,2; Liang, Xiao4; Lu, Wei5,6; Peng, Hao7; Liu, Hongrong1,2; Zeng, Songjun1,2; Hao, Jianhua5,6
Source PublicationADVANCED FUNCTIONAL MATERIALS
2015-12-09
Volume25Issue:46Pages:7119-7129
SubtypeArticle
AbstractEffective nanoprobes and contrast agents are urgently sought for early-stage cancer diagnosis. Upconversion nanoparticles (UCNPs) are considerable alternatives for bioimaging, cancer diagnosis, and therapy. Yb3+/ Tm3+ co-doping brings both emission and excitation wavelengths into the near-infrared (NIR) region, which is known as "optical transmission window" and ideally suitable for bioimaging. Here, NIR emission intensity is remarkably enhanced by 113 times with the increase of Yb3+ concentration from 20% to 98% in polyethylene glycol ( PEG) modified NaYF4:Yb3+/ Tm3+ UCNPs. PEG-UCNPs-5 (98% Yb3+) can act as excellent nanoprobes and contrast agents for trimodal upconversion (UC) optical/CT/T-2-weighted magnetic resonance imaging (MRI). In addition, the enhanced detection of lung in vivo long-lasting tracking, as well as possible clearance mechanism and excretion routes of PEG-UCNPs-5 have been demonstrated. More significantly, a small tumor down to 4 mm is detected in vivo via intravenous injection of these nanoprobes under both UC optical and T-2-weighted MRI modalities. PEG-UCNPs-5 can emerge as bioprobes for multi-modal bioimaging, disease diagnosis, and therapy, especially the early-stage tumor diagnosis.
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1002/adfm.201503672
WOS KeywordCOMPUTED-TOMOGRAPHY ; CONTRAST-MEDIA ; NANO-BIOPROBES ; DRUG-DELIVERY ; NANOCRYSTALS ; NANOPARTICLES ; NANOMATERIALS ; LUMINESCENCE ; THERAPY ; PHASE
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(51102202 ; Specialized Research Fund for the Doctoral Program of Higher Education of China(20114301120006) ; Hunan Provincial Natural Science Foundation of China(12JJ4056) ; Scientific Research Fund of Hunan Provincial Education Department(13B062) ; CAS/SAFEA ; 31370736)
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000366503700002
Citation statistics
Cited Times:66[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10728
Collection中国科学院分子影像重点实验室
Affiliation1.Hunan Normal Univ, Coll Phys & Informat Sci, Changsha 410081, Hunan, Peoples R China
2.Hunan Normal Univ, Key Lab Low Dimens Quantum Struct & Quantum Contr, Minist Educ, Changsha 410081, Hunan, Peoples R China
3.Xiangtan Univ, Sch Mat Sci & Engn, Key Lab Low Dimens Mat & Applicat Technol, Minist Educ, Xiangtan 411105, Peoples R China
4.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
5.Hong Kong Polytech Univ, Dept Appl Phys, Hong Kong, Hong Kong, Peoples R China
6.Hong Kong Polytech Univ, Mat Res Ctr, Hong Kong, Hong Kong, Peoples R China
7.Hunan Normal Univ, Sch Life Sci, Res Ctr Heart Dev, Changsha 410081, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Yi, Zhigao,Li, Xiaolong,Xue, Zhenluan,et al. Remarkable NIR Enhancement of Multifunctional Nanoprobes for In Vivo Trimodal Bioimaging and Upconversion Optical/T-2-Weighted MRI-Guided Small Tumor Diagnosis[J]. ADVANCED FUNCTIONAL MATERIALS,2015,25(46):7119-7129.
APA Yi, Zhigao.,Li, Xiaolong.,Xue, Zhenluan.,Liang, Xiao.,Lu, Wei.,...&Hao, Jianhua.(2015).Remarkable NIR Enhancement of Multifunctional Nanoprobes for In Vivo Trimodal Bioimaging and Upconversion Optical/T-2-Weighted MRI-Guided Small Tumor Diagnosis.ADVANCED FUNCTIONAL MATERIALS,25(46),7119-7129.
MLA Yi, Zhigao,et al."Remarkable NIR Enhancement of Multifunctional Nanoprobes for In Vivo Trimodal Bioimaging and Upconversion Optical/T-2-Weighted MRI-Guided Small Tumor Diagnosis".ADVANCED FUNCTIONAL MATERIALS 25.46(2015):7119-7129.
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