Remarkable NIR Enhancement of Multifunctional Nanoprobes for In Vivo Trimodal Bioimaging and Upconversion Optical/T-2-Weighted MRI-Guided Small Tumor Diagnosis

doi:10.1002/adfm.201503672

	Remarkable NIR Enhancement of Multifunctional Nanoprobes for In Vivo Trimodal Bioimaging and Upconversion Optical/T-2-Weighted MRI-Guided Small Tumor Diagnosis
	Yi, Zhigao 1,2,3; Li, Xiaolong 1,2; Xue, Zhenluan 1,2; Liang, Xiao4 ; Lu, Wei 5,6; Peng, Hao 7; Liu, Hongrong 1,2; Zeng, Songjun 1,2; Hao, Jianhua 5,6
发表期刊	ADVANCED FUNCTIONAL MATERIALS
	2015-12-09
卷号	25 期号:46 页码:7119-7129
文章类型	Article
摘要	Effective nanoprobes and contrast agents are urgently sought for early-stage cancer diagnosis. Upconversion nanoparticles (UCNPs) are considerable alternatives for bioimaging, cancer diagnosis, and therapy. Yb3+/ Tm3+ co-doping brings both emission and excitation wavelengths into the near-infrared (NIR) region, which is known as "optical transmission window" and ideally suitable for bioimaging. Here, NIR emission intensity is remarkably enhanced by 113 times with the increase of Yb3+ concentration from 20% to 98% in polyethylene glycol ( PEG) modified NaYF4:Yb3+/ Tm3+ UCNPs. PEG-UCNPs-5 (98% Yb3+) can act as excellent nanoprobes and contrast agents for trimodal upconversion (UC) optical/CT/T-2-weighted magnetic resonance imaging (MRI). In addition, the enhanced detection of lung in vivo long-lasting tracking, as well as possible clearance mechanism and excretion routes of PEG-UCNPs-5 have been demonstrated. More significantly, a small tumor down to 4 mm is detected in vivo via intravenous injection of these nanoprobes under both UC optical and T-2-weighted MRI modalities. PEG-UCNPs-5 can emerge as bioprobes for multi-modal bioimaging, disease diagnosis, and therapy, especially the early-stage tumor diagnosis.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
DOI	10.1002/adfm.201503672
关键词[WOS]	COMPUTED-TOMOGRAPHY ; CONTRAST-MEDIA ; NANO-BIOPROBES ; DRUG-DELIVERY ; NANOCRYSTALS ; NANOPARTICLES ; NANOMATERIALS ; LUMINESCENCE ; THERAPY ; PHASE
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(51102202 ; Specialized Research Fund for the Doctoral Program of Higher Education of China(20114301120006) ; Hunan Provincial Natural Science Foundation of China(12JJ4056) ; Scientific Research Fund of Hunan Provincial Education Department(13B062) ; CAS/SAFEA ; 31370736)
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000366503700002
引用统计	被引频次：113[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/10728
专题	中国科学院分子影像重点实验室
作者单位	1.Hunan Normal Univ, Coll Phys & Informat Sci, Changsha 410081, Hunan, Peoples R China 2.Hunan Normal Univ, Key Lab Low Dimens Quantum Struct & Quantum Contr, Minist Educ, Changsha 410081, Hunan, Peoples R China 3.Xiangtan Univ, Sch Mat Sci & Engn, Key Lab Low Dimens Mat & Applicat Technol, Minist Educ, Xiangtan 411105, Peoples R China 4.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 5.Hong Kong Polytech Univ, Dept Appl Phys, Hong Kong, Hong Kong, Peoples R China 6.Hong Kong Polytech Univ, Mat Res Ctr, Hong Kong, Hong Kong, Peoples R China 7.Hunan Normal Univ, Sch Life Sci, Res Ctr Heart Dev, Changsha 410081, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Yi, Zhigao,Li, Xiaolong,Xue, Zhenluan,et al. Remarkable NIR Enhancement of Multifunctional Nanoprobes for In Vivo Trimodal Bioimaging and Upconversion Optical/T-2-Weighted MRI-Guided Small Tumor Diagnosis[J]. ADVANCED FUNCTIONAL MATERIALS,2015,25(46):7119-7129.
APA	Yi, Zhigao.,Li, Xiaolong.,Xue, Zhenluan.,Liang, Xiao.,Lu, Wei.,...&Hao, Jianhua.(2015).Remarkable NIR Enhancement of Multifunctional Nanoprobes for In Vivo Trimodal Bioimaging and Upconversion Optical/T-2-Weighted MRI-Guided Small Tumor Diagnosis.ADVANCED FUNCTIONAL MATERIALS,25(46),7119-7129.
MLA	Yi, Zhigao,et al."Remarkable NIR Enhancement of Multifunctional Nanoprobes for In Vivo Trimodal Bioimaging and Upconversion Optical/T-2-Weighted MRI-Guided Small Tumor Diagnosis".ADVANCED FUNCTIONAL MATERIALS 25.46(2015):7119-7129.