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Interaction of COMT rs4680 and BDNF rs6265 Polymorphisms on Functional Connectivity Density of the Left Frontal Eye Field in Healthy Young Adults | |
Li, Wei1,2; Liu, Bing3![]() ![]() | |
发表期刊 | HUMAN BRAIN MAPPING
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2016-07-01 | |
卷号 | 37期号:7页码:2468-2478 |
文章类型 | Article |
摘要 | As modulators of dopamine availability and release in the brain, COMT and BDNF polymorphisms have demonstrated interactions on human cognition; however, the underlying neural mechanisms remain largely unknown. In this study, we aimed to investigate the interactions of COMT rs4680 and BDNF rs6265 on global functional connectivity density (gFCD) of the brain in 265 healthy young subjects. We found a significant COMT x BDNF interaction on the gFCD in the left frontal eye field (FEF), showing an inverted U-shape modulation by the presumed dopamine signaling. This finding was consistently repeated in the gFCD analyses using other four connection thresholds. Our findings reveal a COMT x BDNF interaction on the FCD in the left FEF, which may be helpful for understanding the neural mechanisms of the COMT x BDNF interactions on the FEF-related cognitive functions. (C) 2016 Wiley Periodicals, Inc. |
关键词 | Comt Bdnf Functional Connectivity Density Dopamine Attention |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1002/hbm.23187 |
关键词[WOS] | CATECHOL-O-METHYLTRANSFERASE ; DEFICIT HYPERACTIVITY DISORDER ; ACTIVITY-DEPENDENT SECRETION ; NEUROTROPHIC-FACTOR ; VAL66MET POLYMORPHISM ; HUMAN BRAIN ; TOP-DOWN ; DRD2 POLYMORPHISMS ; COGNITIVE-ABILITY ; GENE POLYMORPHISM |
收录类别 | SCI ; SSCI |
语种 | 英语 |
项目资助者 | National Natural Science Foundation of China(81425013 ; 91332113 ; 81271551 ; 81301201 ; 81301202) |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000382488800009 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/10822 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
作者单位 | 1.Tianjin Med Univ, Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China 2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Wei,Liu, Bing,Xu, Jiayuan,et al. Interaction of COMT rs4680 and BDNF rs6265 Polymorphisms on Functional Connectivity Density of the Left Frontal Eye Field in Healthy Young Adults[J]. HUMAN BRAIN MAPPING,2016,37(7):2468-2478. |
APA | Li, Wei,Liu, Bing,Xu, Jiayuan,Jiang, Tianzi,&Yu, Chunshui.(2016).Interaction of COMT rs4680 and BDNF rs6265 Polymorphisms on Functional Connectivity Density of the Left Frontal Eye Field in Healthy Young Adults.HUMAN BRAIN MAPPING,37(7),2468-2478. |
MLA | Li, Wei,et al."Interaction of COMT rs4680 and BDNF rs6265 Polymorphisms on Functional Connectivity Density of the Left Frontal Eye Field in Healthy Young Adults".HUMAN BRAIN MAPPING 37.7(2016):2468-2478. |
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