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Penetrating Peptide-Bioconjugated Persistent Nanophosphors for Long-Term Tracking of Adipose-Derived Stem Cells with Superior Signal-to-Noise Ratio
Wu, Shu-Qi1; Chi, Chong-Wei3; Yang, Cheng-Xiong1; Yan, Xiu-Ping1,2
2016-04-05
发表期刊ANALYTICAL CHEMISTRY
卷号88期号:7页码:4114-4121
文章类型Article
摘要Reliable long-term in vivo tracking of stem cells is of great importance in stem cell-based therapy and research. Fluorescence imaging with in situ excitation has significant autofluorescence background, which results in poor signal-to-noise ratio (SNR). Here we report TAT penetrating peptide-bioconjugated long persistent luminescence nanoparticles (LPLNP-TAT) for long-term tracking of adipose-derived stem cells (ASC) without constant external excitation. LPLNP-TAT exhibits near-infrared emitting, red light renewable capability, and superior in vivo imaging depth and SNR compared with conventional organic dye and quantum dots. Our findings show that LPLNP-TAT can successfully label ASC without impairing their proliferation and differentiation and can effectively track ASC in skin-regeneration and tumor-homing models. We believe that LPLNP-TAT represents a new generation of cell tracking probes and will have broad application in diagnosis and therapy.
WOS标题词Science & Technology ; Physical Sciences
DOI10.1021/acs.analchem.6b00449
关键词[WOS]UP-CONVERSION NANOPARTICLES ; REGENERATIVE MEDICINE ; LUMINESCENT NANOPROBES ; THERAPY ; ENGRAFTMENT ; NANODOTS ; DELIVERY ; LIFETIME
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(21435001 ; National Basic Research Program of China(2011CB707703) ; 21275079 ; 81227901 ; 61501462)
WOS研究方向Chemistry
WOS类目Chemistry, Analytical
WOS记录号WOS:000373656300092
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/11318
专题中国科学院分子影像重点实验室
作者单位1.Nankai Univ, State Key Lab Med Chem Biol, Res Ctr Analyt Sci, Coll Chem, Tianjin 300071, Peoples R China
2.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
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Wu, Shu-Qi,Chi, Chong-Wei,Yang, Cheng-Xiong,et al. Penetrating Peptide-Bioconjugated Persistent Nanophosphors for Long-Term Tracking of Adipose-Derived Stem Cells with Superior Signal-to-Noise Ratio[J]. ANALYTICAL CHEMISTRY,2016,88(7):4114-4121.
APA Wu, Shu-Qi,Chi, Chong-Wei,Yang, Cheng-Xiong,&Yan, Xiu-Ping.(2016).Penetrating Peptide-Bioconjugated Persistent Nanophosphors for Long-Term Tracking of Adipose-Derived Stem Cells with Superior Signal-to-Noise Ratio.ANALYTICAL CHEMISTRY,88(7),4114-4121.
MLA Wu, Shu-Qi,et al."Penetrating Peptide-Bioconjugated Persistent Nanophosphors for Long-Term Tracking of Adipose-Derived Stem Cells with Superior Signal-to-Noise Ratio".ANALYTICAL CHEMISTRY 88.7(2016):4114-4121.
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