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Potential drug targets prediction for H1N1 influenza A based on protein-protein interaction networks
Chen,Di1; Liu,Xi1; Chen,Chang2; Chen,Lin1; Gao,Yibo1; Yi,Jianqiang1; Tang,Shihuan2; Lu,Peng1; Yang,Hongjun2; Lu, Peng; Yang, Hongjun
2012-11
发表期刊African Journal of Pharmacy and Pharmacology
卷号6期号:42页码:2950-2955
摘要
In  this  paper,  some  proteins  were  determined  as  potential  drug  targets  for  H1N1  influenza  A.  These proteins were found using  three steps: i)  determining a set of human proteins that  had interactions with the  proteins  of  H1N1  virus,  and  assigning  a  weight  to  each  protein;  ii)  mapping  the  set  of  human proteins into the human protein-protein interaction networks; iii) combining  the topological properties of the network and the weights of the proteins to determine the score of each node.  Eventually , TRAF2 
and  MAPK9,  two  nodes  with  high  scores,  were  regarded  as  potential  drug  targets.  The  results  were consistent  when  different  databases  were  used,  and  were  in  agreement  with  the  KEGG  pathways  to some degree. However, it still needs further study  to ascertain  whether these potential targets can be novel practical targets applied in the drug design.
关键词Protein-protein Interactions Network Drug Targets H1n1 Influenza a
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/11446
专题综合信息系统研究中心
通讯作者Lu, Peng; Yang, Hongjun
作者单位1.Institute of Automation, Chinese Academy of Sciences
2.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences
推荐引用方式
GB/T 7714
Chen,Di,Liu,Xi,Chen,Chang,et al. Potential drug targets prediction for H1N1 influenza A based on protein-protein interaction networks[J]. African Journal of Pharmacy and Pharmacology,2012,6(42):2950-2955.
APA Chen,Di.,Liu,Xi.,Chen,Chang.,Chen,Lin.,Gao,Yibo.,...&Yang, Hongjun.(2012).Potential drug targets prediction for H1N1 influenza A based on protein-protein interaction networks.African Journal of Pharmacy and Pharmacology,6(42),2950-2955.
MLA Chen,Di,et al."Potential drug targets prediction for H1N1 influenza A based on protein-protein interaction networks".African Journal of Pharmacy and Pharmacology 6.42(2012):2950-2955.
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