A Novel Endoscopic Cerenkov Luminescence Imaging System for Intraoperative Surgical Navigation

	A Novel Endoscopic Cerenkov Luminescence Imaging System for Intraoperative Surgical Navigation
	Tianming Song; Xia Liu; Yawei Qu; Haixiao Liu; Chengpeng Bao; Chengcai Leng; Zhenhua Hu; Kun Wang; Jie Tian
发表期刊	Molecular Imaging
	2015-08
卷号	14 期号:8 页码:7290
摘要	Cerenkov luminescence imaging is an emerging optical technique for imaging the distribution of radiopharmaceuticals in vivo. However, because of the light scattering effect, it cannot obtain optical information from deep internal organs. To overcome this challenge, we established a novel endoscopic Cerenkov luminescence imaging system that used a clinically approved laparoscope and an electronmultiplying charge-coupled device camera. We assessed the performance of the system through a series of in vitro and in vivo experiments. The results demonstrated superior superficial imaging resolution (0.1 mm), a large field of view (500 mm2 with 10 mm imaging distance), and superb imaging sensitivity (imaging 1 μCi) of our system. It captured the weak Cerenkov signal from internal organs successfully and was applied to intraoperative surgical navigation of tumor resection. It offered objective information of the tumor location and tumor residual during the surgical operation. This technique holds great potential for clinical translation.
关键词	Endoscopic Cerenkov Luminescence Imaging System
WOS记录号	WOS:000365597500002
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/11997
专题	中国科学院分子影像重点实验室
通讯作者	Zhenhua Hu
推荐引用方式 GB/T 7714	Tianming Song,Xia Liu,Yawei Qu,et al. A Novel Endoscopic Cerenkov Luminescence Imaging System for Intraoperative Surgical Navigation[J]. Molecular Imaging,2015,14(8):7290.
APA	Tianming Song.,Xia Liu.,Yawei Qu.,Haixiao Liu.,Chengpeng Bao.,...&Jie Tian.(2015).A Novel Endoscopic Cerenkov Luminescence Imaging System for Intraoperative Surgical Navigation.Molecular Imaging,14(8),7290.
MLA	Tianming Song,et al."A Novel Endoscopic Cerenkov Luminescence Imaging System for Intraoperative Surgical Navigation".Molecular Imaging 14.8(2015):7290.

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