Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study | |
Li, Xuan-yu1; Tang, Zhen-chao3; Sun, Yu1; Tian, Jie2; Liu, Zhen-yu2; Han, Ying1,4; Zhenyu Liu | |
发表期刊 | ONCOTARGET |
2016-08-23 | |
卷号 | 7期号:34页码:54405-54414 |
文章类型 | Article |
摘要 | ; Subjective cognitive decline (SCD) may be an at-risk stage of Alzheimer's disease (AD) occurring prior to amnestic mild cognitive impairment (aMCI). To examine white matter (WM) defects in SCD, diffusion images from 27 SCD (age=65.3+/-8.0), 35 aMCI (age=69.2+/-8.6) and 25 AD patients (age=68.3+/-9.4) and 37 normal controls (NC) (age=65.1+/-6.8) were compared using Tract-Based Spatial Statistics (TBSS). WM impairments common to the three patient groups were extracted, and fractional anisotropy (FA) values were averaged in each group. As compared to NC subjects, SCD patients displayed widespread WM alterations represented by decreased FA (p<0.05), increased mean diffusivity (MD; p<0.05), and increased radial diffusivity (RD; p<0.05). In addition, localized WM alterations showed increased axial diffusivity (AxD; p<0.05) similar to what was observed in aMCI and AD patients (p<0.05). In the shared WM impairment tracts, SCD patients had FA values between the NC group and the other two patient groups. In the NC and SCD groups, the AVLT-delayed recall score correlated with higher AxD (r=-0.333, p=0.045), MD (r=-0.351, p=0.03) and RD (r=-0.353, p=0.025). In both the aMCI and AD groups the diffusion parameters were highly correlated with cognitive scores. Our study suggests that SCD patients present with widespread WM changes, which may contribute to the early memory decline they experience. |
关键词 | Subjective Cognitive Decline Diffusion Tensor Imaging Preclinical Alzheimer's Disease White Matter Tract-based Spatial Statistics |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.18632/oncotarget.10091 |
关键词[WOS] | ALZHEIMERS-DISEASE ; MEMORY IMPAIRMENT ; CEREBROSPINAL-FLUID ; WATER DIFFUSION ; FUNCTIONAL MRI ; BRAIN ; COMPLAINTS ; ATROPHY ; MCI ; DYSMYELINATION |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | National Natural Science Foundation of China(31371007 ; Beijing Municipal Science & Technology Commission(Z131100006813022) ; Kallikrein Medical Research Program(201206006) ; National Key Department of Neurology - Chinese Health and Family Planning Committee ; 81430037 ; 30970823 ; 81501549) |
WOS研究方向 | Oncology ; Cell Biology |
WOS类目 | Oncology ; Cell Biology |
WOS记录号 | WOS:000385435000026 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/12108 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Zhenyu Liu |
作者单位 | 1.Capital Med Univ, XuanWu Hosp, Dept Neurol, Beijing 100053, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Shandong Univ, Sch Mech Elect & Informat Engn, Weihai 264209, Shandong, Peoples R China 4.Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing 100053, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Xuan-yu,Tang, Zhen-chao,Sun, Yu,et al. White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study[J]. ONCOTARGET,2016,7(34):54405-54414. |
APA | Li, Xuan-yu.,Tang, Zhen-chao.,Sun, Yu.,Tian, Jie.,Liu, Zhen-yu.,...&Zhenyu Liu.(2016).White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study.ONCOTARGET,7(34),54405-54414. |
MLA | Li, Xuan-yu,et al."White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study".ONCOTARGET 7.34(2016):54405-54414. |
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