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White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study
Li, Xuan-yu1; Tang, Zhen-chao3; Sun, Yu1; Tian, Jie2; Liu, Zhen-yu2; Han, Ying1,4; Zhenyu Liu
Source PublicationONCOTARGET
; Subjective cognitive decline (SCD) may be an at-risk stage of Alzheimer's disease (AD) occurring prior to amnestic mild cognitive impairment (aMCI). To examine white matter (WM) defects in SCD, diffusion images from 27 SCD (age=65.3+/-8.0), 35 aMCI (age=69.2+/-8.6) and 25 AD patients (age=68.3+/-9.4) and 37 normal controls (NC) (age=65.1+/-6.8) were compared using Tract-Based Spatial Statistics (TBSS). WM impairments common to the three patient groups were extracted, and fractional anisotropy (FA) values were averaged in each group. As compared to NC subjects, SCD patients displayed widespread WM alterations represented by decreased FA (p<0.05), increased mean diffusivity (MD; p<0.05), and increased radial diffusivity (RD; p<0.05). In addition, localized WM alterations showed increased axial diffusivity (AxD; p<0.05) similar to what was observed in aMCI and AD patients (p<0.05). In the shared WM impairment tracts, SCD patients had FA values between the NC group and the other two patient groups. In the NC and SCD groups, the AVLT-delayed recall score correlated with higher AxD (r=-0.333, p=0.045), MD (r=-0.351, p=0.03) and RD (r=-0.353, p=0.025). In both the aMCI and AD groups the diffusion parameters were highly correlated with cognitive scores. Our study suggests that SCD patients present with widespread WM changes, which may contribute to the early memory decline they experience.
KeywordSubjective Cognitive Decline Diffusion Tensor Imaging Preclinical Alzheimer's Disease White Matter Tract-based Spatial Statistics
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(31371007 ; Beijing Municipal Science & Technology Commission(Z131100006813022) ; Kallikrein Medical Research Program(201206006) ; National Key Department of Neurology - Chinese Health and Family Planning Committee ; 81430037 ; 30970823 ; 81501549)
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000385435000026
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Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorZhenyu Liu
Affiliation1.Capital Med Univ, XuanWu Hosp, Dept Neurol, Beijing 100053, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Shandong Univ, Sch Mech Elect & Informat Engn, Weihai 264209, Shandong, Peoples R China
4.Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing 100053, Peoples R China
Recommended Citation
GB/T 7714
Li, Xuan-yu,Tang, Zhen-chao,Sun, Yu,et al. White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study[J]. ONCOTARGET,2016,7(34):54405-54414.
APA Li, Xuan-yu.,Tang, Zhen-chao.,Sun, Yu.,Tian, Jie.,Liu, Zhen-yu.,...&Zhenyu Liu.(2016).White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study.ONCOTARGET,7(34),54405-54414.
MLA Li, Xuan-yu,et al."White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study".ONCOTARGET 7.34(2016):54405-54414.
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