Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy

doi:10.1364/BOE.7.001830

	Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy
	Shi, Yiwen 1; Peng, Dong 2,3; Wang, Kun3 ; Chai, Xinyu 1; Ren, Qiushi 4; Tian, Jie 2,3; Zhou, Chuanqing 1
发表期刊	BIOMEDICAL OPTICS EXPRESS
	2016-05-01
卷号	7 期号:5 页码:1830-1841
文章类型	Article
摘要	Optimizing contrast enhancement is essential for producing specific signals in biomedical imaging and therapy. The potential of using Au-core-Ag-shell nanorods (Au@Ag NRs) as a dual-functional theranostic contrast agent is demonstrated for effective cancer imaging and treatments. Due to its strong NIR absorption and high efficiency of photothermal conversion, effects of both photoacoustic tomography (PAT) and photothermal therapy (PTT) are enhanced significantly. The PAT signal grows by 45.3% and 82% in the phantom and in vivo experiments, respectively, when compared to those using Au NRs. In PTT, The maximum increase of tissue temperature treated with Au@Ag NRs is 22.8 degrees C, twice that with Au NRs. Results of the current study show the feasibility of using Au@Ag NRs for synergetic PAT with PTT. And it will enhance the potential application on real-time PAT guided PTT, which will greatly benefit the customized PTT treatment of cancer. (C) 2016 Optical Society of America
关键词	Photoacoustic Imaging Photothermal Effects Image Enhancement Medical And Biological Imaging Nanomaterials
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI	10.1364/BOE.7.001830
关键词[WOS]	COATED GOLD NANORODS ; SILVER NANOPARTICLES ; SHELL NANORODS ; CANCER-CELLS ; NANOSPHERES ; TOMOGRAPHY ; NANOSILVER ; RELEASE ; SURFACE ; IONS
收录类别	SCI
语种	英语
项目资助者	National Basic Research Program of China(2010CB933903 ; National Natural Science Foundation of China(81171377 ; Chinese Academy of Sciences(YZ201359) ; 2014CB748600 ; 81470083) ; 2015CB755500)
WOS研究方向	Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000374745200016
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/12216
专题	中国科学院分子影像重点实验室
通讯作者	Zhou, Chuanqing
作者单位	1.Shanghai Jiao Tong Univ, Dept Biomed Engn, Shanghai 200240, Peoples R China 2.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Shi, Yiwen,Peng, Dong,Wang, Kun,et al. Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy[J]. BIOMEDICAL OPTICS EXPRESS,2016,7(5):1830-1841.
APA	Shi, Yiwen.,Peng, Dong.,Wang, Kun.,Chai, Xinyu.,Ren, Qiushi.,...&Zhou, Chuanqing.(2016).Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy.BIOMEDICAL OPTICS EXPRESS,7(5),1830-1841.
MLA	Shi, Yiwen,et al."Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy".BIOMEDICAL OPTICS EXPRESS 7.5(2016):1830-1841.

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