Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy | |
Shi, Yiwen1; Peng, Dong2,3; Wang, Kun3 ; Chai, Xinyu1; Ren, Qiushi4; Tian, Jie2,3; Zhou, Chuanqing1
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| Source Publication | BIOMEDICAL OPTICS EXPRESS
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| 2016-05-01 | |
| Volume | 7Issue:5Pages:1830-1841 |
| Subtype | Article |
| Abstract | Optimizing contrast enhancement is essential for producing specific signals in biomedical imaging and therapy. The potential of using Au-core-Ag-shell nanorods (Au@Ag NRs) as a dual-functional theranostic contrast agent is demonstrated for effective cancer imaging and treatments. Due to its strong NIR absorption and high efficiency of photothermal conversion, effects of both photoacoustic tomography (PAT) and photothermal therapy (PTT) are enhanced significantly. The PAT signal grows by 45.3% and 82% in the phantom and in vivo experiments, respectively, when compared to those using Au NRs. In PTT, The maximum increase of tissue temperature treated with Au@Ag NRs is 22.8 degrees C, twice that with Au NRs. Results of the current study show the feasibility of using Au@Ag NRs for synergetic PAT with PTT. And it will enhance the potential application on real-time PAT guided PTT, which will greatly benefit the customized PTT treatment of cancer. (C) 2016 Optical Society of America |
| Keyword | Photoacoustic Imaging Photothermal Effects Image Enhancement Medical And Biological Imaging Nanomaterials |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| DOI | 10.1364/BOE.7.001830 |
| WOS Keyword | COATED GOLD NANORODS ; SILVER NANOPARTICLES ; SHELL NANORODS ; CANCER-CELLS ; NANOSPHERES ; TOMOGRAPHY ; NANOSILVER ; RELEASE ; SURFACE ; IONS |
| Indexed By | SCI |
| Language | 英语 |
| Funding Organization | National Basic Research Program of China(2010CB933903 ; National Natural Science Foundation of China(81171377 ; Chinese Academy of Sciences(YZ201359) ; 2014CB748600 ; 81470083) ; 2015CB755500) |
| WOS Research Area | Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS Subject | Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS ID | WOS:000374745200016 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/12216 |
| Collection | 中国科学院分子影像重点实验室 |
| Corresponding Author | Zhou, Chuanqing |
| Affiliation | 1.Shanghai Jiao Tong Univ, Dept Biomed Engn, Shanghai 200240, Peoples R China 2.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China |
| Recommended Citation GB/T 7714 | Shi, Yiwen,Peng, Dong,Wang, Kun,et al. Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy[J]. BIOMEDICAL OPTICS EXPRESS,2016,7(5):1830-1841. |
| APA | Shi, Yiwen.,Peng, Dong.,Wang, Kun.,Chai, Xinyu.,Ren, Qiushi.,...&Zhou, Chuanqing.(2016).Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy.BIOMEDICAL OPTICS EXPRESS,7(5),1830-1841. |
| MLA | Shi, Yiwen,et al."Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy".BIOMEDICAL OPTICS EXPRESS 7.5(2016):1830-1841. |
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| File Name/Size | DocType | Version | Access | License | ||
| 1830.pdf（3934KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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