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The Implication of Frontostriatal Circuits in Young Smokers: A Resting-State Study
Yuan, Kai1,2,3; Yu, Dahua3; Bi, Yanzhi1,2; Li, Yangding1,2; Guan, Yanyan1,2; Liu, Jixin1,2; Zhang, Yi1,2; Qin, Wei1,2; Lu, Xiaoqi3; Tian, Jie1,2,4
AbstractThe critical roles of frontostriatal circuits had been revealed in addiction. With regard to young smokers, the implication of frontostriatal circuits resting-state functional connectivity (RSFC) in smoking behaviors and cognitive control deficits remains unclear. In this study, the volume of striatum subsets, i.e., caudate, putamen, and nucleus accumbens, and corresponding RSFC differences were investigated between young smokers (n(1) = 60) and nonsmokers (n(2) = 60), which were then correlated with cigarette smoking measures, such as pack_years-cumulative effect of smoking, Fagerstrom Test for Nicotine Dependence (FTND)-severity of nicotine addiction, Questionnaire on Smoking Urges (QSU)-craving state, and Stroop task performances. Additionally, mediation analysis was carried out to test whether the frontostriatal RSFC mediates the relationship between striatum morphometry and cognitive control behaviors in young smokers when applicable. We revealed increased volume of right caudate and reduced RSFC between caudate and dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex in young smokers. Significant positive correlation between right caudate volume and QSU as well as negative correlation between anterior cingulate cortex-right caudate RSFC and FTND were detected in young smokers. More importantly, DLPFC-caudate RSFC strength mediated the relationship between caudate volume and incongruent errors during Stroop task in young smokers. Our results demonstrated that young smokers showed abnormal interactions within frontostriatal circuits, which were associated with smoking behaviors and cognitive control impairments. It is hoped that our study focusing on frontostriatal circuits could provide new insights into the neural correlates and potential novel therapeutic targets for treatment of young smokers. (C) 2016 Wiley Periodicals, Inc.
KeywordYoung Smokers Striatum Frontostriatal Circuits Cognitive Control Resting-state Functional Connectivity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(81571751 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ4118) ; Fundamental Research Funds for the Central Universities(JB151204 ; Natural Science Foundation of Inner Mongolia(2014BS0610) ; Innovation Fund Project of Inner Mongolia University of Science and Technology(2015QNGG03 ; China Post-doctoral Science Foundation(2014M552416) ; 81571753 ; JB121405) ; 2014QDL002) ; 61502376 ; 81401478 ; 81401488 ; 81470816 ; 81471737 ; 81301281 ; 81271546 ; 81271549)
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000382486500001
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Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China
3.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Informat Proc Lab, Baotou 014010, Inner Mongolia, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Kai,Yu, Dahua,Bi, Yanzhi,et al. The Implication of Frontostriatal Circuits in Young Smokers: A Resting-State Study[J]. HUMAN BRAIN MAPPING,2016,37(6):2013-2026.
APA Yuan, Kai.,Yu, Dahua.,Bi, Yanzhi.,Li, Yangding.,Guan, Yanyan.,...&Tian, Jie.(2016).The Implication of Frontostriatal Circuits in Young Smokers: A Resting-State Study.HUMAN BRAIN MAPPING,37(6),2013-2026.
MLA Yuan, Kai,et al."The Implication of Frontostriatal Circuits in Young Smokers: A Resting-State Study".HUMAN BRAIN MAPPING 37.6(2016):2013-2026.
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