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Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects
Ma, Guangyang1,2,3,4; Yang, Dan1,2,5; Qin, Wen1,2; Liu, Yong6; Jiang, Tianzi6; Yu, Chunshui1,2; Yu Chunshui
2017-01-10
发表期刊FRONTIERS IN NEUROSCIENCE
卷号10期号:10页码:612
文章类型Article
摘要The hippocampus has exhibited navigation-related changes in volume and activity after visual deprivation; however, the resting-state functional connectivity (rsFC) changes of the hippocampus in the blind remains unknown. In this study, we focused on sub-region-specific rsFC changes of the hippocampus and their association with the onset age of blindness. The rsFC patterns of the hippocampal sub-regions (head, body and tail) were compared among 20 congenitally blind (CB), 42 late blind (LB), and 50 sighted controls (SC). Compared with the SC, both the CB and the LB showed increased hippocampal rsFCs with the posterior cingulate cortex, angular gyrus, parieto-occpital sulcus, middle occipito-temporal conjunction, inferior temporal gyrus, orbital frontal cortex, and middle frontal gyrus. In the blind subjects, the hippocampal tail had more extensive rsFC changes than the anterior hippocampus (body and head). The CB and the LB had similar changes in hippocampal rsFC. These altered rsFCs of the hippocampal sub-regions were neither correlated with onset age in the LB nor the duration of blindness in CB or LB subjects. The increased coupling of the hippocampal intrinsic functional network may reflect enhanced loading of the hippocampal-related networks for non-visual memory processing. Furthermore, the similar changes of hippocampal rsFCs between the CB and the LB suggests an experience-dependent rather than a developmental-dependent plasticity of the hippocampal intrinsic functional network.
关键词Functional Connectivity Hippocampus Congenitally Blind Late Blind Resting State
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.3389/fnins.2016.00612
关键词[WOS]VISUAL-CORTEX ; ORBITOFRONTAL CORTEX ; SPATIAL REPRESENTATION ; AUDITORY LOCALIZATION ; DEVELOPMENTAL VISION ; OCCIPITAL CORTEX ; PARIETAL CORTEX ; PLACE CELLS ; LATE-ONSET ; CONNECTIVITY
收录类别SCI ; SSCI
语种英语
项目资助者National Natural Science Foundation of China(81401394 ; 81425013 ; 91332113 ; 81270020 ; 81271551)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000391497800002
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/13200
专题脑网络组研究中心
通讯作者Yu Chunshui
作者单位1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct imaging, Tianjin, Peoples R China
3.Tianjin Med Univ, Key Lab Hormones & Dev, Minist Hlth, Tianjin Key Lab Metab Dis,Tianjin Metab Dis Hosp, Tianjin, Peoples R China
4.Tianjin Med Univ, Tianjin Inst Endocrinol, Tianjin, Peoples R China
5.Tianjin Cent Hosp Gynecol Obstet, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
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GB/T 7714
Ma, Guangyang,Yang, Dan,Qin, Wen,et al. Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects[J]. FRONTIERS IN NEUROSCIENCE,2017,10(10):612.
APA Ma, Guangyang.,Yang, Dan.,Qin, Wen.,Liu, Yong.,Jiang, Tianzi.,...&Yu Chunshui.(2017).Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects.FRONTIERS IN NEUROSCIENCE,10(10),612.
MLA Ma, Guangyang,et al."Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects".FRONTIERS IN NEUROSCIENCE 10.10(2017):612.
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