Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects

doi:10.3389/fnins.2016.00612

	Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects
	Ma, Guangyang 1,2,3,4; Yang, Dan 1,2,5; Qin, Wen 1,2; Liu, Yong6 ; Jiang, Tianzi6 ; Yu, Chunshui 1,2; Yu Chunshui
发表期刊	FRONTIERS IN NEUROSCIENCE
	2017-01-10
卷号	10 期号:10 页码:612
文章类型	Article
摘要	The hippocampus has exhibited navigation-related changes in volume and activity after visual deprivation; however, the resting-state functional connectivity (rsFC) changes of the hippocampus in the blind remains unknown. In this study, we focused on sub-region-specific rsFC changes of the hippocampus and their association with the onset age of blindness. The rsFC patterns of the hippocampal sub-regions (head, body and tail) were compared among 20 congenitally blind (CB), 42 late blind (LB), and 50 sighted controls (SC). Compared with the SC, both the CB and the LB showed increased hippocampal rsFCs with the posterior cingulate cortex, angular gyrus, parieto-occpital sulcus, middle occipito-temporal conjunction, inferior temporal gyrus, orbital frontal cortex, and middle frontal gyrus. In the blind subjects, the hippocampal tail had more extensive rsFC changes than the anterior hippocampus (body and head). The CB and the LB had similar changes in hippocampal rsFC. These altered rsFCs of the hippocampal sub-regions were neither correlated with onset age in the LB nor the duration of blindness in CB or LB subjects. The increased coupling of the hippocampal intrinsic functional network may reflect enhanced loading of the hippocampal-related networks for non-visual memory processing. Furthermore, the similar changes of hippocampal rsFCs between the CB and the LB suggests an experience-dependent rather than a developmental-dependent plasticity of the hippocampal intrinsic functional network.
关键词	Functional Connectivity Hippocampus Congenitally Blind Late Blind Resting State
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.3389/fnins.2016.00612
关键词[WOS]	VISUAL-CORTEX ; ORBITOFRONTAL CORTEX ; SPATIAL REPRESENTATION ; AUDITORY LOCALIZATION ; DEVELOPMENTAL VISION ; OCCIPITAL CORTEX ; PARIETAL CORTEX ; PLACE CELLS ; LATE-ONSET ; CONNECTIVITY
收录类别	SCI ; SSCI
语种	英语
项目资助者	National Natural Science Foundation of China(81401394 ; 81425013 ; 91332113 ; 81270020 ; 81271551)
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000391497800002
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/13200
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Yu Chunshui
作者单位	1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin, Peoples R China 2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct imaging, Tianjin, Peoples R China 3.Tianjin Med Univ, Key Lab Hormones & Dev, Minist Hlth, Tianjin Key Lab Metab Dis,Tianjin Metab Dis Hosp, Tianjin, Peoples R China 4.Tianjin Med Univ, Tianjin Inst Endocrinol, Tianjin, Peoples R China 5.Tianjin Cent Hosp Gynecol Obstet, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Ma, Guangyang,Yang, Dan,Qin, Wen,et al. Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects[J]. FRONTIERS IN NEUROSCIENCE,2017,10(10):612.
APA	Ma, Guangyang.,Yang, Dan.,Qin, Wen.,Liu, Yong.,Jiang, Tianzi.,...&Yu Chunshui.(2017).Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects.FRONTIERS IN NEUROSCIENCE,10(10),612.
MLA	Ma, Guangyang,et al."Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects".FRONTIERS IN NEUROSCIENCE 10.10(2017):612.