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Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects
Ma, Guangyang1,2,3,4; Yang, Dan1,2,5; Qin, Wen1,2; Liu, Yong6; Jiang, Tianzi6; Yu, Chunshui1,2; Yu Chunshui
Source PublicationFRONTIERS IN NEUROSCIENCE
2017-01-10
Volume10Issue:10Pages:612
SubtypeArticle
AbstractThe hippocampus has exhibited navigation-related changes in volume and activity after visual deprivation; however, the resting-state functional connectivity (rsFC) changes of the hippocampus in the blind remains unknown. In this study, we focused on sub-region-specific rsFC changes of the hippocampus and their association with the onset age of blindness. The rsFC patterns of the hippocampal sub-regions (head, body and tail) were compared among 20 congenitally blind (CB), 42 late blind (LB), and 50 sighted controls (SC). Compared with the SC, both the CB and the LB showed increased hippocampal rsFCs with the posterior cingulate cortex, angular gyrus, parieto-occpital sulcus, middle occipito-temporal conjunction, inferior temporal gyrus, orbital frontal cortex, and middle frontal gyrus. In the blind subjects, the hippocampal tail had more extensive rsFC changes than the anterior hippocampus (body and head). The CB and the LB had similar changes in hippocampal rsFC. These altered rsFCs of the hippocampal sub-regions were neither correlated with onset age in the LB nor the duration of blindness in CB or LB subjects. The increased coupling of the hippocampal intrinsic functional network may reflect enhanced loading of the hippocampal-related networks for non-visual memory processing. Furthermore, the similar changes of hippocampal rsFCs between the CB and the LB suggests an experience-dependent rather than a developmental-dependent plasticity of the hippocampal intrinsic functional network.
KeywordFunctional Connectivity Hippocampus Congenitally Blind Late Blind Resting State
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.3389/fnins.2016.00612
WOS KeywordVISUAL-CORTEX ; ORBITOFRONTAL CORTEX ; SPATIAL REPRESENTATION ; AUDITORY LOCALIZATION ; DEVELOPMENTAL VISION ; OCCIPITAL CORTEX ; PARIETAL CORTEX ; PLACE CELLS ; LATE-ONSET ; CONNECTIVITY
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81401394 ; 81425013 ; 91332113 ; 81270020 ; 81271551)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000391497800002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/13200
Collection脑网络组研究中心
Corresponding AuthorYu Chunshui
Affiliation1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct imaging, Tianjin, Peoples R China
3.Tianjin Med Univ, Key Lab Hormones & Dev, Minist Hlth, Tianjin Key Lab Metab Dis,Tianjin Metab Dis Hosp, Tianjin, Peoples R China
4.Tianjin Med Univ, Tianjin Inst Endocrinol, Tianjin, Peoples R China
5.Tianjin Cent Hosp Gynecol Obstet, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Ma, Guangyang,Yang, Dan,Qin, Wen,et al. Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects[J]. FRONTIERS IN NEUROSCIENCE,2017,10(10):612.
APA Ma, Guangyang.,Yang, Dan.,Qin, Wen.,Liu, Yong.,Jiang, Tianzi.,...&Yu Chunshui.(2017).Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects.FRONTIERS IN NEUROSCIENCE,10(10),612.
MLA Ma, Guangyang,et al."Enhanced Functional Coupling of Hippocampal Sub-regions in Congenitally and Late Blind Subjects".FRONTIERS IN NEUROSCIENCE 10.10(2017):612.
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