Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle

doi:10.1021/acsami.6b06883

	Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle
	Zeng, Chaoting 1,2; Shang, Wenting1,3 ; Liang, Xiaoyuan 1,2; Liang, Xiao1,3 ; Chen, Qingshan 1,2; Chi, Chongwei1,3 ; Du, Yang1,3 ; Fang, Chihua 2; Tian, Jie 1,3
发表期刊	ACS APPLIED MATERIALS & INTERFACES
	2016-11-02
卷号	8 期号:43 页码:29232-29241
文章类型	Article
摘要	To improve patient outcome and decrease overall health-care costs, highly sensitive and precise detection of a tumor is required for its accurate diagnosis and efficient therapy; however, this remains a challenge when using conventional single mode imaging. Here, we successfully designed a near infrared (NIR)-response photothermal therapy (PTT) platform (Au@MSNs-ICG) for the location, diagnosis, and NIR/computer tomography (CT) bimodal imaging-guided PTT of tumor tissues, using gold (Au) nanospheres coated with indocyanine green (ICG)-loaded mesoporous silica nanoparticles (MSNs), which would have high sensitivity and precision. The nanoparticles (NPs) exhibited good monodispersity, fluorescence stability, biocompatibility, and NIR/CT signaling and had a preferable temperature response under MR laser irradiation in vitro or in vivo. Using a combination of NIR/CT imaging and PTT treatment, the tumor could be accurately positioned and thoroughly eradicated in vivo by Au@MSNs-ICG injection. Hence, the multifunctional NPs could play an important role in facilitating the accurate treatment of tumors in future clinical applications.
关键词	Gold Nanospheres Indocyanine Green Computed Tomography Nir Fluorescence Imaging Photothermal Therapy Imaging-guided Therapy
WOS标题词	Science & Technology ; Technology
DOI	10.1021/acsami.6b06883
关键词[WOS]	RAY-COMPUTED-TOMOGRAPHY ; TARGETED GOLD NANOPARTICLES ; NEGATIVE BREAST-CANCER ; LARGE-SCALE SYNTHESIS ; INDOCYANINE-GREEN ; IN-VIVO ; CONTRAST AGENTS ; MESOPOROUS SILICA ; MAGNETIC-RESONANCE ; LUNG-CANCER
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(81227901 ; National High Technology Research and Development Program of China (863 Program)(2012AA021105) ; Guangdong provincial science and technology plan projects(2014A020212647) ; Cultivation of Guangdong College Students' Scientific and Technological Innovation project ("Climbing Program" Special Funds)(pdjh2016b0103 ; 81501540 ; pdjh2016a0090) ; 61231004 ; U1401254 ; 61401462 ; 61501462 ; 81527805 ; 81470083)
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000387095300007
引用统计	被引频次：69[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/13342
专题	中国科学院分子影像重点实验室
作者单位	1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, 253 Gongye Ave, Guangzhou 510280, Guangdong, Peoples R China 3.Beijing Key Lab Mol Imaging, Zhongguancun East Rd 95, Beijing 100190, Peoples R China
第一作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Zeng, Chaoting,Shang, Wenting,Liang, Xiaoyuan,et al. Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(43):29232-29241.
APA	Zeng, Chaoting.,Shang, Wenting.,Liang, Xiaoyuan.,Liang, Xiao.,Chen, Qingshan.,...&Tian, Jie.(2016).Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle.ACS APPLIED MATERIALS & INTERFACES,8(43),29232-29241.
MLA	Zeng, Chaoting,et al."Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle".ACS APPLIED MATERIALS & INTERFACES 8.43(2016):29232-29241.

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