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MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles
Qiao, Hongyu1,2; Wang, Yabin1; Zhang, Ruohan3; Gao, Quansheng6; Liang, Xiao4; Gao, Lei1; Jiang, Zhenhua2; Qiao, Ruirui5; Han, Dong2; Zhang, Yan1; Qiu, Ya1; Tian, Jie4; Gao, Mingyuan5; Cao, Feng1,2
2017
发表期刊BIOMATERIALS
卷号112页码:336-345
文章类型Article
摘要Rupture of vulnerable atherosclerotic plaque is the major pathological cause of luminal thrombosis in acute coronary syndromes. Since foamy macrophages have been identified as a prominent component in vulnerable atherosclerotic lesions and osteopontin (OPN) is reported to be highly expressed in foamy macrophages, OPN could be a potential target for vulnerable atherosclerotic plaque imaging. The current study designed an OPN-specific MRI/optical dual-modality probe to detect vulnerable plaques. Fluorescence imaging revealed that 24 h after injection of the Cy5.5-OPN-DMSA-MNPs (COD-MNPs), the atherosclerotic plaques in carotid artery exhibited significant higher signals in high fat diet (HFD) fed mice in comparison to the group injected with Cy5.5-IgG-DMSA-MNPs (CID-MNPs) or normal diet fed group injected with COD-MNPs (1.87 +/- 0.19 x 10(10) vs. 0.74 +/- 0.04 x 10(10), 0.73 +/- 0.03 x 10(10) p/sec/cm(2)/sr, P < 0.05). Meanwhile, MRI displayed stronger T-2 contrast enhancement 24 h post-injection at the area of atherosclerotic plaques in the carotid of HFD fed group injected with COD-MNPs than group injected with CID-MNPs or normal diet fed group injected with COD-MNPs (post/pre signal ratio: 0.64 +/- 0.04 vs. 0.95 +/- 0.02, 0.98 +/- 0.01, P < 0.05). As a dual-modality molecular probe, the resulting COD-MNPs conjugates exhibit promising potentials for noninvasive detection of vulnerable atherosclerotic plaque in vivo. (C) 2016 Elsevier Ltd. All rights reserved.
关键词Dual-modality Molecular Imaging Atherosclerotic Plaques Macrophages Nanoparticles
WOS标题词Science & Technology ; Technology
DOI10.1016/j.biomaterials.2016.10.011
关键词[WOS]CONTRAST-ENHANCED ULTRASOUND ; CORONARY-ARTERY-DISEASE ; MAGNETIC-RESONANCE ; IN-VIVO ; IRON-OXIDE ; FUTURE-DIRECTIONS ; TRANSGENIC MICE ; DEFICIENT MICE ; SMOOTH-MUSCLE ; MACROPHAGE
收录类别SCI
语种英语
项目资助者National Key Research Program of China(2016YFA0100903) ; National Funds for Distinguished Young Scientists of China(81325009) ; National Nature Science Foundation of China(81500360 ; Beijing Nature Science Foundation(7152131) ; China Postdoctoral Science Foundation(2016790990) ; 81671731 ; 81530058 ; 81570272)
WOS研究方向Engineering ; Materials Science
WOS类目Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号WOS:000389166700029
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/13365
专题中国科学院分子影像重点实验室
作者单位1.Chinese PM Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China
2.Dept Cardiol, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China
3.Fourth Mil Med Univ, Xijing Hosp, Dept Hepatobiliary & Pancretosplen Surg, Xian 710032, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China
6.Acad Mil Med Sci, Lab Anim Ctr, Beijing 100850, Peoples R China
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Qiao, Hongyu,Wang, Yabin,Zhang, Ruohan,et al. MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles[J]. BIOMATERIALS,2017,112:336-345.
APA Qiao, Hongyu.,Wang, Yabin.,Zhang, Ruohan.,Gao, Quansheng.,Liang, Xiao.,...&Cao, Feng.(2017).MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles.BIOMATERIALS,112,336-345.
MLA Qiao, Hongyu,et al."MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles".BIOMATERIALS 112(2017):336-345.
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