In Situ Growth Strategy to Integrate Up-Conversion Nanoparticles with Ultrasmall CuS for Photothermal Theranostics

doi:10.1021/acsnano.6b07990

	In Situ Growth Strategy to Integrate Up-Conversion Nanoparticles with Ultrasmall CuS for Photothermal Theranostics
	Lv, Ruichan 1,2,4; Yang, Piaoping 2; Hu, Bo 1; Xu, Jiating 2; Shang, Wenting3 ; Tian, Jie 1,3
发表期刊	ACS NANO
	2017
卷号	11 期号:1 页码:1064-1072
文章类型	Article
摘要	In the theranostic field, a near-infrared (NIR) laser is located in the optical window, and up-conversion nanoparticles (UCNPs) could be potentially utilized as the imaging agents with high contrast. Meanwhile, copper sulfide (CuS) has been proposed as a photothermal agent with increased temperature under a NIR laser. However, there is still no direct and effective strategy to integrate the hydrophobic UCNPs with CuS until now. Herein, we propose an in situ growth routine based on the hydrophobic core/shell UCNPs combined with ultrasmall water-soluble CuS triggered by single 808 run MR irradiation as the theranostic platform. Hydrophobic NaYF4:Yb,Er@NaYF4,Nd,Yb could be turned hydrophilic with highly dispersed and biocompatible properties through conjunction with transferred dopamine. The as-synthesized ultrasmall CuS (3 and 7 nm) served as a stable photothermal agent even after several laser-on/off cycles. Most importantly, comparing with the mix routine, the in situ growth routine to coat UCNPs with CuS is meaningful, and the platform is uniform and stable. Green luminescence-guided hyperthermia could be achieved under a single 808 nm laser, which was evidenced by in vitro and in vivo assays. This nanoplatform is applicable as a bioimaging and photothermal antitumor agent, and the in situ growth routine could be spread to other integration processes.
关键词	Up-conversion Copper Sulfide In Situ Growth Photothermal
WOS标题词	Science & Technology ; Physical Sciences ; Technology
DOI	10.1021/acsnano.6b07990
关键词[WOS]	NEAR-INFRARED-LIGHT ; CORE-SHELL NANOPARTICLES ; UPCONVERTING NANOPARTICLES ; LUMINESCENCE ENHANCEMENT ; BIOMEDICAL APPLICATIONS ; THERAPY ; VIVO ; TUMOR ; NANORODS ; PLATFORM
收录类别	SCI
语种	英语
项目资助者	Natural Science Foundation of China(NSFC 21271053 ; Alexander von Humboldt Foundation ; 21401032 ; 51472058 ; 51332008 ; 51502050)
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000392886500112
引用统计	被引频次：133[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/14369
专题	中国科学院分子影像重点实验室
作者单位	1.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Sch Life Sci & Technol, Xian 710071, Shanxi, Peoples R China 2.Harbin Engn Univ, Coll Mat Sci & Chem Engn, Minist Educ, Key Lab Superlight Mat & Surface Technol, Harbin 150001, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Philipps Univ Marburg, Fachbereich Phys, D-35037 Marburg, Germany
推荐引用方式 GB/T 7714	Lv, Ruichan,Yang, Piaoping,Hu, Bo,et al. In Situ Growth Strategy to Integrate Up-Conversion Nanoparticles with Ultrasmall CuS for Photothermal Theranostics[J]. ACS NANO,2017,11(1):1064-1072.
APA	Lv, Ruichan,Yang, Piaoping,Hu, Bo,Xu, Jiating,Shang, Wenting,&Tian, Jie.(2017).In Situ Growth Strategy to Integrate Up-Conversion Nanoparticles with Ultrasmall CuS for Photothermal Theranostics.ACS NANO,11(1),1064-1072.
MLA	Lv, Ruichan,et al."In Situ Growth Strategy to Integrate Up-Conversion Nanoparticles with Ultrasmall CuS for Photothermal Theranostics".ACS NANO 11.1(2017):1064-1072.

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