Precise integrin-targeting near-infrared imaging-guided surgical method increases surgical qualification of peritoneal carcinomatosis from gastric cancer in mice

doi:10.18632/oncotarget.14058

	Precise integrin-targeting near-infrared imaging-guided surgical method increases surgical qualification of peritoneal carcinomatosis from gastric cancer in mice
	Cheng, Haidong 1,2,3; Chi, Chongwei3 ; Shang, Wenting3 ; Sha Rengaowa 4; Cui, Jianxin 1; Ye, Jinzuo3 ; Jiang, Shixin 3; Mao, Yamin3 ; Zeng, Caoting 5; Huo, Huiping 6; Chen, Lin1 ; Tian, Jie 3
发表期刊	ONCOTARGET
	2017
卷号	8 期号:4 页码:6258-6272
文章类型	Article
摘要	Peritoneal carcinomatosis from gastric cancer represents a common recurrent gastric cancer that seriously affects the survival, prognosis, and quality of life of patients at its advanced stage. In recent years, complete cytoreduction surgery in combination with hyperthermic intraperitoneal chemotherapy has been demonstrated to improve the survival and prognosis of patients with malignant tumors including peritoneal carcinomatosis from gastric cancer. Establishing viable methods of accurately assessing the tumor burden in patients with peritoneal carcinoma and correctly selecting suitable patients in order to improve cytoreduction surgical outcomes and reduce the risk of postoperative complications has become a challenge in the field of peritoneal carcinoma research. Here, we investigated peritoneal carcinomatosis from gastric cancer in a mouse model by using our self-developed surgical navigation system that combines optical molecular imaging with an integrin-targeting Arg-Gly-Asp-indocyanine green (RGD-ICG) molecular probe. The results showed that our diagnostic method could achieve a sensitivity and specificity of up to 93.93% and 100%, respectively, with a diagnostic index (DI) of 193.93% and diagnostic accuracy rate of 93.93%. Furthermore, the minimum tumor diameter measured during the surgery was 1.8 mm and the operative time was shortened by 3.26-fold when compared with the conventionally-treated control group. Therefore, our surgical navigation system that combines optical molecular imaging with an RGD-ICG molecular probe, could improve the diagnostic accuracy rate for peritoneal carcinomatosis from gastric cancer, shorten the operative time, and improve the quality of the cytoreduction surgery for peritoneal carcinomatosis from gastric cancer, thus providing a solid foundation for its future clinical development and application.
关键词	Gastric Cancer Fluorescence Molecular Imaging Peritoneal Carcinomatosis Integrin
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.18632/oncotarget.14058
关键词[WOS]	HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY ; CYTOREDUCTIVE SURGERY ; OVARIAN-CANCER ; BREAST-CANCER ; METASTASIS ; ALPHA(V)BETA(3) ; MANAGEMENT ; CHEMOHYPERTHERMIA ; MALIGNANCIES ; STATISTICS
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(81227901 ; Instrument Developing Project of the Chinese Academy of Sciences(YZ201359) ; 61231004 ; 81470083 ; 61501462)
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000393289000072
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/14371
专题	中国科学院分子影像重点实验室
作者单位	1.Chinese Peoples Liberat Army Gen Hosp, Dept Gen Surg, Beijing, Peoples R China 2.Inner Mongolia Med Univ, Affiliated Hosp 1, Dept Gen Surg, Hohhot 010059, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Inner Mongolia Med Univ, Dept Basic Med Sci, Hohhot 010059, Peoples R China 5.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China 6.Peoples Liberat Army, Gen Hosp, Dept Ultrasound, Beijing, Peoples R China
第一作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Cheng, Haidong,Chi, Chongwei,Shang, Wenting,et al. Precise integrin-targeting near-infrared imaging-guided surgical method increases surgical qualification of peritoneal carcinomatosis from gastric cancer in mice[J]. ONCOTARGET,2017,8(4):6258-6272.
APA	Cheng, Haidong.,Chi, Chongwei.,Shang, Wenting.,Sha Rengaowa.,Cui, Jianxin.,...&Tian, Jie.(2017).Precise integrin-targeting near-infrared imaging-guided surgical method increases surgical qualification of peritoneal carcinomatosis from gastric cancer in mice.ONCOTARGET,8(4),6258-6272.
MLA	Cheng, Haidong,et al."Precise integrin-targeting near-infrared imaging-guided surgical method increases surgical qualification of peritoneal carcinomatosis from gastric cancer in mice".ONCOTARGET 8.4(2017):6258-6272.

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