CASIA OpenIR  > 脑网络组研究中心
Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution
Shi, Lei1; Hu, Enzhi1,2; Wang, Zhenbo3; Liu, Jiewei1,2; Li, Jin4,5; Li, Ming1,6; Chen, Hua7; Yu, Chunshui8,9; Jiang, Tianzi3,10,11,12; Su, Bing1
2017-02-01
发表期刊HUMAN GENETICS
卷号136期号:2页码:193-204
文章类型Article
摘要Human evolution is marked by a continued enlargement of the brain. Previous studies on human brain evolution focused on identifying sequence divergences of brain size regulating genes between humans and nonhuman primates. However, the evolutionary pattern of the brain size regulating genes during recent human evolution is largely unknown. We conducted a comprehensive analysis of the brain size regulating gene CASC5 and found that in recent human evolution, CASC5 has accumulated many modern human specific amino acid changes, including two fixed changes and six polymorphic changes. Among human populations, 4 of the 6 amino acid polymorphic sites have high frequencies of derived alleles in East Asians, but are rare in Europeans and Africans. We proved that this between-population allelic divergence was caused by regional Darwinian positive selection in East Asians. Further analysis of brain image data of Han Chinese showed significant associations of the amino acid polymorphic sites with gray matter volume. Hence, CASC5 may contribute to the morphological and structural changes of the human brain during recent evolution. The observed between-population divergence of CASC5 variants was driven by natural selection that tends to favor a larger gray matter volume in East Asians.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1007/s00439-016-1748-5
关键词[WOS]CEREBRAL CORTICAL SIZE ; MAXIMUM-LIKELIHOOD ; MICROCEPHALY GENES ; MAJOR DETERMINANT ; PHYLOGENETIC ANALYSIS ; MOLECULAR EVOLUTION ; CENTROSOMAL PROTEIN ; ADAPTIVE EVOLUTION ; GENOME SEQUENCE ; MUTATIONS
收录类别SCI
语种英语
项目资助者Strategic Priority Research Program of the Chinese Academy of Sciences(XDB13010000) ; National Natural Science Foundation of China(31130051 ; Youth Innovation Promotion Association of CAS ; State Key Laboratory of Genetic Resources and Evolution(GREKF14-08) ; 31321002 ; 31123005 ; 31301028)
WOS研究方向Genetics & Heredity
WOS类目Genetics & Heredity
WOS记录号WOS:000393822400005
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/14384
专题脑网络组研究中心
作者单位1.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Peoples R China
2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Zool, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
6.Johns Hopkins Univ, Lieber Inst Brain Dev, Baltimore, MD USA
7.Chinese Acad Sci, Beijing Inst Genom, Ctr Computat Genom, Beijing 100101, Peoples R China
8.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
9.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China
10.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China
11.Univ Elect Sci & Technol China, Key Lab NeuroInformat, Minist Educ, Sch Life Sci & Technol, Chengdu, Peoples R China
12.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
推荐引用方式
GB/T 7714
Shi, Lei,Hu, Enzhi,Wang, Zhenbo,et al. Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution[J]. HUMAN GENETICS,2017,136(2):193-204.
APA Shi, Lei.,Hu, Enzhi.,Wang, Zhenbo.,Liu, Jiewei.,Li, Jin.,...&Su, Bing.(2017).Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution.HUMAN GENETICS,136(2),193-204.
MLA Shi, Lei,et al."Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution".HUMAN GENETICS 136.2(2017):193-204.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Shi, Lei]的文章
[Hu, Enzhi]的文章
[Wang, Zhenbo]的文章
百度学术
百度学术中相似的文章
[Shi, Lei]的文章
[Hu, Enzhi]的文章
[Wang, Zhenbo]的文章
必应学术
必应学术中相似的文章
[Shi, Lei]的文章
[Hu, Enzhi]的文章
[Wang, Zhenbo]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。