Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes

doi:10.1021/acsnano.6b07842

	Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes
	Qiao, Ruirui 1; Qiao, Hongyu 2,3; Zhang, Yan 2; Wang, Yabin 2; Chi, Chongwei4 ; Tian, Jie 4; Zhang, Lifang 1; Cao, Feng 2; Gao, Mingyuan 1
发表期刊	ACS NANO
	2017-02-01
卷号	11 期号:2 页码:1816-1825
文章类型	Article
摘要	Owing to the high mortality rate of cardiovascular diseases, developing novel noninvasive diagnostic methods becomes urgent and mandatory. It is well-known that the rupture of vulnerable plaques directly leads to deadly consequences. However, differentiating vulnerable plaques from stable plaques remains challenging in the clinic. In the current study, osteopontin (OPN), a secreted biomarker associated with macrophages and foamy macrophages, was selected as a target for identifying the vulnerable plaques. A dual modality imaging probe was constructed by covalently attaching an OPN antibody to NaGdF4:Yb,Er@NaGdF4 upconversion nanoparticles. Upon intravenous injection resulting probes, upconversion optical imaging was performed to visualize the plaques induced by altering the shear stress in carotid arteries of a mouse model. The imaging studies revealed that the signals of vulnerable and stable plagues induced by lowered shear stress and oscillatory shear stress, respectively, presented significantly different signal intensities, implying that the current probe and imaging strategy are potentially useful for a precise diagnosis of atherosclerosis plaques.
关键词	Vulnerable Plaques Macrophage Opn Molecular Imaging Upconversion Nanoparticle
WOS标题词	Science & Technology ; Physical Sciences ; Technology
DOI	10.1021/acsnano.6b07842
关键词[WOS]	SMOOTH-MUSCLE ; SHEAR-STRESS ; IRON-OXIDE ; NANOPARTICLES ; MACROPHAGE ; DISEASE ; MRI ; ATHEROMA ; CELLS
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(81571746 ; 81325009 ; 81530057 ; 81530058)
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000395357300075
引用统计	被引频次：89[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/14388
专题	中国科学院分子影像重点实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, 28 Fuxing Rd, Beijing 100853, Peoples R China 3.Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China 4.Chinese Acad Sci, Key Lab Mol Imaging, 95 Zhong Guan Cun East Rd, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Qiao, Ruirui,Qiao, Hongyu,Zhang, Yan,et al. Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes[J]. ACS NANO,2017,11(2):1816-1825.
APA	Qiao, Ruirui.,Qiao, Hongyu.,Zhang, Yan.,Wang, Yabin.,Chi, Chongwei.,...&Gao, Mingyuan.(2017).Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes.ACS NANO,11(2),1816-1825.
MLA	Qiao, Ruirui,et al."Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes".ACS NANO 11.2(2017):1816-1825.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
ACSNano_8.pdf（6308KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载