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Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes
Qiao, Ruirui1; Qiao, Hongyu2,3; Zhang, Yan2; Wang, Yabin2; Chi, Chongwei4; Tian, Jie4; Zhang, Lifang1; Cao, Feng2; Gao, Mingyuan1
2017-02-01
发表期刊ACS NANO
卷号11期号:2页码:1816-1825
文章类型Article
摘要Owing to the high mortality rate of cardiovascular diseases, developing novel noninvasive diagnostic methods becomes urgent and mandatory. It is well-known that the rupture of vulnerable plaques directly leads to deadly consequences. However, differentiating vulnerable plaques from stable plaques remains challenging in the clinic. In the current study, osteopontin (OPN), a secreted biomarker associated with macrophages and foamy macrophages, was selected as a target for identifying the vulnerable plaques. A dual modality imaging probe was constructed by covalently attaching an OPN antibody to NaGdF4:Yb,Er@NaGdF4 upconversion nanoparticles. Upon intravenous injection resulting probes, upconversion optical imaging was performed to visualize the plaques induced by altering the shear stress in carotid arteries of a mouse model. The imaging studies revealed that the signals of vulnerable and stable plagues induced by lowered shear stress and oscillatory shear stress, respectively, presented significantly different signal intensities, implying that the current probe and imaging strategy are potentially useful for a precise diagnosis of atherosclerosis plaques.
关键词Vulnerable Plaques Macrophage Opn Molecular Imaging Upconversion Nanoparticle
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1021/acsnano.6b07842
关键词[WOS]SMOOTH-MUSCLE ; SHEAR-STRESS ; IRON-OXIDE ; NANOPARTICLES ; MACROPHAGE ; DISEASE ; MRI ; ATHEROMA ; CELLS
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81571746 ; 81325009 ; 81530057 ; 81530058)
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000395357300075
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被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/14388
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, 28 Fuxing Rd, Beijing 100853, Peoples R China
3.Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China
4.Chinese Acad Sci, Key Lab Mol Imaging, 95 Zhong Guan Cun East Rd, Beijing 100190, Peoples R China
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Qiao, Ruirui,Qiao, Hongyu,Zhang, Yan,et al. Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes[J]. ACS NANO,2017,11(2):1816-1825.
APA Qiao, Ruirui.,Qiao, Hongyu.,Zhang, Yan.,Wang, Yabin.,Chi, Chongwei.,...&Gao, Mingyuan.(2017).Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes.ACS NANO,11(2),1816-1825.
MLA Qiao, Ruirui,et al."Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes".ACS NANO 11.2(2017):1816-1825.
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