CASIA OpenIR  > 中国科学院分子影像重点实验室
Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes
Qiao, Ruirui1; Qiao, Hongyu2,3; Zhang, Yan2; Wang, Yabin2; Chi, Chongwei4; Tian, Jie4; Zhang, Lifang1; Cao, Feng2; Gao, Mingyuan1
Source PublicationACS NANO
2017-02-01
Volume11Issue:2Pages:1816-1825
SubtypeArticle
AbstractOwing to the high mortality rate of cardiovascular diseases, developing novel noninvasive diagnostic methods becomes urgent and mandatory. It is well-known that the rupture of vulnerable plaques directly leads to deadly consequences. However, differentiating vulnerable plaques from stable plaques remains challenging in the clinic. In the current study, osteopontin (OPN), a secreted biomarker associated with macrophages and foamy macrophages, was selected as a target for identifying the vulnerable plaques. A dual modality imaging probe was constructed by covalently attaching an OPN antibody to NaGdF4:Yb,Er@NaGdF4 upconversion nanoparticles. Upon intravenous injection resulting probes, upconversion optical imaging was performed to visualize the plaques induced by altering the shear stress in carotid arteries of a mouse model. The imaging studies revealed that the signals of vulnerable and stable plagues induced by lowered shear stress and oscillatory shear stress, respectively, presented significantly different signal intensities, implying that the current probe and imaging strategy are potentially useful for a precise diagnosis of atherosclerosis plaques.
KeywordVulnerable Plaques Macrophage Opn Molecular Imaging Upconversion Nanoparticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1021/acsnano.6b07842
WOS KeywordSMOOTH-MUSCLE ; SHEAR-STRESS ; IRON-OXIDE ; NANOPARTICLES ; MACROPHAGE ; DISEASE ; MRI ; ATHEROMA ; CELLS
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81571746 ; 81325009 ; 81530057 ; 81530058)
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000395357300075
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/14388
Collection中国科学院分子影像重点实验室
Affiliation1.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, 28 Fuxing Rd, Beijing 100853, Peoples R China
3.Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China
4.Chinese Acad Sci, Key Lab Mol Imaging, 95 Zhong Guan Cun East Rd, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Qiao, Ruirui,Qiao, Hongyu,Zhang, Yan,et al. Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes[J]. ACS NANO,2017,11(2):1816-1825.
APA Qiao, Ruirui.,Qiao, Hongyu.,Zhang, Yan.,Wang, Yabin.,Chi, Chongwei.,...&Gao, Mingyuan.(2017).Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes.ACS NANO,11(2),1816-1825.
MLA Qiao, Ruirui,et al."Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes".ACS NANO 11.2(2017):1816-1825.
Files in This Item: Download All
File Name/Size DocType Version Access License
ACSNano_8.pdf(6308KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Qiao, Ruirui]'s Articles
[Qiao, Hongyu]'s Articles
[Zhang, Yan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Qiao, Ruirui]'s Articles
[Qiao, Hongyu]'s Articles
[Zhang, Yan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Qiao, Ruirui]'s Articles
[Qiao, Hongyu]'s Articles
[Zhang, Yan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: ACSNano_8.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.