Compactly Supported Radial Basis Function-Based Meshless Method for Photon Propagation Model of Fluorescence Molecular Tomography

doi:10.1109/TMI.2016.2601311

	Compactly Supported Radial Basis Function-Based Meshless Method for Photon Propagation Model of Fluorescence Molecular Tomography
	An, Yu 1,2; Liu, Jie1 ; Zhang, Guanglei 1; Jiang, Shixin 1; Ye, Jinzuo2 ; Chi, Chongwei2 ; Tian, Jie 2
发表期刊	IEEE TRANSACTIONS ON MEDICAL IMAGING
	2017-02-01
卷号	36 期号:2 页码:366-373
文章类型	Article
摘要	Fluorescence Molecular Tomography (FMT) is a powerful imaging modality for the research of cancer diagnosis, disease treatment and drug discovery. Via three-dimensional (3-D) imaging reconstruction, it can quantitatively and noninvasively obtain the distribution of fluorescent probes in biological tissues. Currently, photon propagation of FMT is conventionally described by the Finite Element Method (FEM), and it can obtain acceptable image quality. However, there are still some inherent inadequacies in FEM, such as time consuming, discretization error and inflexibility in mesh generation, which partly limit its imaging accuracy. To further improve the solving accuracy of photon propagation model (PPM), we propose a novel compactly supported radial basis functions (CSRBFs)-based meshless method (MM) to implement the PPM of FMT. We introduced a series of independent nodes and continuous CSRBFs to interpolate the PPM, which can avoid complicated mesh generation. To analyze the performance of the proposedMM, we carried out numerical heterogeneous mouse simulation to validate the simulated surface fluorescent measurement. Then we performedan in vivo experiment to observe the tomographic reconstruction. The experimental results confirmed that our proposed MM could obtain more similar surface fluorescence measurement with the golden standard (Monte-Carlo method), and more accurate reconstruction result was achieved via MM in in vivo application.
关键词	Compactly Supported Radial Basis Function Fluorescence Molecular Tomography Meshless Method Photon Propagation Model
WOS标题词	Science & Technology ; Technology ; Life Sciences & Biomedicine
DOI	10.1109/TMI.2016.2601311
关键词[WOS]	L-P REGULARIZATION ; BIOLUMINESCENCE TOMOGRAPHY ; BIOLOGICAL TISSUE ; GALERKIN METHOD ; RECONSTRUCTION ; COLLOCATION ; TECHNOLOGY ; ALGORITHM ; TRANSPORT ; SYSTEM
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(81571836 ; Open Research Project from SKLMCCS(20150103) ; Beijing Natural Science Foundation(7164270) ; Fundamental Research Funds for the Central Universities(2015JBM026) ; China Postdoctoral Science Foundation(2015M570032) ; 81227901 ; 61231004 ; 61501462 ; KKA309004533)
WOS研究方向	Computer Science ; Engineering ; Imaging Science & Photographic Technology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Computer Science, Interdisciplinary Applications ; Engineering, Biomedical ; Engineering, Electrical & Electronic ; Imaging Science & Photographic Technology ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000396115800002
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/14389
专题	中国科学院分子影像重点实验室
作者单位	1.Beijing Jiaotong Univ, Sch Comp & Informat Technol, Dept Biomed Engn, Beijing 100044, Peoples R China 2.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	An, Yu,Liu, Jie,Zhang, Guanglei,et al. Compactly Supported Radial Basis Function-Based Meshless Method for Photon Propagation Model of Fluorescence Molecular Tomography[J]. IEEE TRANSACTIONS ON MEDICAL IMAGING,2017,36(2):366-373.
APA	An, Yu.,Liu, Jie.,Zhang, Guanglei.,Jiang, Shixin.,Ye, Jinzuo.,...&Tian, Jie.(2017).Compactly Supported Radial Basis Function-Based Meshless Method for Photon Propagation Model of Fluorescence Molecular Tomography.IEEE TRANSACTIONS ON MEDICAL IMAGING,36(2),366-373.
MLA	An, Yu,et al."Compactly Supported Radial Basis Function-Based Meshless Method for Photon Propagation Model of Fluorescence Molecular Tomography".IEEE TRANSACTIONS ON MEDICAL IMAGING 36.2(2017):366-373.

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