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Compactly Supported Radial Basis Function-Based Meshless Method for Photon Propagation Model of Fluorescence Molecular Tomography
An, Yu1,2; Liu, Jie1; Zhang, Guanglei1; Jiang, Shixin1; Ye, Jinzuo2; Chi, Chongwei2; Tian, Jie2
Source PublicationIEEE TRANSACTIONS ON MEDICAL IMAGING
2017-02-01
Volume36Issue:2Pages:366-373
SubtypeArticle
AbstractFluorescence Molecular Tomography (FMT) is a powerful imaging modality for the research of cancer diagnosis, disease treatment and drug discovery. Via three-dimensional (3-D) imaging reconstruction, it can quantitatively and noninvasively obtain the distribution of fluorescent probes in biological tissues. Currently, photon propagation of FMT is conventionally described by the Finite Element Method (FEM), and it can obtain acceptable image quality. However, there are still some inherent inadequacies in FEM, such as time consuming, discretization error and inflexibility in mesh generation, which partly limit its imaging accuracy. To further improve the solving accuracy of photon propagation model (PPM), we propose a novel compactly supported radial basis functions (CSRBFs)-based meshless method (MM) to implement the PPM of FMT. We introduced a series of independent nodes and continuous CSRBFs to interpolate the PPM, which can avoid complicated mesh generation. To analyze the performance of the proposedMM, we carried out numerical heterogeneous mouse simulation to validate the simulated surface fluorescent measurement. Then we performedan in vivo experiment to observe the tomographic reconstruction. The experimental results confirmed that our proposed MM could obtain more similar surface fluorescence measurement with the golden standard (Monte-Carlo method), and more accurate reconstruction result was achieved via MM in in vivo application.
KeywordCompactly Supported Radial Basis Function Fluorescence Molecular Tomography Meshless Method Photon Propagation Model
WOS HeadingsScience & Technology ; Technology ; Life Sciences & Biomedicine
DOI10.1109/TMI.2016.2601311
WOS KeywordL-P REGULARIZATION ; BIOLUMINESCENCE TOMOGRAPHY ; BIOLOGICAL TISSUE ; GALERKIN METHOD ; RECONSTRUCTION ; COLLOCATION ; TECHNOLOGY ; ALGORITHM ; TRANSPORT ; SYSTEM
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81571836 ; Open Research Project from SKLMCCS(20150103) ; Beijing Natural Science Foundation(7164270) ; Fundamental Research Funds for the Central Universities(2015JBM026) ; China Postdoctoral Science Foundation(2015M570032) ; 81227901 ; 61231004 ; 61501462 ; KKA309004533)
WOS Research AreaComputer Science ; Engineering ; Imaging Science & Photographic Technology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectComputer Science, Interdisciplinary Applications ; Engineering, Biomedical ; Engineering, Electrical & Electronic ; Imaging Science & Photographic Technology ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000396115800002
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/14389
Collection中国科学院分子影像重点实验室
Affiliation1.Beijing Jiaotong Univ, Sch Comp & Informat Technol, Dept Biomed Engn, Beijing 100044, Peoples R China
2.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
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An, Yu,Liu, Jie,Zhang, Guanglei,et al. Compactly Supported Radial Basis Function-Based Meshless Method for Photon Propagation Model of Fluorescence Molecular Tomography[J]. IEEE TRANSACTIONS ON MEDICAL IMAGING,2017,36(2):366-373.
APA An, Yu.,Liu, Jie.,Zhang, Guanglei.,Jiang, Shixin.,Ye, Jinzuo.,...&Tian, Jie.(2017).Compactly Supported Radial Basis Function-Based Meshless Method for Photon Propagation Model of Fluorescence Molecular Tomography.IEEE TRANSACTIONS ON MEDICAL IMAGING,36(2),366-373.
MLA An, Yu,et al."Compactly Supported Radial Basis Function-Based Meshless Method for Photon Propagation Model of Fluorescence Molecular Tomography".IEEE TRANSACTIONS ON MEDICAL IMAGING 36.2(2017):366-373.
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