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In vivo pentamodal tomographic imaging for small animals
Liu, Muhan1,2,3; Guo, Hongbo3,4; Liu, Hongbo1,2,3; Zhang, Zeyu3; Chi, Chongwei3; Hui, Hui3; Dong, Di3; Hu, Zhenhua3,5; Tian, Jie1,2,3,5
Source PublicationBIOMEDICAL OPTICS EXPRESS
2017-03-01
Volume8Issue:3Pages:1356-1371
SubtypeArticle
AbstractMultimodality molecular imaging emerges as a powerful strategy for correlating multimodal information. We developed a pentamodal imaging system which can perform positron emission tomography, bioluminescence tomography, fluorescence molecular tomography, Cerenkov luminescence tomography and X-ray computed tomography successively. Performance of sub-systems corresponding to different modalities were characterized. In vivo multimodal imaging of an orthotopic hepatocellular carcinoma xenograft mouse model was performed, and acquired multimodal images were fused. The feasibility of pentamodal tomographic imaging system was successfully validated with the imaging application on the mouse model. The ability of integrating anatomical, metabolic, and pharmacokinetic information promises applications of multimodality molecular imaging in precise medicine. (C) 2017 Optical Society of America.
KeywordPentamodal Tomographic Imaging
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1364/BOE.8.001356
WOS KeywordBIOLUMINESCENCE TOMOGRAPHY ; CLINICAL-APPLICATIONS ; MRI ; DEVICES ; SYSTEM ; RECONSTRUCTION ; MODALITIES ; ALGORITHM ; SPECT/CT ; PLATFORM
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China (NSFC)(81227901 ; National Key Research and Development Program of China(2016YFC0102600) ; 81527805 ; 61231004 ; 61622117 ; 81671759)
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000395942600007
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/14427
Collection中国科学院分子影像重点实验室
Affiliation1.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian 710071, Shaanxi, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Northwest Univ Xian, Sch Informat Sci & Technol, Xian 710069, Peoples R China
5.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Liu, Muhan,Guo, Hongbo,Liu, Hongbo,et al. In vivo pentamodal tomographic imaging for small animals[J]. BIOMEDICAL OPTICS EXPRESS,2017,8(3):1356-1371.
APA Liu, Muhan.,Guo, Hongbo.,Liu, Hongbo.,Zhang, Zeyu.,Chi, Chongwei.,...&Tian, Jie.(2017).In vivo pentamodal tomographic imaging for small animals.BIOMEDICAL OPTICS EXPRESS,8(3),1356-1371.
MLA Liu, Muhan,et al."In vivo pentamodal tomographic imaging for small animals".BIOMEDICAL OPTICS EXPRESS 8.3(2017):1356-1371.
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