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Visual deprivation selectively reshapes the intrinsic functional architecture of the anterior insula subregions
Liu, Lihua1,2; Yuan, Congcong1; Ding, Hao3; Xu, Yongjie1; Long, Miaomiao1,2; Li, YanJun1; Liu, Yong4,5,6,7; Jiang, Tianzi4,5,6,8,9; Qin, Wen1; Shen, Wen; Yu, Chunshui1
Source PublicationSCIENTIFIC REPORTS
2017-03-30
Volume7
SubtypeArticle
AbstractThe anterior insula (AI) is the core hub of salience network that serves to identify the most relevant stimuli among vast sensory inputs and forward them to higher cognitive regions to guide behaviour. As blind subjects were usually reported with changed perceptive abilities for salient non-visual stimuli, we hypothesized that the resting-state functional network of the AI is selectively reorganized after visual deprivation. The resting-state functional connectivity (FC) of the bilateral dorsal and ventral AI was calculated for twenty congenitally blind (CB), 27 early blind (EB), 44 late blind (LB) individuals and 50 sighted controls (SCs). The FCs of the dorsal AI were strengthened with the dorsal visual stream, while weakened with the ventral visual stream in the blind than the SCs; in contrast, the FCs of the ventral AI of the blind was strengthened with the ventral visual stream. Furthermore, these strengthened FCs of both the dorsal and ventral AI were partially negatively associated with the onset age of blindness. Our result indicates two parallel pathways that selectively transfer non-visual salient information between the deprived "visual" cortex and salience network in blind subjects.
WOS HeadingsScience & Technology
DOI10.1038/srep45675
WOS KeywordCROSS-MODAL PLASTICITY ; CONGENITALLY BLIND INDIVIDUALS ; LATERAL OCCIPITAL COMPLEX ; SIGHTED INDIVIDUALS ; CORTICAL ACTIVITY ; WORKING-MEMORY ; AUDITORY ABILITIES ; EARLY DEAFNESS ; WHITE-MATTER ; EARLY-ONSET
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81401394 ; 81425013)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000398955900001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15076
Collection脑网络组研究中心
Affiliation1.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China
2.Tianjin First Cent Hosp, Dept Radiol, Tianjin 300192, Peoples R China
3.Tianjin Med Univ, Sch Med Imaging, Tianjin 300070, Peoples R China
4.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
6.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
8.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 625014, Peoples R China
9.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
Recommended Citation
GB/T 7714
Liu, Lihua,Yuan, Congcong,Ding, Hao,et al. Visual deprivation selectively reshapes the intrinsic functional architecture of the anterior insula subregions[J]. SCIENTIFIC REPORTS,2017,7.
APA Liu, Lihua.,Yuan, Congcong.,Ding, Hao.,Xu, Yongjie.,Long, Miaomiao.,...&Yu, Chunshui.(2017).Visual deprivation selectively reshapes the intrinsic functional architecture of the anterior insula subregions.SCIENTIFIC REPORTS,7.
MLA Liu, Lihua,et al."Visual deprivation selectively reshapes the intrinsic functional architecture of the anterior insula subregions".SCIENTIFIC REPORTS 7(2017).
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