CASIA OpenIR  > 中国科学院分子影像重点实验室
Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma
Li, Gang1; Chi, Chong-wei2; Shao, Xian-Fang1; Fang, Chi-Hua3
2017-05-20
发表期刊BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷号487期号:1页码:122-127
文章类型Article
摘要The aim of this study was to evaluate the inhibiting effect of apigenin on liver cancer in vivo based on the optical molecular imaging method. Subcutaneous liver tumor models were established using respective 1 x 10(6) firefly luciferase (fLuc) and green fluorescent protein (GFP) labeled human hepatocellular carcinoma cells (HepG2-fLuc and HepG2-GFP cells) in 20 BALB/c nude mice which were randomly divided into two groups, 10 in each group. After the tumor cells were implanted 15 days, apigenin was administered through intraperitoneal injection in group B, the other ten mice as control group A. Bioluminescence imaging (BLI) and fluorescence molecular imaging (FMI) were carried out for the follow-up of subcutaneous tumor model. As time goes on, intensity and distribution of bioluminescence and fluorescence of tumours increased gradually with the growth of tumours little by little. The whole process of observation was in accordance with known activities of HCC in the human liver. The tumor volume and tumor weight were significant lower in group B than in group A (p < 0.05), Subcutaneous tumours in the apigenin treatment group B based on BLI and FMI were significantly inhibited compared to the control group A (p < 0.05). Apigenin could be expected as a new drug to treat hepatocellular carcinoma. Optical molecular imaging technology enabled the non-invasive and reliable assessment of anti-tumor drug efficacy on liver cancer. (C) 2017 Elsevier Inc. All rights reserved.
关键词Apigenin Molecular Imaging Hepatocellular Carcinoma
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.bbrc.2017.04.029
关键词[WOS]TUMOR ; CANCER ; MICE ; TOMOGRAPHY ; MOUSE ; CELLS ; MODEL
收录类别SCI
语种英语
项目资助者National Basic Research Program of China (973 Program)(2011CB707700) ; National Natural Science Foundation of China(81027002 ; Chinese Academy of Sciences Visiting Professorship for Senior International Scientists(2012T1G0036) ; National High Technology Research and Development Program of China (863 Program)(2006AA02Z346 ; Chinese Medicine Foundation of Hunan Province, China(20171) ; Guangdong Province(2010A090100032) ; Chinese Academy of Sciences(2010A090100032) ; Science and Technology Project of Guangdong Province, China(200304303 ; Industrial Technology Research and Development Program of Guangdong Province(2012A030400013) ; 81170458) ; 2012AA021105) ; 2011t1031800088 ; 2011B031800091)
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
WOS类目Biochemistry & Molecular Biology ; Biophysics
WOS记录号WOS:000400954300019
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/15098
专题中国科学院分子影像重点实验室
作者单位1.Hunan Univ Chinese Med, Changde Tradit Chinese Med Hosp 1, Changsha 410208, Hunan, Peoples R China
2.Chinese Acad Sci, Key Lab Mol Imaging, Beijing, Peoples R China
3.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Li, Gang,Chi, Chong-wei,Shao, Xian-Fang,et al. Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017,487(1):122-127.
APA Li, Gang,Chi, Chong-wei,Shao, Xian-Fang,&Fang, Chi-Hua.(2017).Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,487(1),122-127.
MLA Li, Gang,et al."Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 487.1(2017):122-127.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
1-s2.0-S0006291X1730(1261KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Gang]的文章
[Chi, Chong-wei]的文章
[Shao, Xian-Fang]的文章
百度学术
百度学术中相似的文章
[Li, Gang]的文章
[Chi, Chong-wei]的文章
[Shao, Xian-Fang]的文章
必应学术
必应学术中相似的文章
[Li, Gang]的文章
[Chi, Chong-wei]的文章
[Shao, Xian-Fang]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 1-s2.0-S0006291X1730685X-main.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。