Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes

doi:10.1039/c6cs00675b

	Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes
	Xia, Yuqiong 1; Zhang, Ruili 1; Wang, Zhongliang 1; Tian, Jie 1,2; Chen, Xiaoyuan 3
发表期刊	CHEMICAL SOCIETY REVIEWS
	2017-05-21
卷号	46 期号:10 页码:2824-2843
文章类型	Review
摘要	RNA plays an important role in life processes. Imaging of messenger RNAs (mRNAs) and micro-RNAs (miRNAs) not only allows us to learn the formation and transcription of mRNAs and the biogenesis of miRNAs involved in various life processes, but also helps in detecting cancer. High-performance RNA imaging probes greatly expand our view of life processes and enhance the cancer detection accuracy. In this review, we summarize the state-of-the-art high-performance RNA imaging probes, including exogenous probes that can image RNA sequences with special modification and endogeneous probes that can directly image endogenous RNAs without special treatment. For each probe, we review its structure and imaging principle in detail. Finally, we summarize the application of mRNA and miRNA imaging probes in studying life processes as well as in detecting cancer. By correlating the structures and principles of various probes with their practical uses, we compare different RNA imaging probes and offer guidance for better utilization of the current imaging probes and the future design of higher-performance RNA imaging probes.
WOS标题词	Science & Technology ; Physical Sciences
DOI	10.1039/c6cs00675b
关键词[WOS]	IN-SITU HYBRIDIZATION ; ENHANCED-RAMAN-SPECTROSCOPY ; ROLLING CIRCLE AMPLIFICATION ; MULTIPLE MESSENGER-RNAS ; LIVING BACTERIAL-CELLS ; DNA MOLECULAR BEACONS ; LIVE CELLS ; GENE-EXPRESSION ; GOLD NANOPARTICLES ; MICRORNA BIOGENESIS
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(81671753 ; national 1000 Young Talents Program of China ; Fundamental Research Funds for the Central universities(JB161202) ; Intramural Research Program, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) ; 81501524)
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000401905400008
引用统计	被引频次：107[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/15114
专题	中国科学院分子影像重点实验室
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol Imaging & Neuroimaging, Minist Educ, Xian 710126, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 3.NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA
推荐引用方式 GB/T 7714	Xia, Yuqiong,Zhang, Ruili,Wang, Zhongliang,et al. Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes[J]. CHEMICAL SOCIETY REVIEWS,2017,46(10):2824-2843.
APA	Xia, Yuqiong,Zhang, Ruili,Wang, Zhongliang,Tian, Jie,&Chen, Xiaoyuan.(2017).Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes.CHEMICAL SOCIETY REVIEWS,46(10),2824-2843.
MLA	Xia, Yuqiong,et al."Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes".CHEMICAL SOCIETY REVIEWS 46.10(2017):2824-2843.