Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| Weight Multispectral Reconstruction Strategy for Enhanced Reconstruction Accuracy and Stability With Cerenkov Luminescence Tomography | |
Guo, Hongbo1,2; He, Xiaowei1; Liu, Muhan2,3,4; Zhang, Zeyu2,5 ; Hu, Zhenhua2,5,6; Tian, Jie2,5,6
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| 发表期刊 | IEEE TRANSACTIONS ON MEDICAL IMAGING
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| 2017-06-01 | |
| 卷号 | 36期号:6页码:1337-1346 |
| 文章类型 | Article |
| 摘要 | Cerenkov luminescence tomography (CLT) provides a novel technique for 3-D noninvasive detection of radiopharmaceuticals in living subjects. However, because of the severe scattering of Cerenkov light, the reconstruction accuracy and stability of CLT is still unsatisfied. In this paper, a modified weight multispectral CLT (wmCLT) reconstruction strategy was developed which split the Cerenkov radiation spectrum into several sub-spectral bands and weighted the sub-spectral results to obtain the final result. To better evaluate the property of the wmCLT reconstruction strategy in terms of accuracy, stability and practicability, several numerical simulation experiments and in vivo experiments were conducted and the results obtained were compared with the traditional multispectral CLT (mCLT) and hybrid-spectral CLT (hCLT) reconstruction strategies. The numerical simulation results indicated that wmCLT strategy significantly improved the accuracy of Cerenkov source localization and intensity quantitation and exhibited good stability in suppressing noise in numerical simulation experiments. And the comparison of the results achieved from different in vivo experiments further indicated significant improvement of the wmCLT strategy in terms of the shape recovery of the bladder and the spatial resolution of imaging xenograft tumors. Overall the strategy reported here will facilitate the development of nuclear and optical molecular tomography in theoretical study. |
| 关键词 | Cerenkov Luminescence Tomography Weight Multispectral Reconstruction Inverse Problem |
| WOS标题词 | Science & Technology ; Technology ; Life Sciences & Biomedicine |
| DOI | 10.1109/TMI.2017.2658661 |
| 关键词[WOS] | CONJUGATE-GRADIENT METHOD ; BIOLUMINESCENCE TOMOGRAPHY ; SPARSE RECONSTRUCTION ; CANCER ; PET |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | National Natural Science Foundation of China(81227901 ; National Key Research and Development Program of China(2016YFC0102600) ; 61372046 ; 81527805 ; 61231004 ; 61622117 ; 11571012 ; 81671759 ; 61302024) |
| WOS研究方向 | Computer Science ; Engineering ; Imaging Science & Photographic Technology ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Computer Science, Interdisciplinary Applications ; Engineering, Biomedical ; Engineering, Electrical & Electronic ; Imaging Science & Photographic Technology ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS记录号 | WOS:000402722500012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/15123 |
| 专题 | 中国科学院分子影像重点实验室 |
| 作者单位 | 1.Northwest Univ, Sch Informat Sci & Technol, Xian 710069, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Xidian Univ, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Peoples R China 4.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China 5.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 6.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China |
| 第一作者单位 | 中国科学院自动化研究所 |
| 推荐引用方式 GB/T 7714 | Guo, Hongbo,He, Xiaowei,Liu, Muhan,et al. Weight Multispectral Reconstruction Strategy for Enhanced Reconstruction Accuracy and Stability With Cerenkov Luminescence Tomography[J]. IEEE TRANSACTIONS ON MEDICAL IMAGING,2017,36(6):1337-1346. |
| APA | Guo, Hongbo,He, Xiaowei,Liu, Muhan,Zhang, Zeyu,Hu, Zhenhua,&Tian, Jie.(2017).Weight Multispectral Reconstruction Strategy for Enhanced Reconstruction Accuracy and Stability With Cerenkov Luminescence Tomography.IEEE TRANSACTIONS ON MEDICAL IMAGING,36(6),1337-1346. |
| MLA | Guo, Hongbo,et al."Weight Multispectral Reconstruction Strategy for Enhanced Reconstruction Accuracy and Stability With Cerenkov Luminescence Tomography".IEEE TRANSACTIONS ON MEDICAL IMAGING 36.6(2017):1337-1346. |
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