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Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor
Shen, Song1; Ding, Bei1; Zhang, Shengchang1; Qi, Xueyong1; Wang, Kun4; Tian, Jie4; Yan, Yongsheng3; Ge, Yanru1; Wu, Lin2
Source PublicationNANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
2017-07-01
Volume13Issue:5Pages:1607-1616
SubtypeArticle
AbstractThermosensitive yolk-shell nanoparticles were developed as remote-controlled targeting drug delivery platform for multimodal imaging and combined therapy of cancer. The nanoparticles were fabricated using magnetic Fe3O4 nanoparticles as photothermal cores, thermo-responsive poly(N-isopropylacrylamide)-co-1-Vinyl-2-pyrrolidone p(NIPAM-co-NVP) as shells (Fe3O4-PNIPAM), with a hollow space between the two layers for loading of chemotherapeutic drug. The magnetic iron oxide nanoparticle cores could absorb and transform light to heat efficiently upon the irradiation of near infrared (NIR) laser, resulting in the shrink of the PNIPAM shell and the release of chemo-drugs. In vivo fluorescence/photoacoustic images demonstrated that Fe3O4-PNIPAM nanoparticles could accumulate in the tumor after intravenous injection. Upon the irradiation of the NIR laser, DOX-Fe3O4-PNIPAM nanoparticles exhibited outstanding synergistic effect. The tumor inhibition rate increased from 40.3% (DOX-Fe3O4-PNIPAM alone) and 65.2% (Fe3O4-PNIPAM +NIR) to 91.5%. The results demonstrated that the NIR-responsive nanocarrier offers a novel strategy for cancer theranostics and combined therapy of cancer. (C) 2017 Elsevier Inc. All rights reserved.
KeywordPhotoacoustic Imaging Magnetic Iron Oxide Thermoresponsive Photothermal Therapy Targeting Drug Delivery
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.nano.2017.02.014
WOS KeywordIRON-OXIDE NANOPARTICLES ; DRUG-DELIVERY ; MAGNETIC NANOPARTICLES ; CARBON NANOTUBES ; CANCER-THERAPY ; LOW TOXICITY ; CHEMOTHERAPY ; HYPERTHERMIA ; GRAPHENE ; NANORODS
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81172999 ; Natural Science Foundation of Jiangsu Province(BK20150534) ; Senior Talent Foundation of Jiangsu University(14JDG181) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; China Postdoctoral Science Foundation(2015 M580404) ; Jiangsu Planned Projects for Postdoctoral Research Funds(1402075B) ; 81503017)
WOS Research AreaScience & Technology - Other Topics ; Research & Experimental Medicine
WOS SubjectNanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS IDWOS:000403662500003
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15129
Collection中国科学院分子影像重点实验室
Affiliation1.Jiangsu Univ, Sch Pharm, Dept Pharmaceut, Zhenjiang, Peoples R China
2.Jiangsu Univ, Dept Clin Pharm, Affiliated Hosp, Zhenjiang, Peoples R China
3.Jiangsu Univ, Inst Green Chem & Chem Technol, Zhenjiang, Peoples R China
4.Chinese Acad Sci, Inst Automat, Intelligent Med Res Ctr, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Shen, Song,Ding, Bei,Zhang, Shengchang,et al. Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2017,13(5):1607-1616.
APA Shen, Song.,Ding, Bei.,Zhang, Shengchang.,Qi, Xueyong.,Wang, Kun.,...&Wu, Lin.(2017).Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,13(5),1607-1616.
MLA Shen, Song,et al."Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 13.5(2017):1607-1616.
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