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Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor
Shen, Song1; Ding, Bei1; Zhang, Shengchang1; Qi, Xueyong1; Wang, Kun4; Tian, Jie4; Yan, Yongsheng3; Ge, Yanru1; Wu, Lin2
2017-07-01
发表期刊NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷号13期号:5页码:1607-1616
文章类型Article
摘要Thermosensitive yolk-shell nanoparticles were developed as remote-controlled targeting drug delivery platform for multimodal imaging and combined therapy of cancer. The nanoparticles were fabricated using magnetic Fe3O4 nanoparticles as photothermal cores, thermo-responsive poly(N-isopropylacrylamide)-co-1-Vinyl-2-pyrrolidone p(NIPAM-co-NVP) as shells (Fe3O4-PNIPAM), with a hollow space between the two layers for loading of chemotherapeutic drug. The magnetic iron oxide nanoparticle cores could absorb and transform light to heat efficiently upon the irradiation of near infrared (NIR) laser, resulting in the shrink of the PNIPAM shell and the release of chemo-drugs. In vivo fluorescence/photoacoustic images demonstrated that Fe3O4-PNIPAM nanoparticles could accumulate in the tumor after intravenous injection. Upon the irradiation of the NIR laser, DOX-Fe3O4-PNIPAM nanoparticles exhibited outstanding synergistic effect. The tumor inhibition rate increased from 40.3% (DOX-Fe3O4-PNIPAM alone) and 65.2% (Fe3O4-PNIPAM +NIR) to 91.5%. The results demonstrated that the NIR-responsive nanocarrier offers a novel strategy for cancer theranostics and combined therapy of cancer. (C) 2017 Elsevier Inc. All rights reserved.
关键词Photoacoustic Imaging Magnetic Iron Oxide Thermoresponsive Photothermal Therapy Targeting Drug Delivery
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.nano.2017.02.014
关键词[WOS]IRON-OXIDE NANOPARTICLES ; DRUG-DELIVERY ; MAGNETIC NANOPARTICLES ; CARBON NANOTUBES ; CANCER-THERAPY ; LOW TOXICITY ; CHEMOTHERAPY ; HYPERTHERMIA ; GRAPHENE ; NANORODS
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81172999 ; Natural Science Foundation of Jiangsu Province(BK20150534) ; Senior Talent Foundation of Jiangsu University(14JDG181) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; China Postdoctoral Science Foundation(2015 M580404) ; Jiangsu Planned Projects for Postdoctoral Research Funds(1402075B) ; 81503017)
WOS研究方向Science & Technology - Other Topics ; Research & Experimental Medicine
WOS类目Nanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS记录号WOS:000403662500003
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/15129
专题中国科学院分子影像重点实验室
作者单位1.Jiangsu Univ, Sch Pharm, Dept Pharmaceut, Zhenjiang, Peoples R China
2.Jiangsu Univ, Dept Clin Pharm, Affiliated Hosp, Zhenjiang, Peoples R China
3.Jiangsu Univ, Inst Green Chem & Chem Technol, Zhenjiang, Peoples R China
4.Chinese Acad Sci, Inst Automat, Intelligent Med Res Ctr, Beijing, Peoples R China
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GB/T 7714
Shen, Song,Ding, Bei,Zhang, Shengchang,et al. Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2017,13(5):1607-1616.
APA Shen, Song.,Ding, Bei.,Zhang, Shengchang.,Qi, Xueyong.,Wang, Kun.,...&Wu, Lin.(2017).Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,13(5),1607-1616.
MLA Shen, Song,et al."Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 13.5(2017):1607-1616.
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