Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor

doi:10.1016/j.nano.2017.02.014

	Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor
	Shen, Song 1; Ding, Bei 1; Zhang, Shengchang 1; Qi, Xueyong 1; Wang, Kun4 ; Tian, Jie 4; Yan, Yongsheng 3; Ge, Yanru 1; Wu, Lin 2
发表期刊	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
	2017-07-01
卷号	13 期号:5 页码:1607-1616
文章类型	Article
摘要	Thermosensitive yolk-shell nanoparticles were developed as remote-controlled targeting drug delivery platform for multimodal imaging and combined therapy of cancer. The nanoparticles were fabricated using magnetic Fe3O4 nanoparticles as photothermal cores, thermo-responsive poly(N-isopropylacrylamide)-co-1-Vinyl-2-pyrrolidone p(NIPAM-co-NVP) as shells (Fe3O4-PNIPAM), with a hollow space between the two layers for loading of chemotherapeutic drug. The magnetic iron oxide nanoparticle cores could absorb and transform light to heat efficiently upon the irradiation of near infrared (NIR) laser, resulting in the shrink of the PNIPAM shell and the release of chemo-drugs. In vivo fluorescence/photoacoustic images demonstrated that Fe3O4-PNIPAM nanoparticles could accumulate in the tumor after intravenous injection. Upon the irradiation of the NIR laser, DOX-Fe3O4-PNIPAM nanoparticles exhibited outstanding synergistic effect. The tumor inhibition rate increased from 40.3% (DOX-Fe3O4-PNIPAM alone) and 65.2% (Fe3O4-PNIPAM +NIR) to 91.5%. The results demonstrated that the NIR-responsive nanocarrier offers a novel strategy for cancer theranostics and combined therapy of cancer. (C) 2017 Elsevier Inc. All rights reserved.
关键词	Photoacoustic Imaging Magnetic Iron Oxide Thermoresponsive Photothermal Therapy Targeting Drug Delivery
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1016/j.nano.2017.02.014
关键词[WOS]	IRON-OXIDE NANOPARTICLES ; DRUG-DELIVERY ; MAGNETIC NANOPARTICLES ; CARBON NANOTUBES ; CANCER-THERAPY ; LOW TOXICITY ; CHEMOTHERAPY ; HYPERTHERMIA ; GRAPHENE ; NANORODS
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(81172999 ; Natural Science Foundation of Jiangsu Province(BK20150534) ; Senior Talent Foundation of Jiangsu University(14JDG181) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; China Postdoctoral Science Foundation(2015 M580404) ; Jiangsu Planned Projects for Postdoctoral Research Funds(1402075B) ; 81503017)
WOS研究方向	Science & Technology - Other Topics ; Research & Experimental Medicine
WOS类目	Nanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS记录号	WOS:000403662500003
引用统计	被引频次：51[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/15129
专题	中国科学院分子影像重点实验室
作者单位	1.Jiangsu Univ, Sch Pharm, Dept Pharmaceut, Zhenjiang, Peoples R China 2.Jiangsu Univ, Dept Clin Pharm, Affiliated Hosp, Zhenjiang, Peoples R China 3.Jiangsu Univ, Inst Green Chem & Chem Technol, Zhenjiang, Peoples R China 4.Chinese Acad Sci, Inst Automat, Intelligent Med Res Ctr, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Shen, Song,Ding, Bei,Zhang, Shengchang,et al. Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2017,13(5):1607-1616.
APA	Shen, Song.,Ding, Bei.,Zhang, Shengchang.,Qi, Xueyong.,Wang, Kun.,...&Wu, Lin.(2017).Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,13(5),1607-1616.
MLA	Shen, Song,et al."Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 13.5(2017):1607-1616.

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