Neural correlates of 12-h abstinence-induced craving in young adult smokers: a resting-state study

doi:10.1007/s11682-016-9544-3

	Neural correlates of 12-h abstinence-induced craving in young adult smokers: a resting-state study
	Li, Yangding 1,2; Yuan, Kai 1,2; Bi, Yanzhi 1,2; Guan, Yanyan 1,2; Cheng, Jiadong 1,2; Zhang, Yajuan 1,2; Shi, Sha 1,2; Lu, Xiaoqi 3; Yu, Dahua 3; Tian, Jie 1,2,4
发表期刊	BRAIN IMAGING AND BEHAVIOR
	2017-06-01
卷号	11 期号:3 页码:677-684
文章类型	Article
摘要	Studying the neural correlates of craving to smoke in young adulthood is of great importance to improve treatment outcomes in nicotine dependence. Previous nicotine dependence studies mainly focused on the neural substrates of craving elicited by smoking-related cues. More explicit attention to abstinence-induced craving during resting state in nicotine dependence has the potential to yield valuable information about craving, and characterizing this kind of craving is critical for developing effective interventions. Twenty-five young male smokers were enrolled in the present study. A within-subject experiment design was carried out to compare regional homogeneity (ReHo) between 12-h smoking abstinence and smoking satiety conditions during resting state in young adult smokers. Then, the ReHo changes associated with smoking abstinence (compared with satiety) were further examined for correlations with abstinence-induced changes in subjective craving. We found young adult smokers in abstinence state (compared with satiety) had higher ReHo in brain regions in fronto-striatal circuits including bilateral caudate, anterior cingulate cortex (ACC) and bilateral dorsal lateral prefrontal cortex (DLPFC), as well as brain regions in default mode network (DMN) including posterior cingulate cortex (PCC)/precuneus and angular gyrus. Additionally, we found the ReHo changes of the ACC and the bilateral caudate were positively correlated with the changes in craving induced by abstinence (i.e., abstinence minus satiety) in young adult smokers. The present findings improve the understanding of the effects of acute smoking abstinence on spontaneous brain activity and may contribute new insights into the neural mechanism of abstinence-induced craving in nicotine dependence.
关键词	Resting State Within-subject Design Regional Homogeneity (Reho) Abstinence-induced Craving Young Adult Smokers
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1007/s11682-016-9544-3
关键词[WOS]	TRANSCRANIAL MAGNETIC STIMULATION ; NICOTINIC ACETYLCHOLINE-RECEPTORS ; REGIONAL HOMOGENEITY CHANGES ; GRAY-MATTER VOLUMES ; CIGARETTE-SMOKING ; FUNCTIONAL CONNECTIVITY ; ALZHEIMERS-DISEASE ; COGNITIVE CONTROL ; DORSAL STRIATUM ; DEFAULT MODE
收录类别	SCI ; SSCI
语种	英语
项目资助者	National Natural Science Foundation of China(81571751 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ4118) ; Fundamental Research Funds for the Central Universities(JB151204 ; Natural Science Foundation of Inner Mongolia(2014BS0610) ; Innovation Fund Project of Inner Mongolia University of Science and Technology(2015QNGG03 ; China Post-doctoral Science Foundation(2014M552416) ; 81571753 ; JB121405) ; 2014QDL002) ; 61502376 ; 81401478 ; 81401488 ; 81470816 ; 81471737 ; 81301281 ; 81271546 ; 81271549)
WOS研究方向	Neurosciences & Neurology
WOS类目	Neuroimaging
WOS记录号	WOS:000403676400007
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/15232
专题	中国科学院分子影像重点实验室
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China 2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Peoples R China 3.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Inner Mongolia Key Lab Pattern Recognit & Intelli, Baotou 014010, Inner Mongolia, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Yangding,Yuan, Kai,Bi, Yanzhi,et al. Neural correlates of 12-h abstinence-induced craving in young adult smokers: a resting-state study[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(3):677-684.
APA	Li, Yangding.,Yuan, Kai.,Bi, Yanzhi.,Guan, Yanyan.,Cheng, Jiadong.,...&Tian, Jie.(2017).Neural correlates of 12-h abstinence-induced craving in young adult smokers: a resting-state study.BRAIN IMAGING AND BEHAVIOR,11(3),677-684.
MLA	Li, Yangding,et al."Neural correlates of 12-h abstinence-induced craving in young adult smokers: a resting-state study".BRAIN IMAGING AND BEHAVIOR 11.3(2017):677-684.