From Detection to Resection: Photoacoustic Tomography and Surgery Guidance with Au@liposome-ICG Nanoparticles in Liver Cancer

	From Detection to Resection: Photoacoustic Tomography and Surgery Guidance with Au@liposome-ICG Nanoparticles in Liver Cancer
	Tianpei Guan 1,2,3,4; Wenting Shang2,3 ; Hui Li 2,3; Xin Yang2,3 ; Chihua Fang 1; Jie Tian 2,3; Kun Wang2,3
发表期刊	Bioconjugate Chemistry
	2017
卷号	4 期号:28 页码:1221-1228
摘要	Conventional imaging methods encounter challenges in diagnosing liver cancer that is less than 10 mm and/or without typical hypervascular features. With deep penetration and high spatial resolution imaging capability, the emerging photoacoustic tomography may offer better diagnostic efficacy for non-invasive liver cancer detection. Moreover, near-infrared fluorescence imaging guided hepatectomy was proven to be able to identify nodules at millimeter level. Thus, suitable photoacoustic and fluorescence dual-modality imaging probe may benefit patients in early diagnosis and complete resection. In this study, we fabricated indocyanine green loaded gold nanorod@liposome core-shell nanoparticles (Au@liposome-ICG) to integrate both imaging strategies. These nanoparticles exhibit superior biocompatibility, high stability, and enhanced dual-model imaging signal. Then, we explored its effectiveness of tumor detection and surgery guidance in orthotopic liver cancer mouse models. Histological analysis confirmed the accuracy of the probe in liver cancer detection and resection. This novel dual-modality nano-probe holds promise for early diagnosis and better surgical outcome of liver cancer and has great potential for clinical translation.
关键词	Photoacoustic Tomography Fluorescence Imaging Au Nanorods Liver Cancer Tumor Detection Surgery Guidance
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/15425
专题	中国科学院分子影像重点实验室
作者单位	1.Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical 2.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese 3.Beijing Key Laboratory of Molecular Imaging, Beijing 100190, China. 4.Guangdong provincial clinical and engineering center of digital medicine,
推荐引用方式 GB/T 7714	Tianpei Guan,Wenting Shang,Hui Li,et al. From Detection to Resection: Photoacoustic Tomography and Surgery Guidance with Au@liposome-ICG Nanoparticles in Liver Cancer[J]. Bioconjugate Chemistry,2017,4(28):1221-1228.
APA	Tianpei Guan.,Wenting Shang.,Hui Li.,Xin Yang.,Chihua Fang.,...&Kun Wang.(2017).From Detection to Resection: Photoacoustic Tomography and Surgery Guidance with Au@liposome-ICG Nanoparticles in Liver Cancer.Bioconjugate Chemistry,4(28),1221-1228.
MLA	Tianpei Guan,et al."From Detection to Resection: Photoacoustic Tomography and Surgery Guidance with Au@liposome-ICG Nanoparticles in Liver Cancer".Bioconjugate Chemistry 4.28(2017):1221-1228.

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