CASIA OpenIR  > 中国科学院分子影像重点实验室
High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy
Wei, Qiaolin1,2; Chen, Yao1; Ma, Xibo3; Ji, Jianfeng1; Qiao, Yue1,2; Zhou, Bo1,2; Ma, Fei2; Ling, Daishun4; Zhang, Hong1; Tian, Mei1; Tian, Jie3; Zhou, Min1,2,5,6
2018-01-10
发表期刊ADVANCED FUNCTIONAL MATERIALS
卷号28期号:2页码:1704634
文章类型Article
摘要Renal-clearable nanoparticles have made it possible to overcome the toxicity by nonspecific accumulation in healthy tissues/ organs due to their highly efficient clearance characteristics. However, their tumor uptake is relatively low due to the short blood circulation time and rapid body elimination. Here, this problem is addressed by developing renal-clearable nanoparticles by controlled coating of sub-6 nm CuS nanodots (CuSNDs) on doxorubicin ladened mesoporous silica nanoparticles (pore size approximate to 6 nm) for multimodal application. High tumor uptake of the as-synthesized nanoparticles (abbreviated as MDNs) is achieved due to the longer blood circulation time. The MDNs also show excellent performance in bimodal imaging. Moreover, the MDNs demonstrated a photothermally sensitive drug release and pronounced synergetic effects of chemo-photothermal therapy, which were confirmed by two different tumor models in vivo. A novel key feature of the proposed synthesis is the use of renal-clearable CuSNDs and biodegradable mesoporous silica nanoparticles which also are renal-clearable after degradation. Therefore, the MDNs would be rapidly degraded and excreted in a reasonable period in living body and avoid long-term toxicity. Such biodegradable and clearable single-compartment theranostic agents applicable in highly integrated multimodal imaging and multiple therapeutic functions may have substantial potentials in clinical practice.
关键词Biodegradation Multimodal Imaging Nanoplatforms Renal Clearance Theranostics
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1002/adfm.201704634
关键词[WOS]MESOPOROUS SILICA NANOPARTICLES ; CONTRAST AGENTS ; RENAL CLEARANCE ; DRUG-DELIVERY ; QUANTUM DOTS ; BIODISTRIBUTION ; TISSUE
收录类别SCI
语种英语
项目资助者National Key Research and Development Program of China(2016YFA0100900) ; National Key Basic Research Program of the China(2014CB744504) ; National Natural Science Foundation of China(81671748) ; Project of Chinese Thousand Youth Talents
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000419454000013
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/19555
专题中国科学院分子影像重点实验室
作者单位1.Zhejiang Univ, Affiliated Hosp 2, Sch Med, PET Ctr,Dept Nucl Med, Hangzhou 310009, Zhejiang, Peoples R China
2.Zhejiang Univ, Inst Translat Med, Hangzhou 310009, Zhejiang, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310009, Zhejiang, Peoples R China
5.Zhejiang Univ, Minist Educ, Key Lab Early Warning & Intervent Malignant Tumor, Hangzhou 310009, Zhejiang, Peoples R China
6.Zhejiang Univ, State Key Lab Modern Opt Instrumentat, Hangzhou 310058, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714
Wei, Qiaolin,Chen, Yao,Ma, Xibo,et al. High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(2):1704634.
APA Wei, Qiaolin.,Chen, Yao.,Ma, Xibo.,Ji, Jianfeng.,Qiao, Yue.,...&Zhou, Min.(2018).High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy.ADVANCED FUNCTIONAL MATERIALS,28(2),1704634.
MLA Wei, Qiaolin,et al."High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Image-Guided Cancer Therapy".ADVANCED FUNCTIONAL MATERIALS 28.2(2018):1704634.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
10.1002@adfm.2017046(6497KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wei, Qiaolin]的文章
[Chen, Yao]的文章
[Ma, Xibo]的文章
百度学术
百度学术中相似的文章
[Wei, Qiaolin]的文章
[Chen, Yao]的文章
[Ma, Xibo]的文章
必应学术
必应学术中相似的文章
[Wei, Qiaolin]的文章
[Chen, Yao]的文章
[Ma, Xibo]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 10.1002@adfm.201704634.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。