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Prefrontal Volume Mediates Effect of COMT Polymorphism on Interference Resolution Capacity in Healthy Male Adults
Xu, Jiayuan1,2; Qin, Wen1,2; Li, Qiaojun3; Li, Wei1,2; Liu, Feng1,2; Liu, Bing4,5; Jiang, Tianzi4,5; Yu, Chunshui1,2
Source PublicationCEREBRAL CORTEX
2017-11-01
Volume27Issue:11Pages:5211-5221
SubtypeArticle
AbstractThere exist gender differences in the modulation of catechol-O-methyltransferase (COMT) Val158Met polymorphism on cognitive performance; however, the underlying gene-anatomy-cognition pathways remain unknown. Here we hypothesize that prefrontal volume may mediate the modulation of COMT Val158Met polymorphism on interference resolution capacity in a gender-dependent manner. In 261 healthy young human subjects (143 males and 118 females), a 2-way analysis of variance showed a COMT x gender interaction (P = 0.023) on interference resolution capacity. Val/Val subjects performed worse in Stroop interference test than Met/Met subjects only in males (P = 0.028). Voxel-wise analysis in the whole brain also exhibited a COMT x gender interaction on gray matter volume (GMV) in the left lateral frontal pole (FP). Val/Val male individuals exhibited significantly decreased GMV in the left lateral FP than Val/Met (P = 0.003) and Met/Met (P = 0.006) male carriers. Mediation analysis revealed that the GMV of the left lateral FP mediated the association between COMT polymorphism and interference resolution in males. These findings provide a gene-anatomy-cognition pathway to describe how COMT Val158Met polymorphism affects interference resolution capacity via modulating the prefrontal GMV in healthy male subjects.
KeywordCatechol-o-methyltransferase Gender Gray Matter Volume Mediation Analysis Stroop Interference Resolution
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1093/cercor/bhw301
WOS KeywordANTERIOR CINGULATE CORTEX ; METHYLTRANSFERASE VAL158MET GENOTYPE ; VAL(108/158) MET GENOTYPE ; GRAY-MATTER VOLUME ; COGNITIVE CONTROL ; STROOP TASK ; VAL(158)MET POLYMORPHISM ; SEX-DIFFERENCES ; FRONTAL-CORTEX ; DOWN-REGULATION
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNatural Science Foundation of China(81501451 ; 81425013 ; 81271551 ; 91132301 ; 81301201 ; 81301202)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000413209200013
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/20326
Collection脑网络组研究中心
Affiliation1.Tianjin Med Univ Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China
2.Tianjin Med Univ Gen Hosp, Tianjin Key Lab Funct Imaging, 154 Anshan Rd, Tianjin 300052, Peoples R China
3.Tianjin Univ Commerce, Coll Informat Engn, Tianjin 300052, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xu, Jiayuan,Qin, Wen,Li, Qiaojun,et al. Prefrontal Volume Mediates Effect of COMT Polymorphism on Interference Resolution Capacity in Healthy Male Adults[J]. CEREBRAL CORTEX,2017,27(11):5211-5221.
APA Xu, Jiayuan.,Qin, Wen.,Li, Qiaojun.,Li, Wei.,Liu, Feng.,...&Yu, Chunshui.(2017).Prefrontal Volume Mediates Effect of COMT Polymorphism on Interference Resolution Capacity in Healthy Male Adults.CEREBRAL CORTEX,27(11),5211-5221.
MLA Xu, Jiayuan,et al."Prefrontal Volume Mediates Effect of COMT Polymorphism on Interference Resolution Capacity in Healthy Male Adults".CEREBRAL CORTEX 27.11(2017):5211-5221.
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