Prefrontal Volume Mediates Effect of COMT Polymorphism on Interference Resolution Capacity in Healthy Male Adults

doi:10.1093/cercor/bhw301

	Prefrontal Volume Mediates Effect of COMT Polymorphism on Interference Resolution Capacity in Healthy Male Adults
	Xu, Jiayuan 1,2; Qin, Wen 1,2; Li, Qiaojun3 ; Li, Wei 1,2; Liu, Feng 1,2; Liu, Bing4,5 ; Jiang, Tianzi4,5 ; Yu, Chunshui 1,2
发表期刊	CEREBRAL CORTEX
	2017-11-01
卷号	27 期号:11 页码:5211-5221
文章类型	Article
摘要	There exist gender differences in the modulation of catechol-O-methyltransferase (COMT) Val158Met polymorphism on cognitive performance; however, the underlying gene-anatomy-cognition pathways remain unknown. Here we hypothesize that prefrontal volume may mediate the modulation of COMT Val158Met polymorphism on interference resolution capacity in a gender-dependent manner. In 261 healthy young human subjects (143 males and 118 females), a 2-way analysis of variance showed a COMT x gender interaction (P = 0.023) on interference resolution capacity. Val/Val subjects performed worse in Stroop interference test than Met/Met subjects only in males (P = 0.028). Voxel-wise analysis in the whole brain also exhibited a COMT x gender interaction on gray matter volume (GMV) in the left lateral frontal pole (FP). Val/Val male individuals exhibited significantly decreased GMV in the left lateral FP than Val/Met (P = 0.003) and Met/Met (P = 0.006) male carriers. Mediation analysis revealed that the GMV of the left lateral FP mediated the association between COMT polymorphism and interference resolution in males. These findings provide a gene-anatomy-cognition pathway to describe how COMT Val158Met polymorphism affects interference resolution capacity via modulating the prefrontal GMV in healthy male subjects.
关键词	Catechol-o-methyltransferase Gender Gray Matter Volume Mediation Analysis Stroop Interference Resolution
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1093/cercor/bhw301
关键词[WOS]	ANTERIOR CINGULATE CORTEX ; METHYLTRANSFERASE VAL158MET GENOTYPE ; VAL(108/158) MET GENOTYPE ; GRAY-MATTER VOLUME ; COGNITIVE CONTROL ; STROOP TASK ; VAL(158)MET POLYMORPHISM ; SEX-DIFFERENCES ; FRONTAL-CORTEX ; DOWN-REGULATION
收录类别	SCI ; SSCI
语种	英语
项目资助者	Natural Science Foundation of China(81501451 ; 81425013 ; 81271551 ; 91132301 ; 81301201 ; 81301202)
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000413209200013
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/20326
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Tianjin Med Univ Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China 2.Tianjin Med Univ Gen Hosp, Tianjin Key Lab Funct Imaging, 154 Anshan Rd, Tianjin 300052, Peoples R China 3.Tianjin Univ Commerce, Coll Informat Engn, Tianjin 300052, Peoples R China 4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Xu, Jiayuan,Qin, Wen,Li, Qiaojun,et al. Prefrontal Volume Mediates Effect of COMT Polymorphism on Interference Resolution Capacity in Healthy Male Adults[J]. CEREBRAL CORTEX,2017,27(11):5211-5221.
APA	Xu, Jiayuan.,Qin, Wen.,Li, Qiaojun.,Li, Wei.,Liu, Feng.,...&Yu, Chunshui.(2017).Prefrontal Volume Mediates Effect of COMT Polymorphism on Interference Resolution Capacity in Healthy Male Adults.CEREBRAL CORTEX,27(11),5211-5221.
MLA	Xu, Jiayuan,et al."Prefrontal Volume Mediates Effect of COMT Polymorphism on Interference Resolution Capacity in Healthy Male Adults".CEREBRAL CORTEX 27.11(2017):5211-5221.