Relationship between necrotic patterns in glioblastoma and patient survival: fractal dimension and lacunarity analyses using magnetic resonance imaging

doi:10.1038/s41598-017-08862-6

	Relationship between necrotic patterns in glioblastoma and patient survival: fractal dimension and lacunarity analyses using magnetic resonance imaging
	Liu, Shuai 1,2; Wang, Yinyan 1; Xu, Kaibin3 ; Wang, Zheng1,2 ; Fan, Xing 2; Zhang, Chuanbao 1,2; Li, Shaowu 2,4; Qiu, Xiaoguang 5; Jiang, Tao 1,2,6
发表期刊	SCIENTIFIC REPORTS
	2017-08-16
卷号	7
文章类型	Article
摘要	Necrosis is a hallmark feature of glioblastoma (GBM). This study investigated the prognostic role of necrotic patterns in GBM using fractal dimension (FD) and lacunarity analyses of magnetic resonance imaging (MRI) data and evaluated the role of lacunarity in the biological processes leading to necrosis. We retrospectively reviewed clinical and MRI data of 95 patients with GBM. FD and lacunarity of the necrosis on MRI were calculated by fractal analysis and subjected to survival analysis. We also performed gene ontology analysis in 32 patients with available RNA-seq data. Univariate analysis revealed that FD < 1.56 and lacunarity > 0.46 significantly correlated with poor progression-free survival (p = 0.006 and p = 0.012, respectively) and overall survival (p = 0.008 and p = 0.005, respectively). Multivariate analysis revealed that both parameters were independent factors for unfavorable progression-free survival (p = 0.001 and p = 0.015, respectively) and overall survival (p = 0.002 and p = 0.007, respectively). Gene ontology analysis revealed that genes positively correlated with lacunarity were involved in the suppression of apoptosis and necrosis-associated biological processes. We demonstrate that the fractal parameters of necrosis in GBM can predict patient survival and are associated with the biological processes of tumor necrosis.
WOS标题词	Science & Technology
DOI	10.1038/s41598-017-08862-6
关键词[WOS]	TUMOR-NECROSIS-FACTOR ; CELL-DEATH ; MULTIFORME ; ACTIVATION ; COMPLEXITY ; APOPTOSIS ; GLIOMAS ; CANCER
收录类别	SCI
语种	英语
项目资助者	Capital Medical Development Research Fund(2016-2-1073) ; National Key Research and Development Plan(2016YFC0902500) ; National Natural Science Foundation of China(81502495)
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000407674800001
引用统计	被引频次：45[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/20706
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China 2.Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 4.Capital Med Univ, Beijing Tiantan Hosp, Dept Neuroradiol, Beijing, Peoples R China 5.Capital Med Univ, Beijing Tiantan Hosp, Dept Radiat Oncol, Beijing, Peoples R China 6.Beijing Inst Brain Disorders, Ctr Brain Tumor, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Liu, Shuai,Wang, Yinyan,Xu, Kaibin,et al. Relationship between necrotic patterns in glioblastoma and patient survival: fractal dimension and lacunarity analyses using magnetic resonance imaging[J]. SCIENTIFIC REPORTS,2017,7.
APA	Liu, Shuai.,Wang, Yinyan.,Xu, Kaibin.,Wang, Zheng.,Fan, Xing.,...&Jiang, Tao.(2017).Relationship between necrotic patterns in glioblastoma and patient survival: fractal dimension and lacunarity analyses using magnetic resonance imaging.SCIENTIFIC REPORTS,7.
MLA	Liu, Shuai,et al."Relationship between necrotic patterns in glioblastoma and patient survival: fractal dimension and lacunarity analyses using magnetic resonance imaging".SCIENTIFIC REPORTS 7(2017).