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Identifying functional network changing patterns in individuals at clinical high-risk for psychosis and patients with early illness schizophrenia: A group ICA study
Du, Yuhui1,2; Fryer, Susanna L.3,4; Lin, Dongdong1; Sui, Jing1,5,6; Yu, Qingbao1; Chen, Jiayu1; Stuart, Barbara3; Loewy, Rachel L.3; Calhoun, Vince D.1,7; Mathalon, Daniel H.3,4
2018
发表期刊NEUROIMAGE-CLINICAL
卷号17期号:1页码:335-346
文章类型Article
摘要Although individuals at clinical high risk (CHR) for psychosis exhibit a psychosis-risk syndrome involving attenuated forms of the positive symptoms typical of schizophrenia (SZ), it remains unclear whether their resting-state brain intrinsic functional networks (INs) show attenuated or qualitatively distinct patterns of functional dysconnectivity relative to SZ patients. Based on resting-state functional magnetic imaging data from 70 healthy controls (HCs), 53 CHR individuals (among which 41 subjects were antipsychotic medication-naive), and 58 early illness SZ (ESZ) patients (among which 53 patients took antipsychotic medication) within five years of illness onset, we estimated subject-specific INs using a novel group information guided independent component analysis (GIG-ICA) and investigated group differences in INs. We found that when compared to HCs, both CHR and ESZ groups showed significant differences, primarily in default mode, salience, auditory-related, visuospatial, sensory-motor, and parietal INs. Our findings suggest that widespread INs were diversely impacted. More than 25% of voxels in the identified significant discriminative regions (obtained using all 19 possible changing patterns excepting the no-difference pattern) from six of the 15 interrogated INs exhibited monotonically decreasing Z-scores (in INs) from the HC to CHR to ESZ, and the related regions included the left lingual gyrus of two vision-related networks, the right postcentral cortex of the visuospatial network, the left thalamus region of the salience network, the left calcarine region of the fronto-occipital network and fronto-parieto-occipital network. Compared to HCs and CHR individuals, ESZ patients showed both increasing and decreasing connectivity, mainly hypo-connectivity involving 15% of the altered voxels from four INs. The left supplementary motor area from the sensory-motor network and the right inferior occipital gyrus in the vision-related network showed a common abnormality in CHR and ESZ groups. Some brain regions also showed a CHR-unique alteration (primarily the CHR-increasing connectivity). In summary, CHR individuals generally showed intermediate connectivity between HCs and ESZ patients across multiple INs, suggesting that some dysconnectivity patterns evident in ESZ predate psychosis in attenuated form during the psychosis risk stage. Hence, these connectivity measures may serve as possible biomarkers to predict schizophrenia progression.
关键词Schizophrenia Psychosis-risk Syndrome Resting-state Functional Magnetic Resonance Imaging Brain Intrinsic Functional Networks Independent Component Analysis
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.nicl.2017.10.018
关键词[WOS]DEFAULT MODE NETWORK ; RESTING-STATE ; BIPOLAR DISORDER ; SCHIZOAFFECTIVE DISORDERS ; BRAIN NETWORKS ; CONNECTIVITY ; FMRI ; SCALE ; DYSCONNECTIVITY ; COGNITION
收录类别SCI
语种英语
项目资助者National Institutes of Health (NIH)(R01MH076989 ; National Science Foundation(1539067) ; National Natural Science Foundation of China(61703253) ; Natural Science Foundation of Shanxi Province(2016021077) ; P20RR021938/P20GM103472 ; R01EB006841 ; R01EB020407)
WOS研究方向Neurosciences & Neurology
WOS类目Neuroimaging
WOS记录号WOS:000426180300036
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/20799
专题脑网络组研究中心
作者单位1.Mind Res Network, 1101 Yale Blvd NE, Albuquerque, NM 87131 USA
2.Shanxi Univ, Sch Comp & Informat Technol, Taiyuan, Shanxi, Peoples R China
3.Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
4.San Francisco VA Healthcare Syst, Mental Hlth Serv, 116d,4150 Clement St, San Francisco, CA 94121 USA
5.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China
6.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China
7.Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA
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Du, Yuhui,Fryer, Susanna L.,Lin, Dongdong,et al. Identifying functional network changing patterns in individuals at clinical high-risk for psychosis and patients with early illness schizophrenia: A group ICA study[J]. NEUROIMAGE-CLINICAL,2018,17(1):335-346.
APA Du, Yuhui.,Fryer, Susanna L..,Lin, Dongdong.,Sui, Jing.,Yu, Qingbao.,...&Mathalon, Daniel H..(2018).Identifying functional network changing patterns in individuals at clinical high-risk for psychosis and patients with early illness schizophrenia: A group ICA study.NEUROIMAGE-CLINICAL,17(1),335-346.
MLA Du, Yuhui,et al."Identifying functional network changing patterns in individuals at clinical high-risk for psychosis and patients with early illness schizophrenia: A group ICA study".NEUROIMAGE-CLINICAL 17.1(2018):335-346.
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