Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia

doi:10.1093/schbul/sbx068

	Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia
	Lin, Dongdong 1,2; Chen, Jiayu 1,2; Ehrlich, Stefan 3; Bustillo, Juan R.4,5; Perrone-Bizzozero, Nora 4,5; Walton, Esther 6; Clark, Vincent P.1,2,7; Wang, Yu-Ping 8; Sui, Jing 1,2,9,10; Du, Yuhui 1,2,11; Ho, Beng C.12; Schulz, Charles S.13; Calhoun, Vince D.1,2,4,14; Liu, Jingyu1,2,14
发表期刊	SCHIZOPHRENIA BULLETIN
	2018-03-01
卷号	44 期号:2 页码:443-452
文章类型	Article
摘要	Closely linking genetics and environment factors, epigenetics has been of increasing interest in psychiatric disease studies. In this work, we integrated single nucleotide polymorphisms (SNPs), DNA methylation of blood and saliva, and brain gray matter (GM) measures to explore the role of genetic and epigenetic variation to the brain structure changes in schizophrenia (SZ). By focusing on the reported SZ genetic risk regions, we applied a multi-stage multivariate analysis to a discovery dataset (92 SZ patients and 110 controls, blood) and an independent replication dataset (93 SZ patients and 99 controls, saliva). Two pairs of SNP-methylation components were significantly correlated (r = .48 and .35) in blood DNA, and replicated (r = .46 and .29) in saliva DNA, reflecting cross-tissue SNP cis-effects. In the discovery data, both SNP-related methylation components were also associated with one GM component primarily located in cerebellum, caudate, and thalamus. Additionally, another methylation component in NOSIP gene with significant SZ patient differences (P = .009), was associated with 8 GM components (7 with patient differences) including superior, middle, and inferior frontal gyri, superior, middle, and inferior temporal gyri, cerebellum, insula, cuneus, and lingual gyrus. Of these, 5 methylation-GM associations were replicated (P < .05). In contrast, no pairwise significant associations were observed between SNP and GM components. This study strongly supports that compared to genetic variation, epigenetics show broader and more significant associations with brain structure as well as diagnosis, which can be cross-tissue, and the potential in explaining the mechanism of genetic risks in SZ.
关键词	Brain Gray Matter Cross-tissue Dna Methylation Genetics Meqtl Schizophrenia
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1093/schbul/sbx068
关键词[WOS]	NITRIC-OXIDE SYNTHASE ; INDEPENDENT COMPONENT ANALYSIS ; DNA METHYLATION ; INTERMEDIATE PHENOTYPES ; WIDE ASSOCIATION ; CORTEX ; RISK ; DISORDERS ; DISEASE ; BLOOD
收录类别	SCI ; SSCI
语种	英语
项目资助者	National Institutes of Health(P20GM103472 ; National Science Foundation(1539067) ; R01EB005846)
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000427534200026
引用统计	被引频次：20[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/20800
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Mind Res Network, Albuquerque, NM 87106 USA 2.Lovelace Biomed & Environm Res Inst, Albuquerque, NM 87106 USA 3.Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Dresden, Germany 4.Univ New Mexico, Dept Neurosci, Albuquerque, NM 87131 USA 5.Univ New Mexico, Dept Psychiat, Albuquerque, NM USA 6.Georgia State Univ, Dept Psychol, Univ Plaza, Atlanta, GA 30303 USA 7.Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA 8.Tulane Univ, Dept Biomed Engn, New Orleans, LA 70118 USA 9.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 10.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 11.Shanxi Univ, Sch Comp & Informat Technol, Taiyuan, Shanxi, Peoples R China 12.Univ Iowa, Dept Psychiat, Carver Coll Med, Iowa City, IA 52242 USA 13.Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA 14.Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA
推荐引用方式 GB/T 7714	Lin, Dongdong,Chen, Jiayu,Ehrlich, Stefan,et al. Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia[J]. SCHIZOPHRENIA BULLETIN,2018,44(2):443-452.
APA	Lin, Dongdong.,Chen, Jiayu.,Ehrlich, Stefan.,Bustillo, Juan R..,Perrone-Bizzozero, Nora.,...&Liu, Jingyu.(2018).Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia.SCHIZOPHRENIA BULLETIN,44(2),443-452.
MLA	Lin, Dongdong,et al."Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia".SCHIZOPHRENIA BULLETIN 44.2(2018):443-452.