Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Preoperative Examination and Intraoperative Identification of Hepatocellular Carcinoma Using a Targeted Bimodal Imaging Probe | |
Jin, Yushen1,3; Wang, Kun1,3; Tian, Jie1,2,3,4 | |
发表期刊 | BIOCONJUGATE CHEMISTRY |
2018-04-01 | |
卷号 | 29期号:4页码:1475-1484 |
文章类型 | Article |
摘要 | In dinical imaging modalities, MRI is suitable for preoperative examination. Fluorescence imaging has been proposed to improve the detectability of cancer lesions during the operation. However, the specificity and accuracy of the two imaging modalities is limited. To improve the prognosis and survival rate of the patient suffering from hepatocellular carcinoma (HCC), it is very important to develop a specific probe to achieve early detection and precise resection of HCC. We selected HCC targeting peptide SP94 to conjugate with a NIR dye and Gd chelated DOTA to enhance the specificity of different imaging modalities. MRI and fluorescence imaging were used for preoperative examination of the cancer and detecting the tumor in the operation, respectively. MRI and fluorescence signals significantly increased when HCC occurs and the obtained probe shows high uptake in HCC but negligible uptake in the normal liver tissues. The signal-to-background ratio is higher than 2.23 (MRI) and 2.0 (fluorescence imaging) with noninvasive imaging modalities. After the intraperitoneal cavity was surgically exposed, the signal-to-background ratio is higher than 4.6. By combining the high specificity of our probe with the high sensitivity of fluorescence imaging, the microprimary malignancy and micrometastasis foci (diameter <1 mm) can be easily detected after the intraperitoneal cavity is exposed. These results indicated that our probe is conductive to the early detection and precise resection of the HCC and has the potential to improve the diagnosis and treatment of patients with HCC. |
关键词 | Fluorescence Imaging Mri Hepatocellular Carcinoma Sp94 Peptide Imaging-guided Surgery |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
DOI | 10.1021/acs.bioconjchem.8b00161 |
关键词[WOS] | CLINICAL-APPLICATIONS ; OVARIAN-CANCER ; QUANTUM DOTS ; LIVER ; DELIVERY ; DIAGNOSIS ; NANOPARTICLES ; METASTASES ; THERAPY ; SURGERY |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | National Key Research and Development Program of China(2017YFA0205200 ; National Natural Science Foundation of China(81701771 ; International Innovation Team of CAS(20140491524) ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; 2015CB755500 ; 81227901 ; 2016YFA0201401) ; 81527805 ; 61231004) |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
WOS类目 | Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic |
WOS记录号 | WOS:000430641700070 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/21692 |
专题 | 中国科学院分子影像重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 3.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100080, Peoples R China |
第一作者单位 | 中国科学院分子影像重点实验室 |
推荐引用方式 GB/T 7714 | Jin, Yushen,Wang, Kun,Tian, Jie. Preoperative Examination and Intraoperative Identification of Hepatocellular Carcinoma Using a Targeted Bimodal Imaging Probe[J]. BIOCONJUGATE CHEMISTRY,2018,29(4):1475-1484. |
APA | Jin, Yushen,Wang, Kun,&Tian, Jie.(2018).Preoperative Examination and Intraoperative Identification of Hepatocellular Carcinoma Using a Targeted Bimodal Imaging Probe.BIOCONJUGATE CHEMISTRY,29(4),1475-1484. |
MLA | Jin, Yushen,et al."Preoperative Examination and Intraoperative Identification of Hepatocellular Carcinoma Using a Targeted Bimodal Imaging Probe".BIOCONJUGATE CHEMISTRY 29.4(2018):1475-1484. |
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