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Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma
Fan, Kelong1; Jia, Xiaohua; Zhou, Meng1,3; Wang, Kun2; Conde, Joao4; He, Jiuyang1; Tian, Jie2; Yan, Xiyun1,3
2018-05-01
发表期刊ACS NANO
卷号12期号:5页码:4105-4115
文章类型Article
摘要
; Over the last decades, considerable efforts have been put into developing active nanocarrier systems that cross the blood brain barrier (BBB) to treat brain-related diseases such as glioma tumors. However, to date none have been approved for clinical usage. Here, we show that a human H-ferritin (HFn) nanocarrier both successfully crosses the BBB and kills glioma tumor cells. Its principle point of entry is the HFn receptor (transferrin receptor 1), which is overexpressed in both BBB endothelial cells (ECs) and glioma cells. Importantly, we found that HFn enters and exits the BBB via the endosome compartment. In contrast, upon specifically targeting and entering glioma cells, nearly all of the HFn accumulated in the lysosomal compartment, resulting in the killing of glioma tumor cells, with no HFn accumulation in the surrounding healthy brain tissue. Thus, HFn is an ideal nanocarrier for glioma therapy and possesses the potential to serve as a therapeutic approach against a broad range of central nervous system diseases.
关键词Human H-ferritin Nanocarrier Blood Brain Barrier Transferrin Receptor 1 Receptor-mediated Transcytosis Glioma-targeted Therapy
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1021/acsnano.7b06969
关键词[WOS]RECEPTOR-MEDIATED ENDOCYTOSIS ; TRANSFERRIN RECEPTOR ; DRUG-DELIVERY ; H-FERRITIN ; BINDING-SITES ; NANOPARTICLES ; GLIOBLASTOMA ; TUMORS ; PATHWAY ; CANCER
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(31530026 ; CAST(2015QNRC001) ; China Postdoctoral Science Foundation(2015M570158) ; China Postdoctoral Science Special Foundation(2016T90143) ; Key Research Program of Frontier Sciences(QYZDY-SSW-SMC013) ; Chinese Academy of Sciences ; National Key Research and Development Program of China(2017YFA0205200) ; (XDA09030306) ; (XDPB0304) ; 81527805 ; 61231004)
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000433404500005
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21789
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Key Lab Prot & Peptide Pharmaceut, CAS Univ Tokyo Joint Lab Struct Virol & Immunol, Inst Biophys, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Queen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, England
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Fan, Kelong,Jia, Xiaohua,Zhou, Meng,et al. Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma[J]. ACS NANO,2018,12(5):4105-4115.
APA Fan, Kelong.,Jia, Xiaohua.,Zhou, Meng.,Wang, Kun.,Conde, Joao.,...&Yan, Xiyun.(2018).Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma.ACS NANO,12(5),4105-4115.
MLA Fan, Kelong,et al."Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma".ACS NANO 12.5(2018):4105-4115.
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