Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma

doi:10.1021/acsnano.7b06969

	Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma
	Fan, Kelong 1; Jia, Xiaohua; Zhou, Meng 1,3; Wang, Kun2 ; Conde, Joao 4; He, Jiuyang 1; Tian, Jie 2; Yan, Xiyun 1,3
发表期刊	ACS NANO
	2018-05-01
卷号	12 期号:5 页码:4105-4115
文章类型	Article
摘要	; Over the last decades, considerable efforts have been put into developing active nanocarrier systems that cross the blood brain barrier (BBB) to treat brain-related diseases such as glioma tumors. However, to date none have been approved for clinical usage. Here, we show that a human H-ferritin (HFn) nanocarrier both successfully crosses the BBB and kills glioma tumor cells. Its principle point of entry is the HFn receptor (transferrin receptor 1), which is overexpressed in both BBB endothelial cells (ECs) and glioma cells. Importantly, we found that HFn enters and exits the BBB via the endosome compartment. In contrast, upon specifically targeting and entering glioma cells, nearly all of the HFn accumulated in the lysosomal compartment, resulting in the killing of glioma tumor cells, with no HFn accumulation in the surrounding healthy brain tissue. Thus, HFn is an ideal nanocarrier for glioma therapy and possesses the potential to serve as a therapeutic approach against a broad range of central nervous system diseases.
关键词	Human H-ferritin Nanocarrier Blood Brain Barrier Transferrin Receptor 1 Receptor-mediated Transcytosis Glioma-targeted Therapy
WOS标题词	Science & Technology ; Physical Sciences ; Technology
DOI	10.1021/acsnano.7b06969
关键词[WOS]	RECEPTOR-MEDIATED ENDOCYTOSIS ; TRANSFERRIN RECEPTOR ; DRUG-DELIVERY ; H-FERRITIN ; BINDING-SITES ; NANOPARTICLES ; GLIOBLASTOMA ; TUMORS ; PATHWAY ; CANCER
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(31530026 ; CAST(2015QNRC001) ; China Postdoctoral Science Foundation(2015M570158) ; China Postdoctoral Science Special Foundation(2016T90143) ; Key Research Program of Frontier Sciences(QYZDY-SSW-SMC013) ; Chinese Academy of Sciences ; National Key Research and Development Program of China(2017YFA0205200) ; (XDA09030306) ; (XDPB0304) ; 81527805 ; 61231004)
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000433404500005
引用统计	被引频次：235[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/21789
专题	中国科学院分子影像重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Prot & Peptide Pharmaceut, CAS Univ Tokyo Joint Lab Struct Virol & Immunol, Inst Biophys, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Queen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, England
推荐引用方式 GB/T 7714	Fan, Kelong,Jia, Xiaohua,Zhou, Meng,et al. Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma[J]. ACS NANO,2018,12(5):4105-4115.
APA	Fan, Kelong.,Jia, Xiaohua.,Zhou, Meng.,Wang, Kun.,Conde, Joao.,...&Yan, Xiyun.(2018).Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma.ACS NANO,12(5),4105-4115.
MLA	Fan, Kelong,et al."Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma".ACS NANO 12.5(2018):4105-4115.

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