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Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma
Fan, Kelong1; Jia, Xiaohua; Zhou, Meng1,3; Wang, Kun2; Conde, Joao4; He, Jiuyang1; Tian, Jie2; Yan, Xiyun1,3
Source PublicationACS NANO
; Over the last decades, considerable efforts have been put into developing active nanocarrier systems that cross the blood brain barrier (BBB) to treat brain-related diseases such as glioma tumors. However, to date none have been approved for clinical usage. Here, we show that a human H-ferritin (HFn) nanocarrier both successfully crosses the BBB and kills glioma tumor cells. Its principle point of entry is the HFn receptor (transferrin receptor 1), which is overexpressed in both BBB endothelial cells (ECs) and glioma cells. Importantly, we found that HFn enters and exits the BBB via the endosome compartment. In contrast, upon specifically targeting and entering glioma cells, nearly all of the HFn accumulated in the lysosomal compartment, resulting in the killing of glioma tumor cells, with no HFn accumulation in the surrounding healthy brain tissue. Thus, HFn is an ideal nanocarrier for glioma therapy and possesses the potential to serve as a therapeutic approach against a broad range of central nervous system diseases.
KeywordHuman H-ferritin Nanocarrier Blood Brain Barrier Transferrin Receptor 1 Receptor-mediated Transcytosis Glioma-targeted Therapy
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(31530026 ; CAST(2015QNRC001) ; China Postdoctoral Science Foundation(2015M570158) ; China Postdoctoral Science Special Foundation(2016T90143) ; Key Research Program of Frontier Sciences(QYZDY-SSW-SMC013) ; Chinese Academy of Sciences ; National Key Research and Development Program of China(2017YFA0205200) ; (XDA09030306) ; (XDPB0304) ; 81527805 ; 61231004)
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000433404500005
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Cited Times:229[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Key Lab Prot & Peptide Pharmaceut, CAS Univ Tokyo Joint Lab Struct Virol & Immunol, Inst Biophys, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Queen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, England
Recommended Citation
GB/T 7714
Fan, Kelong,Jia, Xiaohua,Zhou, Meng,et al. Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma[J]. ACS NANO,2018,12(5):4105-4115.
APA Fan, Kelong.,Jia, Xiaohua.,Zhou, Meng.,Wang, Kun.,Conde, Joao.,...&Yan, Xiyun.(2018).Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma.ACS NANO,12(5),4105-4115.
MLA Fan, Kelong,et al."Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma".ACS NANO 12.5(2018):4105-4115.
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