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Graphene Oxide Modified PLA Microcapsules Containing Gold Nanoparticles for Ultrasonic/CT Bimodal Imaging Guided Photothermal Tumor Therapy
Jin Yushen; Wang Jinrui; Ke Hengte; Wang Shumin; Dai Zhifei
2013-04-01
发表期刊Biomaterials
期号34页码:4794-4802
摘要Theranostic microcapsules were successfully fabricated by introducing gold nanoparticles into poly(lactic acid) microcapsules through a double-microemulsion method, followed by depositing graphene oxide onto the microcapsule surface via electrostatic layer-by-layer self-assembly technique. It was proved that the obtained microcapsules could serve as a contrast agent to simultaneously enhance US imaging and X-ray CT imaging greatly both in vitro and in vivo. In addition, the in vivo therapeutic examinations showed that the microcapsule was an effective agent for photothermal therapy of cancer. The nearinfrared laser light ablated the tumor completely within 9 days in the presence of the microcapsules and the tumor growth inhibition was 83.8%. The combination of real-time ultrasound with 3-D computed tomography through a single microcapsule agent is very helpful for accurately interpreting the obtained images, identifying the size and location of the tumor, as well as guiding and monitoring the photothermal therapy. Simultaneously, the effectiveness of photothermal therapy could be evaluated by the combined US and CT imaging enhanced by the microcapsule agent. Such a versatile microcapsule system might bring opportunities to the next generation of multimodal imaging guided cancer therapy.
Crown Copyright
 2013 Published by Elsevier Ltd. All rights reserved
关键词Microcapsules Photothermal Therapy Computed Tomography Ultrasound Imaging Theranostic Agent
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21807
专题中国科学院分子影像重点实验室
推荐引用方式
GB/T 7714
Jin Yushen,Wang Jinrui,Ke Hengte,et al. Graphene Oxide Modified PLA Microcapsules Containing Gold Nanoparticles for Ultrasonic/CT Bimodal Imaging Guided Photothermal Tumor Therapy[J]. Biomaterials,2013(34):4794-4802.
APA Jin Yushen,Wang Jinrui,Ke Hengte,Wang Shumin,&Dai Zhifei.(2013).Graphene Oxide Modified PLA Microcapsules Containing Gold Nanoparticles for Ultrasonic/CT Bimodal Imaging Guided Photothermal Tumor Therapy.Biomaterials(34),4794-4802.
MLA Jin Yushen,et al."Graphene Oxide Modified PLA Microcapsules Containing Gold Nanoparticles for Ultrasonic/CT Bimodal Imaging Guided Photothermal Tumor Therapy".Biomaterials .34(2013):4794-4802.
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