Liposomal nanohybrid cerasomes for controlled insulin release

	Liposomal nanohybrid cerasomes for controlled insulin release
	Jin Yushen; Li Yanyan; Pan Hongjie; Dai Zhifei
发表期刊	RSC Advances
	2014-09-04
期号	4 页码:42808–42815
摘要	This study reported a facile fabrication of a reproducible and injectable cerasomal insulin formulation by encapsulating insulin into cerasomes via one-step construction. Notably, a wide range of the insulin release profiles was achieved by altering vesicle composition through incorporating the phospholipid of DPPC into cerasomes, and the mixed cerasomes showed excellent storage stability when the percentage content of DPPC was lower than 50%. It was found that the subcutaneous administration of the insulin-loaded cerasomes resulted in a reduction of blood glucose levels in a rat model of type I diabetes and the hypoglycemic effect was found to be composition dependent. The use of cerasomes significantly improved glucose tolerance from 6 hours (free insulin) to more than 16 hours (insulinloaded cerasomes). Moreover, the insulin-loaded cerasomes displayed a prolonged and stable glucoselowering profile over a period of over 12 hours compared with the insulin-loaded liposomes. These findings demonstrate that cerasomes have good potential for the use in an effective controlled release delivery system of insulin as well as other proteins with short half-life time.
关键词	无
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/21811
专题	中国科学院分子影像重点实验室
推荐引用方式 GB/T 7714	Jin Yushen,Li Yanyan,Pan Hongjie,et al. Liposomal nanohybrid cerasomes for controlled insulin release[J]. RSC Advances,2014(4):42808–42815.
APA	Jin Yushen,Li Yanyan,Pan Hongjie,&Dai Zhifei.(2014).Liposomal nanohybrid cerasomes for controlled insulin release.RSC Advances(4),42808–42815.
MLA	Jin Yushen,et al."Liposomal nanohybrid cerasomes for controlled insulin release".RSC Advances .4(2014):42808–42815.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Liposomalnanohybridc（1104KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载