Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex | |
Wang, Zhengchun1,2,3; Yu, Shan4,5,6; Fu, Yu7; Tzvetanov, Tzvetomir1,2,8; Zhou, Yifeng1,2,9 | |
发表期刊 | FRONTIERS IN AGING NEUROSCIENCE |
2018-02-05 | |
卷号 | 10 |
文章类型 | Article |
摘要 | Aging-related declines in vision can decrease well-being of the elderly. Concerning early sensory changes as in the primary visual cortex, physiological and behavioral reports seem contradictory. Neurophysiological studies on orientation tuning properties suggested that neuronal changes might come from decreased cortical local inhibition. However, behavioral results either showed no clear deficits in orientation processing in older adults, or proposed stronger surround suppression. Through psychophysical experiments and computational modeling, we resolved these discrepancies by suggesting that lateral inhibition increased in older adults while neuronal orientation tuning widths, related to local inhibition, stayed globally intact across age. We confirmed this later result by re-analyzing published neurophysiological data, which showed no systematic tuning width changes, but instead displayed a higher neuronal noise with aging. These results suggest a stronger lateral inhibition and mixed effects on local inhibition during aging, revealing a more complex picture of age-related effects in the central visual system than people previously thought. |
关键词 | Behavioral Measure Computational Modeling Neurophysiology Early Visual Processing Senescence |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.3389/fnagi.2018.00014 |
关键词[WOS] | SENESCENT RHESUS-MONKEYS ; MIDDLE TEMPORAL AREA ; CORTICAL-CELLS ; FUNCTIONAL DEGRADATION ; CONTEXTUAL INTERACTIONS ; SPATIAL-DISTRIBUTION ; TILT ILLUSIONS ; OLDER-ADULTS ; AGED RATS ; SELECTIVITY |
收录类别 | SCI ; SSCI |
语种 | 英语 |
项目资助者 | National Natural Science Foundation of China(31230032) ; China Postdoctoral Science Foundation(2015M571940) ; Fundamental Research Funds for the Central Universities ; Hundred-Talent Program of the Chinese Academy of Sciences ; K. C. Wong Magna Fund in Ningbo University |
WOS研究方向 | Geriatrics & Gerontology ; Neurosciences & Neurology |
WOS类目 | Geriatrics & Gerontology ; Neurosciences |
WOS记录号 | WOS:000424118500001 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/21945 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
作者单位 | 1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei, Anhui, Peoples R China 2.Univ Sci & Technol China, Sch Life Sci, Hefei, Anhui, Peoples R China 3.Ningbo Univ, Med Sch, Dept Physiol & Pharmacol, Ningbo, Zhejiang, Peoples R China 4.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 6.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China 7.Kunming Univ Sci & Technol, Med Sch, Dept Basic Med, Kunming, Yunnan, Peoples R China 8.Hefei Univ Technol, Sch Comp & Informat, Hefei, Anhui, Peoples R China 9.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Zhengchun,Yu, Shan,Fu, Yu,et al. Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex[J]. FRONTIERS IN AGING NEUROSCIENCE,2018,10. |
APA | Wang, Zhengchun,Yu, Shan,Fu, Yu,Tzvetanov, Tzvetomir,&Zhou, Yifeng.(2018).Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex.FRONTIERS IN AGING NEUROSCIENCE,10. |
MLA | Wang, Zhengchun,et al."Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex".FRONTIERS IN AGING NEUROSCIENCE 10(2018). |
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