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Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex
Wang, Zhengchun1,2,3; Yu, Shan4,5,6; Fu, Yu7; Tzvetanov, Tzvetomir1,2,8; Zhou, Yifeng1,2,9
2018-02-05
发表期刊FRONTIERS IN AGING NEUROSCIENCE
卷号10
文章类型Article
摘要Aging-related declines in vision can decrease well-being of the elderly. Concerning early sensory changes as in the primary visual cortex, physiological and behavioral reports seem contradictory. Neurophysiological studies on orientation tuning properties suggested that neuronal changes might come from decreased cortical local inhibition. However, behavioral results either showed no clear deficits in orientation processing in older adults, or proposed stronger surround suppression. Through psychophysical experiments and computational modeling, we resolved these discrepancies by suggesting that lateral inhibition increased in older adults while neuronal orientation tuning widths, related to local inhibition, stayed globally intact across age. We confirmed this later result by re-analyzing published neurophysiological data, which showed no systematic tuning width changes, but instead displayed a higher neuronal noise with aging. These results suggest a stronger lateral inhibition and mixed effects on local inhibition during aging, revealing a more complex picture of age-related effects in the central visual system than people previously thought.
关键词Behavioral Measure Computational Modeling Neurophysiology Early Visual Processing Senescence
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.3389/fnagi.2018.00014
关键词[WOS]SENESCENT RHESUS-MONKEYS ; MIDDLE TEMPORAL AREA ; CORTICAL-CELLS ; FUNCTIONAL DEGRADATION ; CONTEXTUAL INTERACTIONS ; SPATIAL-DISTRIBUTION ; TILT ILLUSIONS ; OLDER-ADULTS ; AGED RATS ; SELECTIVITY
收录类别SCI ; SSCI
语种英语
项目资助者National Natural Science Foundation of China(31230032) ; China Postdoctoral Science Foundation(2015M571940) ; Fundamental Research Funds for the Central Universities ; Hundred-Talent Program of the Chinese Academy of Sciences ; K. C. Wong Magna Fund in Ningbo University
WOS研究方向Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目Geriatrics & Gerontology ; Neurosciences
WOS记录号WOS:000424118500001
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21945
专题脑网络组研究中心
作者单位1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei, Anhui, Peoples R China
2.Univ Sci & Technol China, Sch Life Sci, Hefei, Anhui, Peoples R China
3.Ningbo Univ, Med Sch, Dept Physiol & Pharmacol, Ningbo, Zhejiang, Peoples R China
4.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
6.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
7.Kunming Univ Sci & Technol, Med Sch, Dept Basic Med, Kunming, Yunnan, Peoples R China
8.Hefei Univ Technol, Sch Comp & Informat, Hefei, Anhui, Peoples R China
9.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
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Wang, Zhengchun,Yu, Shan,Fu, Yu,et al. Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex[J]. FRONTIERS IN AGING NEUROSCIENCE,2018,10.
APA Wang, Zhengchun,Yu, Shan,Fu, Yu,Tzvetanov, Tzvetomir,&Zhou, Yifeng.(2018).Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex.FRONTIERS IN AGING NEUROSCIENCE,10.
MLA Wang, Zhengchun,et al."Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex".FRONTIERS IN AGING NEUROSCIENCE 10(2018).
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