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Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex
Wang, Zhengchun1,2,3; Yu, Shan4,5,6; Fu, Yu7; Tzvetanov, Tzvetomir1,2,8; Zhou, Yifeng1,2,9
Source PublicationFRONTIERS IN AGING NEUROSCIENCE
2018-02-05
Volume10
SubtypeArticle
AbstractAging-related declines in vision can decrease well-being of the elderly. Concerning early sensory changes as in the primary visual cortex, physiological and behavioral reports seem contradictory. Neurophysiological studies on orientation tuning properties suggested that neuronal changes might come from decreased cortical local inhibition. However, behavioral results either showed no clear deficits in orientation processing in older adults, or proposed stronger surround suppression. Through psychophysical experiments and computational modeling, we resolved these discrepancies by suggesting that lateral inhibition increased in older adults while neuronal orientation tuning widths, related to local inhibition, stayed globally intact across age. We confirmed this later result by re-analyzing published neurophysiological data, which showed no systematic tuning width changes, but instead displayed a higher neuronal noise with aging. These results suggest a stronger lateral inhibition and mixed effects on local inhibition during aging, revealing a more complex picture of age-related effects in the central visual system than people previously thought.
KeywordBehavioral Measure Computational Modeling Neurophysiology Early Visual Processing Senescence
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.3389/fnagi.2018.00014
WOS KeywordSENESCENT RHESUS-MONKEYS ; MIDDLE TEMPORAL AREA ; CORTICAL-CELLS ; FUNCTIONAL DEGRADATION ; CONTEXTUAL INTERACTIONS ; SPATIAL-DISTRIBUTION ; TILT ILLUSIONS ; OLDER-ADULTS ; AGED RATS ; SELECTIVITY
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31230032) ; China Postdoctoral Science Foundation(2015M571940) ; Fundamental Research Funds for the Central Universities ; Hundred-Talent Program of the Chinese Academy of Sciences ; K. C. Wong Magna Fund in Ningbo University
WOS Research AreaGeriatrics & Gerontology ; Neurosciences & Neurology
WOS SubjectGeriatrics & Gerontology ; Neurosciences
WOS IDWOS:000424118500001
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/21945
Collection脑网络组研究中心
Affiliation1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei, Anhui, Peoples R China
2.Univ Sci & Technol China, Sch Life Sci, Hefei, Anhui, Peoples R China
3.Ningbo Univ, Med Sch, Dept Physiol & Pharmacol, Ningbo, Zhejiang, Peoples R China
4.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
6.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
7.Kunming Univ Sci & Technol, Med Sch, Dept Basic Med, Kunming, Yunnan, Peoples R China
8.Hefei Univ Technol, Sch Comp & Informat, Hefei, Anhui, Peoples R China
9.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Zhengchun,Yu, Shan,Fu, Yu,et al. Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex[J]. FRONTIERS IN AGING NEUROSCIENCE,2018,10.
APA Wang, Zhengchun,Yu, Shan,Fu, Yu,Tzvetanov, Tzvetomir,&Zhou, Yifeng.(2018).Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex.FRONTIERS IN AGING NEUROSCIENCE,10.
MLA Wang, Zhengchun,et al."Aging Potentiates Lateral but Not Local Inhibition of Orientation Processing in Primary Visual Cortex".FRONTIERS IN AGING NEUROSCIENCE 10(2018).
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