CASIA OpenIR  > 中国科学院分子影像重点实验室
Altered interhemispheric resting-state functional connectivity in young male smokers
Yu, Dahua1; Yuan, Kai1,2; Bi, Yanzhi2; Luo, Lin3; Zhai, Jinquan3; Liu, Bo3; Li, Yangding4; Cheng, Jiadong2; Guan, Yanyan2; Xue, Ting1; Bu, Limei1; Su, Shaoping1; Ma, Yao1; Qin, Wei2; Tian, Jie2,5; Lu, Xiaoqi1
Source PublicationADDICTION BIOLOGY
2018-03-01
Volume23Issue:2Pages:772-780
SubtypeArticle
AbstractWith the help of advanced neuroimaging approaches, previous studies revealed structural and functional brain changes in smokers compared with healthy non-smokers. Homotopic resting-state functional connectivity between the corresponding regions in cerebral hemispheres may help us to deduce the changes of functional coordination in the whole brain of young male smokers. Functional homotopy reflects an essential aspect of brain function and communication between the left and right cerebral hemispheres, which is important for the integrity of brain function. However, few studies used voxel mirrored homotopic connectivity (VMHC) method to investigate the changes of homotopic connectivity in young male smokers. Twenty-seven young male smokers and 27 matched healthy male non-smokers were recruited in our study. Compared with healthy male non-smokers, young male smokers showed decreased VMHC values in the insula and putamen, and increased VMHC values in the prefrontal cortex. Correlation analysis demonstrated that there were significant positive correlations between the average VMHC values of the prefrontal cortex and pack-years in young male smokers. In addition, significant negative correlation was found between the average VMHC values in the insula and pack-years. Our results revealed the disrupted homotopic resting-state functional connectivity in young male smokers. The novel findings may extend our understanding of smoking.
KeywordResting State Smoking Voxel Mirrored Homotopic Connectivity (Vmhc)
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1111/adb.12515
WOS KeywordADOLESCENT NICOTINE EXPOSURE ; WHITE-MATTER MICROSTRUCTURE ; PREFRONTAL CORTEX ; CORPUS-CALLOSUM ; CIGARETTE-SMOKING ; ORBITOFRONTAL CORTEX ; REGIONAL HOMOGENEITY ; BRAIN NETWORKS ; TOBACCO-SMOKE ; ADDICTION
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81571753 ; Fundamental Research Funds for the Central Universities(JB151204 ; Natural Science Foundation of Inner Mongolia(2014BS0610 ; Innovation Fund Project of Inner Mongolia University of Science and Technology(2015QNGG03 ; General Financial Grant the China Post-doctoral Science Foundation(2014 M552416) ; 81571751 ; JB121405) ; 2015MS0604) ; 2014QDL002) ; 81301281 ; 81401488 ; 61179019 ; 81401478 ; 81271644 ; 81271546 ; 81271549 ; 81470816 ; 81471737)
WOS Research AreaBiochemistry & Molecular Biology ; Substance Abuse
WOS SubjectBiochemistry & Molecular Biology ; Substance Abuse
WOS IDWOS:000425369000021
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/21962
Collection中国科学院分子影像重点实验室
Affiliation1.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Inner Mongolia Key Lab Pattern Recognit & Intelli, Baotou 014010, Inner Mongolia, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
3.Inner Mongolia Univ Sci & Technol, Baotou Med Coll, Dept Med Imaging, Affiliated Hosp 1, Baotou, Peoples R China
4.Guangxi Normal Univ, Guangxi Key Lab Multisource Informat Min & Secur, Guilin, Peoples R China
5.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Yu, Dahua,Yuan, Kai,Bi, Yanzhi,et al. Altered interhemispheric resting-state functional connectivity in young male smokers[J]. ADDICTION BIOLOGY,2018,23(2):772-780.
APA Yu, Dahua.,Yuan, Kai.,Bi, Yanzhi.,Luo, Lin.,Zhai, Jinquan.,...&Lu, Xiaoqi.(2018).Altered interhemispheric resting-state functional connectivity in young male smokers.ADDICTION BIOLOGY,23(2),772-780.
MLA Yu, Dahua,et al."Altered interhemispheric resting-state functional connectivity in young male smokers".ADDICTION BIOLOGY 23.2(2018):772-780.
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