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Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations
Li, Jin1,2; Zhang, Xiaolong1,2; Li, Ang1,2; Liu, Shu1,2; Qin, Wen3; Yu, Chunshui3; Liu, Yong1,2; Liu, Bing1,2; Jiang, Tianzi1,2,4,5,6
2018-04-01
发表期刊NEUROBIOLOGY OF AGING
卷号64页码:116-122
文章类型Article
摘要Alzheimer's disease (AD) is heritable with complex genetic underpinnings. Based on previous results from large-scale genome-wide association studies, recent studies found an association between the polygenic risk score (PGRS) of AD and the structure of some preselected brain regions, but the effects of AD PGRS on all voxels of the brain have not been fully investigated. In the present study, we examined the voxel-wise effect of AD PGRS on the entire brain and the influence of AD PGRS on cognitive function in 2 independent healthy young cohorts. In both cohorts, an elevated AD PGRS was associated with a smaller precuneal volume, and the effect remained after excluding the APOE genotype. No correlation was found between AD PGRS and any cognitive measure in either sample. Finding a negative correlation between the AD PGRS and the precuneal volume could help to elucidate the mechanism of the genetic risk for AD and could provide a potential biomarker for early detection and possible interventions in AD. (C) 2018 Elsevier Inc. All rights reserved.
关键词Alzheimer's Disease Neuroimaging Polygenic Risk Score Precuneus
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.neurobiolaging.2017.12.022
关键词[WOS]MILD COGNITIVE IMPAIRMENT ; GRAY-MATTER VOLUME ; FUNCTIONAL CONNECTIVITY ; SWEDISH TWINS ; GENETIC RISK ; DEMENTIA ; ATROPHY ; SCORES ; MRI ; INDIVIDUALS
收录类别SCI
语种英语
项目资助者National Key Research and Development Plan(2016YFC0904300) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(31300934 ; Youth Innovation Promotion Association, Chinese Academy of Science ; Open Research Fund of the Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning(CNLYB1509) ; 81771393 ; 31571150)
WOS研究方向Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目Geriatrics & Gerontology ; Neurosciences
WOS记录号WOS:000425755700012
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/21966
专题脑网络组研究中心
作者单位1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin, Peoples R China
4.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Automat, Beijing, Peoples R China
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Sichuan, Peoples R China
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GB/T 7714
Li, Jin,Zhang, Xiaolong,Li, Ang,et al. Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations[J]. NEUROBIOLOGY OF AGING,2018,64:116-122.
APA Li, Jin.,Zhang, Xiaolong.,Li, Ang.,Liu, Shu.,Qin, Wen.,...&Jiang, Tianzi.(2018).Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations.NEUROBIOLOGY OF AGING,64,116-122.
MLA Li, Jin,et al."Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations".NEUROBIOLOGY OF AGING 64(2018):116-122.
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