Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations

doi:10.1016/j.neurobiolaging.2017.12.022

	Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations
	Li, Jin1,2 ; Zhang, Xiaolong 1,2; Li, Ang1,2 ; Liu, Shu1,2 ; Qin, Wen 3; Yu, Chunshui 3; Liu, Yong1,2 ; Liu, Bing1,2 ; Jiang, Tianzi1,2,4,5,6
发表期刊	NEUROBIOLOGY OF AGING
	2018-04-01
卷号	64 页码:116-122
文章类型	Article
摘要	Alzheimer's disease (AD) is heritable with complex genetic underpinnings. Based on previous results from large-scale genome-wide association studies, recent studies found an association between the polygenic risk score (PGRS) of AD and the structure of some preselected brain regions, but the effects of AD PGRS on all voxels of the brain have not been fully investigated. In the present study, we examined the voxel-wise effect of AD PGRS on the entire brain and the influence of AD PGRS on cognitive function in 2 independent healthy young cohorts. In both cohorts, an elevated AD PGRS was associated with a smaller precuneal volume, and the effect remained after excluding the APOE genotype. No correlation was found between AD PGRS and any cognitive measure in either sample. Finding a negative correlation between the AD PGRS and the precuneal volume could help to elucidate the mechanism of the genetic risk for AD and could provide a potential biomarker for early detection and possible interventions in AD. (C) 2018 Elsevier Inc. All rights reserved.
关键词	Alzheimer's Disease Neuroimaging Polygenic Risk Score Precuneus
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1016/j.neurobiolaging.2017.12.022
关键词[WOS]	MILD COGNITIVE IMPAIRMENT ; GRAY-MATTER VOLUME ; FUNCTIONAL CONNECTIVITY ; SWEDISH TWINS ; GENETIC RISK ; DEMENTIA ; ATROPHY ; SCORES ; MRI ; INDIVIDUALS
收录类别	SCI
语种	英语
项目资助者	National Key Research and Development Plan(2016YFC0904300) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(31300934 ; Youth Innovation Promotion Association, Chinese Academy of Science ; Open Research Fund of the Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning(CNLYB1509) ; 81771393 ; 31571150)
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS记录号	WOS:000425755700012
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/21966
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin, Peoples R China 4.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Automat, Beijing, Peoples R China 5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia 6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Sichuan, Peoples R China
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Li, Jin,Zhang, Xiaolong,Li, Ang,et al. Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations[J]. NEUROBIOLOGY OF AGING,2018,64:116-122.
APA	Li, Jin.,Zhang, Xiaolong.,Li, Ang.,Liu, Shu.,Qin, Wen.,...&Jiang, Tianzi.(2018).Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations.NEUROBIOLOGY OF AGING,64,116-122.
MLA	Li, Jin,et al."Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations".NEUROBIOLOGY OF AGING 64(2018):116-122.