CASIA OpenIR  > 脑网络组研究中心
Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations
Li, Jin1,2; Zhang, Xiaolong1,2; Li, Ang1,2; Liu, Shu1,2; Qin, Wen3; Yu, Chunshui3; Liu, Yong1,2; Liu, Bing1,2; Jiang, Tianzi1,2,4,5,6
Source PublicationNEUROBIOLOGY OF AGING
2018-04-01
Volume64Pages:116-122
SubtypeArticle
AbstractAlzheimer's disease (AD) is heritable with complex genetic underpinnings. Based on previous results from large-scale genome-wide association studies, recent studies found an association between the polygenic risk score (PGRS) of AD and the structure of some preselected brain regions, but the effects of AD PGRS on all voxels of the brain have not been fully investigated. In the present study, we examined the voxel-wise effect of AD PGRS on the entire brain and the influence of AD PGRS on cognitive function in 2 independent healthy young cohorts. In both cohorts, an elevated AD PGRS was associated with a smaller precuneal volume, and the effect remained after excluding the APOE genotype. No correlation was found between AD PGRS and any cognitive measure in either sample. Finding a negative correlation between the AD PGRS and the precuneal volume could help to elucidate the mechanism of the genetic risk for AD and could provide a potential biomarker for early detection and possible interventions in AD. (C) 2018 Elsevier Inc. All rights reserved.
KeywordAlzheimer's Disease Neuroimaging Polygenic Risk Score Precuneus
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.neurobiolaging.2017.12.022
WOS KeywordMILD COGNITIVE IMPAIRMENT ; GRAY-MATTER VOLUME ; FUNCTIONAL CONNECTIVITY ; SWEDISH TWINS ; GENETIC RISK ; DEMENTIA ; ATROPHY ; SCORES ; MRI ; INDIVIDUALS
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Plan(2016YFC0904300) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(31300934 ; Youth Innovation Promotion Association, Chinese Academy of Science ; Open Research Fund of the Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning(CNLYB1509) ; 81771393 ; 31571150)
WOS Research AreaGeriatrics & Gerontology ; Neurosciences & Neurology
WOS SubjectGeriatrics & Gerontology ; Neurosciences
WOS IDWOS:000425755700012
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/21966
Collection脑网络组研究中心
Affiliation1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin, Peoples R China
4.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Automat, Beijing, Peoples R China
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Sichuan, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Li, Jin,Zhang, Xiaolong,Li, Ang,et al. Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations[J]. NEUROBIOLOGY OF AGING,2018,64:116-122.
APA Li, Jin.,Zhang, Xiaolong.,Li, Ang.,Liu, Shu.,Qin, Wen.,...&Jiang, Tianzi.(2018).Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations.NEUROBIOLOGY OF AGING,64,116-122.
MLA Li, Jin,et al."Polygenic risk for Alzheimer's disease influences precuneal volume in two independent general populations".NEUROBIOLOGY OF AGING 64(2018):116-122.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Jin]'s Articles
[Zhang, Xiaolong]'s Articles
[Li, Ang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Jin]'s Articles
[Zhang, Xiaolong]'s Articles
[Li, Ang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Jin]'s Articles
[Zhang, Xiaolong]'s Articles
[Li, Ang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.