Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults

doi:10.3389/fnins.2018.00233

	Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults
	Xu, Qiang 1; Fu, Jilian 1; Liu, Feng 1; Qin, Wen 1; Liu, Bing2 ; Jiang, Tianzi2 ; Yu, Chunshui 1
发表期刊	FRONTIERS IN NEUROSCIENCE
	2018-04-10
卷号	12
文章类型	Article
摘要	In Chinese Han population, Catechol-O-methyltransferase gene (COMT) rs4633 is found to be associated with impaired cognitive process. We aimed to investigate the association between COMT rs4633 and verbal intelligence and the underlying neural mechanisms in Chinese Han healthy young adults. In 256 Chinese Han healthy young adults, we explored the modulatory effects of COMT rs4633 on verbal intelligence quotient (VIQ) and functional connectivity density (FCD) of the brain and the mediation effect of FCD on the association between COMT and VIQ. We further investigated the association between the expression patterns of dopamine receptor genes and the effect of COMT on FCD in the human brain. COMT rs4633 TT homozygotes exhibited lower VIQ than CC homozygotes and TC heterozygotes, higher long-range FCD (IrFCD) than CC homozygotes and TO heterozygotes in the left superior frontal gyrus. TT homozygotes and TC heterozygotes showed higher IrFCD than CC homozygotes in the left inferior parietal lobule. The IrFCD differences across genotypic subgroups were negatively associated with the expression of DRD2 and DRD3 genes. The left parietal IrFCD mediated the association between COMT rs4633 and VIQ. These findings provide a biological pathway that COMT rs4633 affects verbal intelligence via modulating the IrFCD of the left inferior parietal lobule.
关键词	Comt Functional Connectivity Density Functional Magnetic Resonance Imaging Single Nucleotide Polymorphism Verbal Intelligence
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.3389/fnins.2018.00233
关键词[WOS]	CATECHOL-O-METHYLTRANSFERASE ; HUMAN BRAIN ; WORKING-MEMORY ; DOPAMINE ; SCHIZOPHRENIA ; DENSITY ; EXPRESSION ; RECEPTORS ; NETWORKS ; PLASMA
收录类别	SCI
语种	英语
项目资助者	Natural Science Foundation of China(81425013 ; 81501451 ; 81401394)
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000429597100001
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/22010
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin Key Lab Funct Imaging, Tianjin, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Xu, Qiang,Fu, Jilian,Liu, Feng,et al. Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults[J]. FRONTIERS IN NEUROSCIENCE,2018,12.
APA	Xu, Qiang.,Fu, Jilian.,Liu, Feng.,Qin, Wen.,Liu, Bing.,...&Yu, Chunshui.(2018).Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults.FRONTIERS IN NEUROSCIENCE,12.
MLA	Xu, Qiang,et al."Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults".FRONTIERS IN NEUROSCIENCE 12(2018).