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Y-1 receptor ligand-based nanomicelle as a novel nanoprobe for glioma-targeted imaging and therapy
Li, Juan1,2; Du, Yang3; Jiang, Zhenqi1,2,4; Tian, Yuchen1,2; Qiu, Nianxiang1,2; Wang, Yinjie1,2,4; Lqbal, Muhammad Zubair1,2; Hu, Menying1,2; Zou, Ruifen1,2,4; Luo, Lijia1,2,4; Du, Shiyu1,2; Tian, Jie3; Wu, Aiguo1,2
2018-04-07
发表期刊NANOSCALE
卷号10期号:13页码:5845-5851
文章类型Article
摘要Due to the molecular and cellular heterogeneity of glioma, discovery of novel targeted sites and ligands for glioma imaging and therapy remains challenging. Neuropeptide Y (NPY) Y-1 receptors (Y(1)Rs) are highly over expressed in various brain tumors including glioma, and can serve as potential targeting sites for glioma imaging and therapy. Here, we show by in vivo fluorescent imaging that a highly selective Y1R ligand, [Asn(6), Pro(34)] NPY (AP-NPY), facilitated circumvention of the blood brain barrier (BBB) by nanomicelles specifically targeting glioma. Modification with AP-NPY stabilized doxorubicin-loaded nanomicelles in the normal physiological state and promoted drug release in the acidic tumor microenvironment. Furthermore, targeted delivery of AP-NPY nanomicelles improved the therapeutic efficacy of doxorubicin for glioma, producing a prolonged survival rate. These results suggest that Y1R is a novel targeted receptor, and its selective ligand AP-NPY improves BBB permeability and glioma targeting. Our study paves the way for developing a novel delivery system for diagnosis and treatment of glioma in which Y(1)Rs are over expressed.
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1039/c8nr00148k
关键词[WOS]BLOOD-BRAIN-BARRIER ; NEUROPEPTIDE-Y RECEPTORS ; BREAST-CANCER ; TUMOR HETEROGENEITY ; DRUG-DELIVERY ; HIGH-GRADE ; NANOPARTICLES ; INTERNALIZATION ; Y-1-RECEPTOR ; PERMEABILITY
收录类别SCI
语种英语
项目资助者Natural Science Foundation of China(51303196 ; Science and Technology Department of Zhejiang Province(2016C33093 ; Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund (the second phase)(U1501501) ; Youth Innovation Promotion Association Foundation, CAS(2017340) ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; International Innovation Team of CAS(20140491524) ; Bureau of Science and Technology of Ningbo Municipality City(2015C50004 ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; U1432114 ; 2017C33129 ; 2015B11002 ; 81227901 ; 2017C03042 ; 2017C110022) ; 81527805 ; LY18H180011) ; 61231004 ; 81470083)
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000428788200007
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/22020
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo 315201, Zhejiang, Peoples R China
2.Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Div Funct Mat & Nanodevices, Ningbo 315201, Zhejiang, Peoples R China
3.Chinese Acad Sci, Inst Automat, Sate Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Li, Juan,Du, Yang,Jiang, Zhenqi,et al. Y-1 receptor ligand-based nanomicelle as a novel nanoprobe for glioma-targeted imaging and therapy[J]. NANOSCALE,2018,10(13):5845-5851.
APA Li, Juan.,Du, Yang.,Jiang, Zhenqi.,Tian, Yuchen.,Qiu, Nianxiang.,...&Wu, Aiguo.(2018).Y-1 receptor ligand-based nanomicelle as a novel nanoprobe for glioma-targeted imaging and therapy.NANOSCALE,10(13),5845-5851.
MLA Li, Juan,et al."Y-1 receptor ligand-based nanomicelle as a novel nanoprobe for glioma-targeted imaging and therapy".NANOSCALE 10.13(2018):5845-5851.
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