CASIA OpenIR  > 中国科学院分子影像重点实验室
Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy
Xiaodong Song1,2,3,4; Wenting Shang2,3; Li Peng2,3; Hongmei Jiang2,3; Kun Wang2,3; Chihua Fang1,4; Jie Tian2,3
Source PublicationNANOMEDICINE
ISSN1743-5889
2018-07-01
Volume13Issue:14Pages:1681-1693
Corresponding AuthorWang, Kun(kun.wang@ia.ac.cn) ; Fang, Chihua(fangch_dr@126.com) ; Tian, Jie(jie.tian@ia.ac.cn)
AbstractAim: The diagnosis and treatment of hepatocarcinoma (HCC) is believed to be improved due to the development of specific targeting probes by molecular imaging methods. GPC3, which is a hepatocellular carcinoma (HCC)-specific tumor marker, anchors at most HCC cells. To target this cell membrane protein, we developed a novel nanoparticle by conjugating WS2-Ga3+-PEG and a short peptide with favorable specificity and affinity to the GPC3 protein. Materials & methods: In in vitro assay, several physical properties of the novel probe were evaluated. In in vivo assay, MRI, photoacoustic imaging and photothermal therapy were performed in the subcutaneous HepG2-bearing mice with the novel probe. Results & conclusion: The effect of imaging and photothermal therapy was significant. We revealed that the novel nanosheet WS2-Ga3+-PEG-peptide is promising to detect and treat HCC-expressing GPC3.
Keywordhepatocellular carcinoma imaging-guided photothermal therapy
DOI10.2217/nnm-2017-0367
WOS KeywordEARLY HEPATOCELLULAR-CARCINOMA ; ALPHA-FETOPROTEIN ; MOS2 NANOSHEETS ; CANCER-THERAPY ; LIVER-LESIONS ; GLYPICAN-3 ; MRI ; DIFFERENTIATION ; METAANALYSIS ; TOMOGRAPHY
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81627805] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[81501540] ; National Natural Science Foundation of China[81527805] ; Science and Technology Plan Project of Guangzhou[201604020144] ; Digital Theranostic Equipment Research Special Program of The 13th five-year' National Key Research Plan[2016YFC0106500] ; United Fund of National Natural Science Foundation of China ; Government of Guangdong Province[U1401254]
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China ; Science and Technology Plan Project of Guangzhou ; Digital Theranostic Equipment Research Special Program of The 13th five-year' National Key Research Plan ; United Fund of National Natural Science Foundation of China ; Government of Guangdong Province
WOS Research AreaBiotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS SubjectBiotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS IDWOS:000446356400002
PublisherFUTURE MEDICINE LTD
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/22027
Collection中国科学院分子影像重点实验室
Affiliation1.Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, PR China
2.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, PR China
3.Beijing Key Laboratory of Molecular Imaging, Beijing 100190, PR China
4.Guangdong Provincial Clinical & Engineering Center of Digital Medicine, Guangzhou, PR China
Recommended Citation
GB/T 7714
Xiaodong Song,Wenting Shang,Li Peng,et al. Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy[J]. NANOMEDICINE,2018,13(14):1681-1693.
APA Xiaodong Song.,Wenting Shang.,Li Peng.,Hongmei Jiang.,Kun Wang.,...&Jie Tian.(2018).Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy.NANOMEDICINE,13(14),1681-1693.
MLA Xiaodong Song,et al."Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy".NANOMEDICINE 13.14(2018):1681-1693.
Files in This Item: Download All
File Name/Size DocType Version Access License
10.Xiaodong Song.pdf(5181KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xiaodong Song]'s Articles
[Wenting Shang]'s Articles
[Li Peng]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xiaodong Song]'s Articles
[Wenting Shang]'s Articles
[Li Peng]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xiaodong Song]'s Articles
[Wenting Shang]'s Articles
[Li Peng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 10.Xiaodong Song.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.