Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy

doi:10.2217/nnm-2017-0367

	Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy
	Xiaodong Song 1,2,3,4; Wenting Shang2,3 ; Li Peng 2,3; Hongmei Jiang 2,3; Kun Wang2,3 ; Chihua Fang 1,4; Jie Tian 2,3
发表期刊	NANOMEDICINE
ISSN	1743-5889
	2018-07-01
卷号	13 期号:14 页码:1681-1693
通讯作者	Wang, Kun(kun.wang@ia.ac.cn) ; Fang, Chihua(fangch_dr@126.com) ; Tian, Jie(jie.tian@ia.ac.cn)
摘要	Aim: The diagnosis and treatment of hepatocarcinoma (HCC) is believed to be improved due to the development of specific targeting probes by molecular imaging methods. GPC3, which is a hepatocellular carcinoma (HCC)-specific tumor marker, anchors at most HCC cells. To target this cell membrane protein, we developed a novel nanoparticle by conjugating WS2-Ga3+-PEG and a short peptide with favorable specificity and affinity to the GPC3 protein. Materials & methods: In in vitro assay, several physical properties of the novel probe were evaluated. In in vivo assay, MRI, photoacoustic imaging and photothermal therapy were performed in the subcutaneous HepG2-bearing mice with the novel probe. Results & conclusion: The effect of imaging and photothermal therapy was significant. We revealed that the novel nanosheet WS2-Ga3+-PEG-peptide is promising to detect and treat HCC-expressing GPC3.
关键词	hepatocellular carcinoma imaging-guided photothermal therapy
DOI	10.2217/nnm-2017-0367
关键词[WOS]	EARLY HEPATOCELLULAR-CARCINOMA ; ALPHA-FETOPROTEIN ; MOS2 NANOSHEETS ; CANCER-THERAPY ; LIVER-LESIONS ; GLYPICAN-3 ; MRI ; DIFFERENTIATION ; METAANALYSIS ; TOMOGRAPHY
收录类别	SCI
语种	英语
资助项目	Government of Guangdong Province[U1401254] ; United Fund of National Natural Science Foundation of China ; Digital Theranostic Equipment Research Special Program of The 13th five-year' National Key Research Plan[2016YFC0106500] ; Science and Technology Plan Project of Guangzhou[201604020144] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81501540] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81627805] ; National Natural Science Foundation of China[81227901] ; National Key R&D Program of China[2017YFA0205200] ; National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81627805] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[81501540] ; National Natural Science Foundation of China[81527805] ; Science and Technology Plan Project of Guangzhou[201604020144] ; Digital Theranostic Equipment Research Special Program of The 13th five-year' National Key Research Plan[2016YFC0106500] ; United Fund of National Natural Science Foundation of China ; Government of Guangdong Province[U1401254]
项目资助者	National Key R&D Program of China ; National Natural Science Foundation of China ; Science and Technology Plan Project of Guangzhou ; Digital Theranostic Equipment Research Special Program of The 13th five-year' National Key Research Plan ; United Fund of National Natural Science Foundation of China ; Government of Guangdong Province
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS类目	Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS记录号	WOS:000446356400002
出版者	FUTURE MEDICINE LTD
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/22027
专题	中国科学院分子影像重点实验室
作者单位	1.Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, PR China 2.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, PR China 3.Beijing Key Laboratory of Molecular Imaging, Beijing 100190, PR China 4.Guangdong Provincial Clinical & Engineering Center of Digital Medicine, Guangzhou, PR China
第一作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Xiaodong Song,Wenting Shang,Li Peng,et al. Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy[J]. NANOMEDICINE,2018,13(14):1681-1693.
APA	Xiaodong Song.,Wenting Shang.,Li Peng.,Hongmei Jiang.,Kun Wang.,...&Jie Tian.(2018).Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy.NANOMEDICINE,13(14),1681-1693.
MLA	Xiaodong Song,et al."Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy".NANOMEDICINE 13.14(2018):1681-1693.

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