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Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy
Xiaodong Song1,2,3,4; Wenting Shang2,3; Li Peng2,3; Hongmei Jiang2,3; Kun Wang2,3; Chihua Fang1,4; Jie Tian2,3
2018-08
发表期刊Nanomedicine (Lond.)
期号x页码:x
摘要Aim: The diagnosis and treatment of hepatocarcinoma (HCC) is believed to be improved due to the development of specifc targeting probes by molecular imaging methods. GPC3, which is a hepatocellular carcinoma (HCC)-specifc tumor marker, anchors at most HCC cells. To target this cell membrane protein, we developed a novel nanoparticle by conjugating WS2-Ga3+-PEG and a short peptide with favorable specifcity and affnity to the GPC3 protein. Materials & methods: In in vitro assay, several physical properties of the novel probe were evaluated. In in vivo assay, MRI, photoacoustic imaging and photothermal therapy were performed in the subcutaneous HepG2-bearing mice with the novel probe. Results & conclusion: The effect of imaging and photothermal therapy was signifcant. We revealed that the novel nanosheet WS2-Ga3+-PEG-peptide is promising to detect and treat HCC-expressing GPC3.
关键词Gpc3 Hepatocellular Carcinoma Nanosheets
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/22027
专题中国科学院分子影像重点实验室
作者单位1.Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, PR China
2.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, PR China
3.Beijing Key Laboratory of Molecular Imaging, Beijing 100190, PR China
4.Guangdong Provincial Clinical & Engineering Center of Digital Medicine, Guangzhou, PR China
推荐引用方式
GB/T 7714
Xiaodong Song,Wenting Shang,Li Peng,et al. Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy[J]. Nanomedicine (Lond.),2018(x):x.
APA Xiaodong Song.,Wenting Shang.,Li Peng.,Hongmei Jiang.,Kun Wang.,...&Jie Tian.(2018).Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy.Nanomedicine (Lond.)(x),x.
MLA Xiaodong Song,et al."Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy".Nanomedicine (Lond.) .x(2018):x.
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