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Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy
Xiaodong Song1,2,3,4; Wenting Shang2,3; Li Peng2,3; Hongmei Jiang2,3; Kun Wang2,3; Chihua Fang1,4; Jie Tian2,3
发表期刊NANOMEDICINE
ISSN1743-5889
2018-07-01
卷号13期号:14页码:1681-1693
通讯作者Wang, Kun(kun.wang@ia.ac.cn) ; Fang, Chihua(fangch_dr@126.com) ; Tian, Jie(jie.tian@ia.ac.cn)
摘要Aim: The diagnosis and treatment of hepatocarcinoma (HCC) is believed to be improved due to the development of specific targeting probes by molecular imaging methods. GPC3, which is a hepatocellular carcinoma (HCC)-specific tumor marker, anchors at most HCC cells. To target this cell membrane protein, we developed a novel nanoparticle by conjugating WS2-Ga3+-PEG and a short peptide with favorable specificity and affinity to the GPC3 protein. Materials & methods: In in vitro assay, several physical properties of the novel probe were evaluated. In in vivo assay, MRI, photoacoustic imaging and photothermal therapy were performed in the subcutaneous HepG2-bearing mice with the novel probe. Results & conclusion: The effect of imaging and photothermal therapy was significant. We revealed that the novel nanosheet WS2-Ga3+-PEG-peptide is promising to detect and treat HCC-expressing GPC3.
关键词hepatocellular carcinoma imaging-guided photothermal therapy
DOI10.2217/nnm-2017-0367
关键词[WOS]EARLY HEPATOCELLULAR-CARCINOMA ; ALPHA-FETOPROTEIN ; MOS2 NANOSHEETS ; CANCER-THERAPY ; LIVER-LESIONS ; GLYPICAN-3 ; MRI ; DIFFERENTIATION ; METAANALYSIS ; TOMOGRAPHY
收录类别SCI
语种英语
资助项目National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81627805] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[81501540] ; National Natural Science Foundation of China[81527805] ; Science and Technology Plan Project of Guangzhou[201604020144] ; Digital Theranostic Equipment Research Special Program of The 13th five-year' National Key Research Plan[2016YFC0106500] ; United Fund of National Natural Science Foundation of China ; Government of Guangdong Province[U1401254]
项目资助者National Key R&D Program of China ; National Natural Science Foundation of China ; Science and Technology Plan Project of Guangzhou ; Digital Theranostic Equipment Research Special Program of The 13th five-year' National Key Research Plan ; United Fund of National Natural Science Foundation of China ; Government of Guangdong Province
WOS研究方向Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS类目Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS记录号WOS:000446356400002
出版者FUTURE MEDICINE LTD
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/22027
专题中国科学院分子影像重点实验室
作者单位1.Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, PR China
2.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, PR China
3.Beijing Key Laboratory of Molecular Imaging, Beijing 100190, PR China
4.Guangdong Provincial Clinical & Engineering Center of Digital Medicine, Guangzhou, PR China
推荐引用方式
GB/T 7714
Xiaodong Song,Wenting Shang,Li Peng,et al. Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy[J]. NANOMEDICINE,2018,13(14):1681-1693.
APA Xiaodong Song.,Wenting Shang.,Li Peng.,Hongmei Jiang.,Kun Wang.,...&Jie Tian.(2018).Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy.NANOMEDICINE,13(14),1681-1693.
MLA Xiaodong Song,et al."Novel GPC3-binding WS2-Ga3+-PEG-peptide nanosheets for in vivo bimodal imaging-guided photothermal therapy".NANOMEDICINE 13.14(2018):1681-1693.
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