CASIA OpenIR  > 中国科学院分子影像重点实验室
Advanced nanomaterials targeting hypoxia to enhance radiotherapy
Jia Li; Wenting Shang; Yong Li; Sirui Fu; Jie Tian; Ligong Lu
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN1178-2013
2018
Volume13Pages:5925-5936
Corresponding AuthorTian, Jie(jie.tian@ia.ac.cn) ; Lu, Ligong(luligong1969@126.com)
AbstractHypoxia within solid tumors is often responsible for the failure of radiotherapy. The development of hypoxia-targeting nanomaterials - aimed at enhancing the effect of radiotherapy by electrical or heat effects and at modulating hypoxia in the tumor microenvironment - is a promising strategy to address this issue. We provide an overview of recently developed advanced materials that potentiate radiotherapy. First, we summarize novel materials for oxygen delivery or production to modify the tumor microenvironment, thus improving the effects of ionizing radiation. Second, we present new approaches for the design of high-Z element-based multifunctional nanoplatforms to enhance radiotherapy. Third, novel drug delivery systems for hypoxic regions and hypoxia-inducible factor-1-targeted therapies are discussed. Fourth, we establish the effectiveness of X-ray-or near-infrared-responsive nanoparticles for selectively triggering therapeutic effects under hypoxic conditions. Finally, this review emphasizes the importance of research in the field of nanomedicine focused on tumor hypoxia to improve clinical outcomes.
Keywordradiotherapy hypoxia nanomaterials hypoxia inducible factor 1
DOI10.2147/IJN.S173914
WOS KeywordOVERCOME TUMOR HYPOXIA ; DRUG-DELIVERY SYSTEMS ; BREAST-CANCER CELLS ; GOLD NANOPARTICLES ; OXYGEN DELIVERY ; CLINICAL-APPLICATIONS ; RECTAL-CANCER ; IN-VIVO ; MULTIFUNCTIONAL NANOTHERANOSTICS ; POSTOPERATIVE CHEMORADIOTHERAPY
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2017YFA0205 200] ; National Natural Science Foundation of China[81571785] ; National Natural Science Foundation of China[81771957] ; National Natural Science Foundation of China[81502642] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[81501540] ; Natural Science Foundation of Guangdong Province, China[2016A030311055] ; Natural Science Foundation of Guangdong Province, China[2016A030313770] ; Natural Science Foundation of Guangdong Province, China[2015A030310108] ; Chinese Academy of Sciences[GJJSTD20170004] ; State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences[20180111]
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province, China ; Chinese Academy of Sciences ; State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences
WOS Research AreaScience & Technology - Other Topics ; Pharmacology & Pharmacy
WOS SubjectNanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS IDWOS:000446664200001
PublisherDOVE MEDICAL PRESS LTD
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/22028
Collection中国科学院分子影像重点实验室
Affiliation1.Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Jinan University, Zhuhai, China
2.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China
3.Beijing Key Laboratory of Molecular Imaging, Beijing, China
Recommended Citation
GB/T 7714
Jia Li,Wenting Shang,Yong Li,et al. Advanced nanomaterials targeting hypoxia to enhance radiotherapy[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2018,13:5925-5936.
APA Jia Li,Wenting Shang,Yong Li,Sirui Fu,Jie Tian,&Ligong Lu.(2018).Advanced nanomaterials targeting hypoxia to enhance radiotherapy.INTERNATIONAL JOURNAL OF NANOMEDICINE,13,5925-5936.
MLA Jia Li,et al."Advanced nanomaterials targeting hypoxia to enhance radiotherapy".INTERNATIONAL JOURNAL OF NANOMEDICINE 13(2018):5925-5936.
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