Blood pressure-lowering drugs and secondary prevention of cardiovascular disease: systematic review and meta-analysis | |
Xie, Wuxiang1,2; Zheng, Fanfan3,4; Evangelou, Evangelos2; Liu, Ou5; Yang, Zhenchun2; Chan, Queenie2; Elliott, Paul2; Wu, Yangfeng1 | |
发表期刊 | JOURNAL OF HYPERTENSION |
2018-06-01 | |
卷号 | 36期号:6页码:1256-1265 |
文章类型 | Review |
摘要 | Objective:To systematically evaluate the efficacy of five commonly used blood pressure-lowering drugs in reducing cardiovascular events among patients with nonacute cardiovascular disease, but without heart failure.Methods:We searched PubMed, EMBASE, and Cochrane Central Register of Controlled Trials on 18 March 2017. The primary outcome was fatal and nonfatal cardiovascular events, and the secondary outcomes were all-cause death, fatal and nonfatal myocardial infarction, and stroke. Pooled risk ratios and corresponding 95% confidence intervals (CIs) were calculated using Mantel-Haenszel random-effects meta-analyses.Results:Twenty-seven randomized controlled trials with 143095 participants and a treatment duration of at least 12 months were included in our analyses. Fifteen trials enrolled patients with coronary artery disease, eight enrolled patients with cerebral artery disease, and four enrolled patients with cardiovascular disease. Of the 27 trials, 10 trials only included hypertensive patients. Compared with placebo, angiotensin-converting enzyme inhibitors (ACEIs) (risk ratio 0.85, 95% CI 0.78-0.92), angiotensin receptor blockers (risk ratio 0.92, 95% CI 0.87-0.98), and diuretics (risk ratio 0.77, 95% CI 0.66-0.90) significantly reduced the risk of cardiovascular events. Apart from this, ACEIs significantly reduced all secondary outcomes, calcium channel blockers, and diuretics reduced stroke significantly. No significant difference was found in head-to-head comparisons of each given drug class with any other class.Conclusions:Although only ACEIs have evidences showing its effect in reducing cardiovascular events and all secondary outcomes, head-to-head comparisons did not provide strong evidence in difference in the effects between these blood pressure-lowering drugs. |
关键词 | Blood Pressure-lowering Cardiovascular Disease Meta-analysis Secondary Prevention |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1097/HJH.0000000000001720 |
关键词[WOS] | CORONARY-ARTERY-DISEASE ; RANDOMIZED CONTROLLED-TRIAL ; CONVERTING-ENZYME-INHIBITION ; TRANSIENT ISCHEMIC ATTACK ; HIGH-RISK PATIENTS ; ATHEROSCLEROTIC VASCULAR-DISEASE ; ACUTE MYOCARDIAL-INFARCTION ; AMERICAN-HEART-ASSOCIATION ; PLACEBO-CONTROLLED TRIAL ; OUTCOME INCIDENCE |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | Newton International Fellowship from the Academy of Medical Sciences(P56804) |
WOS研究方向 | Cardiovascular System & Cardiology |
WOS类目 | Peripheral Vascular Disease |
WOS记录号 | WOS:000431515500005 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/22035 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
作者单位 | 1.Peking Univ, Clin Res Inst, Beijing, Peoples R China 2.Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 4.UCL, Inst Cognit Neurosci, London, England 5.Capital Med Univ, Beijing Lab Cardiovasc Precis Med, Anzhen Hosp, Dept Cardiovasc Surg, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Xie, Wuxiang,Zheng, Fanfan,Evangelou, Evangelos,et al. Blood pressure-lowering drugs and secondary prevention of cardiovascular disease: systematic review and meta-analysis[J]. JOURNAL OF HYPERTENSION,2018,36(6):1256-1265. |
APA | Xie, Wuxiang.,Zheng, Fanfan.,Evangelou, Evangelos.,Liu, Ou.,Yang, Zhenchun.,...&Wu, Yangfeng.(2018).Blood pressure-lowering drugs and secondary prevention of cardiovascular disease: systematic review and meta-analysis.JOURNAL OF HYPERTENSION,36(6),1256-1265. |
MLA | Xie, Wuxiang,et al."Blood pressure-lowering drugs and secondary prevention of cardiovascular disease: systematic review and meta-analysis".JOURNAL OF HYPERTENSION 36.6(2018):1256-1265. |
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