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Radionuclide Imaging-Guided Chemo-Radioisotope Synergistic Therapy Using a I-131-Labeled Polydopamine Multifunctional Nanocarrier
Li, Zhiqiang1,2,3; Wang, Baikui2,3; Zhang, Zheng2,3; Wang, Bo1; Xu, Qiangqiang1; Mao, Wenjie1; Tian, Jie1,4; Yang, Kai2,3; Wang, Fu1
2018-05-02
发表期刊MOLECULAR THERAPY
卷号26期号:5页码:1385-1393
文章类型Article
摘要Development of biocompatible nanomaterials with multiple functionalities for combination of radiotherapy and chemotherapy has attracted tremendous attention in cancer treatment. Herein, poly(ethylene glycol) (PEG) modified polydopamine (PDA) nanoparticles were successfully developed as a favorable biocompatible nanoplatform for co-loading antitumor drugs and radionuclides to achieve imaging-guided combined radio-chemotherapy. It is demonstrated that PEGylated PDA nanoparticles can effectively load two different drugs including sanguinarine (SAN) and metformin (MET), as well as radionuclides I-131 in one system. The loaded SAN and MET could inhibit tumor growth via inducing cell apoptosis and relieving tumor hypoxia, while labeling PDA-PEG with I-131 enables in vivo radionuclide imaging and radioisotope therapy. As revealed by the therapeutic efficacy both in cell and animal levels, the multifunctional PDA nanoparticles (I-131-PDA-PEG-SAN-MET) can effectively repress the growth of cancer cells in a synergistic manner without significant toxic side effects, exhibiting superior treatment outcome than the respective monotherapy. Therefore, this study provides a promising polymer-based platform to realize imaging-guided radioisotope/chemotherapy combination cancer treatment in future clinical application.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.ymthe.2018.02.019
关键词[WOS]CANCER ; NANOPARTICLES ; VERSATILE ; PLATFORM ; CHEMOTHERAPY ; RESISTANCE
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81571721 ; Natural Science Basis Research Plan in Shaanxi Province of China(2016JM8016) ; 81772010 ; 81227901 ; 81471716)
WOS研究方向Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine
WOS类目Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental
WOS记录号WOS:000431485300022
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/22039
专题中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian 710071, Shaanxi, Peoples R China
2.Soochow Univ, State Key Lab Radiat Med & Protect, Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215123, Jiangsu, Peoples R China
3.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215123, Jiangsu, Peoples R China
4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
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Li, Zhiqiang,Wang, Baikui,Zhang, Zheng,et al. Radionuclide Imaging-Guided Chemo-Radioisotope Synergistic Therapy Using a I-131-Labeled Polydopamine Multifunctional Nanocarrier[J]. MOLECULAR THERAPY,2018,26(5):1385-1393.
APA Li, Zhiqiang.,Wang, Baikui.,Zhang, Zheng.,Wang, Bo.,Xu, Qiangqiang.,...&Wang, Fu.(2018).Radionuclide Imaging-Guided Chemo-Radioisotope Synergistic Therapy Using a I-131-Labeled Polydopamine Multifunctional Nanocarrier.MOLECULAR THERAPY,26(5),1385-1393.
MLA Li, Zhiqiang,et al."Radionuclide Imaging-Guided Chemo-Radioisotope Synergistic Therapy Using a I-131-Labeled Polydopamine Multifunctional Nanocarrier".MOLECULAR THERAPY 26.5(2018):1385-1393.
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