Radionuclide Imaging-Guided Chemo-Radioisotope Synergistic Therapy Using a I-131-Labeled Polydopamine Multifunctional Nanocarrier

doi:10.1016/j.ymthe.2018.02.019

	Radionuclide Imaging-Guided Chemo-Radioisotope Synergistic Therapy Using a I-131-Labeled Polydopamine Multifunctional Nanocarrier
	Li, Zhiqiang 1,2,3; Wang, Baikui 2,3; Zhang, Zheng2,3 ; Wang, Bo 1; Xu, Qiangqiang 1; Mao, Wenjie 1; Tian, Jie 1,4; Yang, Kai 2,3; Wang, Fu 1
发表期刊	MOLECULAR THERAPY
	2018-05-02
卷号	26 期号:5 页码:1385-1393
文章类型	Article
摘要	Development of biocompatible nanomaterials with multiple functionalities for combination of radiotherapy and chemotherapy has attracted tremendous attention in cancer treatment. Herein, poly(ethylene glycol) (PEG) modified polydopamine (PDA) nanoparticles were successfully developed as a favorable biocompatible nanoplatform for co-loading antitumor drugs and radionuclides to achieve imaging-guided combined radio-chemotherapy. It is demonstrated that PEGylated PDA nanoparticles can effectively load two different drugs including sanguinarine (SAN) and metformin (MET), as well as radionuclides I-131 in one system. The loaded SAN and MET could inhibit tumor growth via inducing cell apoptosis and relieving tumor hypoxia, while labeling PDA-PEG with I-131 enables in vivo radionuclide imaging and radioisotope therapy. As revealed by the therapeutic efficacy both in cell and animal levels, the multifunctional PDA nanoparticles (I-131-PDA-PEG-SAN-MET) can effectively repress the growth of cancer cells in a synergistic manner without significant toxic side effects, exhibiting superior treatment outcome than the respective monotherapy. Therefore, this study provides a promising polymer-based platform to realize imaging-guided radioisotope/chemotherapy combination cancer treatment in future clinical application.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1016/j.ymthe.2018.02.019
关键词[WOS]	CANCER ; NANOPARTICLES ; VERSATILE ; PLATFORM ; CHEMOTHERAPY ; RESISTANCE
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(81571721 ; Natural Science Basis Research Plan in Shaanxi Province of China(2016JM8016) ; 81772010 ; 81227901 ; 81471716)
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental
WOS记录号	WOS:000431485300022
引用统计	被引频次：39[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/22039
专题	中国科学院分子影像重点实验室
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian 710071, Shaanxi, Peoples R China 2.Soochow Univ, State Key Lab Radiat Med & Protect, Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215123, Jiangsu, Peoples R China 3.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215123, Jiangsu, Peoples R China 4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Li, Zhiqiang,Wang, Baikui,Zhang, Zheng,et al. Radionuclide Imaging-Guided Chemo-Radioisotope Synergistic Therapy Using a I-131-Labeled Polydopamine Multifunctional Nanocarrier[J]. MOLECULAR THERAPY,2018,26(5):1385-1393.
APA	Li, Zhiqiang.,Wang, Baikui.,Zhang, Zheng.,Wang, Bo.,Xu, Qiangqiang.,...&Wang, Fu.(2018).Radionuclide Imaging-Guided Chemo-Radioisotope Synergistic Therapy Using a I-131-Labeled Polydopamine Multifunctional Nanocarrier.MOLECULAR THERAPY,26(5),1385-1393.
MLA	Li, Zhiqiang,et al."Radionuclide Imaging-Guided Chemo-Radioisotope Synergistic Therapy Using a I-131-Labeled Polydopamine Multifunctional Nanocarrier".MOLECULAR THERAPY 26.5(2018):1385-1393.